糸状仮足、フィロ・ディア
- 関
- filopodial、filopodium、lamellipodia、lobopodia、pseudopodia、pseudopodium
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出典(authority):フリー百科事典『ウィキペディア(Wikipedia)』「2016/03/01 06:11:12」(JST)
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This electron micrograph shows exaggerated filopodia with club-like shape induced by formin mDia2 in cultured cells. These filopodia are filled with bundled actin filaments which were born in and converged from the lamellipodial network.
Filopodia (also microspikes) are slender cytoplasmic projections that extend beyond the leading edge of lamellipodia in migrating cells.[1] They contain actin filaments cross-linked into bundles by actin-binding proteins, e.g. fascin and fimbrin.[2] Filopodia form focal adhesions with the substratum, linking it to the cell surface.[3] Many types of migrating cells display filopodia, which are thought to be involved in both sensation of chemotropic cues, and resulting changes in directed locomotion.
Activation of the Rho family of small Ras-related GTPases, particularly cdc42 and their downstream intermediates results in the polymerization of actin fibers by Ena/Vasp homology proteins.[4] Growth factors bind to receptor tyrosine kinases resulting in the polymerization of actin filaments, which, when cross-linked, make up the supporting cytoskeletal elements of filopodia. Rho activity also results in activation by phosphorylation of ezrin-moesin-radixin family proteins that link actin filaments to the filopodia membrane.[4]
Filopodia have roles in sensing, migration and cell-cell interaction.[1] To close a wound in vertebrates, growth factors stimulate the formation of filopodia in fibroblasts to direct fibroblast migration and wound closure.[5] In developing neurons, filopodia extend from the growth cone at the leading edge. In neurons deprived of filopodia by partial inhibition of actin filaments polymerization, growth cone extension continues as normal but direction of growth is disrupted and highly irregular.[5] Filopodia-like projections have also been linked to dendrite creation when new synapses are formed in the brain.[6][7] In macrophages, filopodia act as phagocytic tentacles and pull bound objects towards the cell for phagocytosis.[8]
Filopodia are also used for movement of bacteria between cells, so as to evade the host immune system. The intracellular bacteria Ehrlichia are transported between cells through the host cell filopodia induced by the pathogen during initial stages of infection.[9] Viruses were shown to be transported along filopodia toward the cell body, leading to cell infection.[10] Directed transport of receptor-bound epidermal growth factor (EGF) along filopodia has also been described, supporting the proposed sensing function of filopodia.[11]
References
- ^ a b Mattila PK, Lappalainen P (June 2008). "Filopodia: molecular architecture and cellular functions". Nat. Rev. Mol. Cell Biol. 9 (6): 446–54. doi:10.1038/nrm2406. PMID 18464790.
- ^ Hanein D, Matsudaira P, DeRosier DJ (October 1997). "Evidence for a conformational change in actin induced by fimbrin (N375) binding". J. Cell Biol. 139 (2): 387–96. doi:10.1083/jcb.139.2.387. PMC 2139807. PMID 9334343.
- ^ Molecular Cell Biology Fifth Edition Lodish, Berk, Matsudaira, Kaiser, Krieger, Scott, Zipursky, Darnell. pg. 821, 823 2004 by W.H. Freeman and Company.
- ^ a b Ohta Y, Suzuki N, Nakamura S, Hartwig JH, Stossel TP (March 1999). "The small GTPase RalA targets filamin to induce filopodia". Proc. Natl. Acad. Sci. U.S.A. 96 (5): 2122–8. doi:10.1073/pnas.96.5.2122. PMC 26747. PMID 10051605.
- ^ a b Bentley D, Toroian-Raymond A (1986). "Disoriented pathfinding by pioneer neurone growth cones deprived of filopodia by cytochalasin treatment". Nature 323 (6090): 712–5. doi:10.1038/323712a0. PMID 3773996.
- ^ Beardsley, John (June 1999). "Getting Wired". Scientific American.
- ^ Maletic-Savatic, M.; Malinow R. (June 1999). "Rapid Dendritic Morphogenesis in CA1 Hippocampal Dendrites Induced by Synaptic Activity". Science. doi:10.1126/science.283.5409.1923.
- ^ Kress H, Stelzer EH, Holzer D, Buss F, Griffiths G, Rohrbach A (2007). "Filopodia act as phagocytic tentacles and pull with discrete steps and a load-dependent velocity". Proc. Natl. Acad. Sci. U.S.A. 104 (28): 11633–11638. doi:10.1073/pnas.0702449104. PMC 1913848. PMID 17620618.
- ^ Thomas S, Popov VL, Walker DH (2010) Exit Mechanisms of the Intracellular Bacterium Ehrlichia" PLoS ONE 5(12) e15775. http://www.plosone.org/article/info:doi%2F10.1371%2Fjournal.pone.0015775
- ^ Lehmann MJ, Sherer NM, Marks CB, Pypaert M, Mothes W (2005). "Actin- and myosin-driven movement of viruses along filopodia precedes their entry into cells.". J Cell Biol 170 (2): 317–325. doi:10.1083/jcb.200503059. PMC 2171413. PMID 16027225.
- ^ Lidke, DS; Lidke, KA; Rieger, B; Jovin, TM; Arndt-Jovin, DJ (Aug 15, 2005). "Reaching out for signals: filopodia sense EGF and respond by directed retrograde transport of activated receptors.". The Journal of Cell Biology 170 (4): 619–26. doi:10.1083/jcb.200503140. PMC 2171515. PMID 16103229.
External links
- MBInfo - Filopodia
- MBInfo - Filopodia Assembly
- [1]
UpToDate Contents
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English Journal
- IRSp53/BAIAP2 in dendritic spine development, NMDA receptor regulation, and psychiatric disorders.
- Kang J1, Park H1, Kim E2.
- Neuropharmacology.Neuropharmacology.2016 Jan;100:27-39. doi: 10.1016/j.neuropharm.2015.06.019. Epub 2015 Aug 12.
- IRSp53 (also known as BAIAP2) is a multi-domain scaffolding and adaptor protein that has been implicated in the regulation of membrane and actin dynamics at subcellular structures, including filopodia and lamellipodia. Accumulating evidence indicates that IRSp53 is an abundant component of the posts
- PMID 26275848
- Cx43 increases serum induced filopodia formation via activation of p21-activated protein kinase 1.
- Kameritsch P1, Kiemer F2, Beck H3, Pohl U4, Pogoda K5.
- Biochimica et biophysica acta.Biochim Biophys Acta.2015 Nov;1853(11 Pt A):2907-17. doi: 10.1016/j.bbamcr.2015.08.004. Epub 2015 Aug 5.
- In a previous study we could show that connexin 43 (Cx43) expression increased the migration of cells in a channel-independent manner involving the MAPK p38. We analyzed here the mechanism by which Cx43 enhanced p38 activation and migration related changes of the actin cytoskeleton. HeLa cells were
- PMID 26255026
- Neuronal and metastatic cancer cells: Unlike brothers.
- Heine P1, Ehrlicher A2, Käs J3.
- Biochimica et biophysica acta.Biochim Biophys Acta.2015 Nov;1853(11 Pt B):3126-31. doi: 10.1016/j.bbamcr.2015.06.011. Epub 2015 Jun 26.
- During development neuronal cells traverse substantial distances across the developing tissue. In the mature organism, however, they are bound to the confines of the nervous system. Likewise metastatic cancer cells have the potential to establish auxiliary tumor sites in remote tissues or entirely d
- PMID 26119327
Japanese Journal
- Subtype specific roles of serotonin receptors in the spine formation of cortical neurons in vitro
- Yoshida Hiroyuki,Kanamaru Chisako,Ohtani Akiko,Li Fei,Senzaki Kouji,Shiga Takashi,先崎 浩次,志賀 隆
- Neuroscience research 71(3), 311-314, 2011-11
- … Dendritic spines are postsynaptic structures which are formed from filopodia. … At 11 days in vitro, 5-HT1A agonist increased filopodia density, whereas 5-HT2A/2C agonist increased the density of puncta and spines. … At 15 days in vitro, 5-HT1A agonist decreased the density of puncta and spines, whereas 5-HT2A/2C agonist decreased filopodia density with increase of spines. …
- NAID 80022070869
- Differential roles of calcitonin family peptides in the dendrite formation and spinogenesis of the cerebral cortex in vitro
- Harigai Yuichi,Natsume Masaki,Li Fei,Ohtani Akiko,Senzaki Kouji,Shiga Takashi,先崎 浩次,志賀 隆
- Neuropeptides 45(4), 263-272, 2011-08
- … The density of filopodia, puncta/stubby spines and spines were increased by the CGRP treatment, whereas decreased by amylin. … Therefore, CGRP and amylin showed opposite effects on the formation of dendritic filopodia, puncta and spines. …
- NAID 120003518137
Related Links
- fil·o·po·di·um / ˌfɪl əˈpoʊ di əm, ˌfaɪ lə-/ Show Spelled [fil-uh-poh-dee-uh m, fahy-l uh-] Show IPA noun, plural fil·o·po·di·a / ˌfɪl əˈpoʊ di ə, ˌfaɪ lə-/ Show Spelled [fil-uh-poh-dee-uh, fahy-l uh-] Show IPA. Cell Biology. a long, hairlike ...
- 1. Nat Rev Mol Cell Biol. 2008 Jun;9(6):446-54. doi: 10.1038/nrm2406. Epub 2008 May 9. Filopodia: molecular architecture and cellular functions. Mattila PK, Lappalainen P. Cancer Research UK London Research Institute, 44 Lincoln ...
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葉状仮足、膜状仮足、ラメリポディア
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- filopodia、lamellipodium、lobopodia、lobopodium、pseudopodia、pseudopodium
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- 英
- filopodium、filopodia、filopodial
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- 仮足、膜状仮足、葉状仮足、フィロポディア
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葉状仮足
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- filopodia、lamellipodia、lamellipodium、lobopodium、pseudopodia、pseudopodium
[★]
仮足
- 関
- filopodia、lamellipodia、lobopodia、pseudopodium
[★]
仮足
- 関
- filopodia、lamellipodia、lobopodia、pseudopodia
[★]
- 関
- filopodia、filopodium