adj.

線維性の

関: fibrous

WordNet

(of meat) full of sinews; especially impossible to chew (同)sinewy, stringy, unchewable

PrepTutorEJDIC

繊維の,繊維状(質)の

Wikipedia preview

出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2013/08/28 18:08:52」(JST)

wiki en

[Wiki en表示]

Fibrosis is the formation of excess fibrous connective tissue in an organ or tissue in a reparative or reactive process. This can be a reactive, benign, or pathological state. In response to injury this is called scarring and if fibrosis arises from a single cell line this is called a fibroma. Physiologically this acts to deposit connective tissue, which can obliterate the architecture and function of the underlying organ or tissue. Fibrosis can be used to describe the pathological state of excess deposition of fibrous tissue, as well as the process of connective tissue deposition in healing.^[1]

Physiology[edit source | edit]

Fibrosis is similar to the process of scarring, in that both involve stimulated cells laying down connective tissue, including collagen and glycosaminoglycans. Immune cells called Macrophages, and damaged tissue between surfaces called interstitium release TGFbeta. This can be because of numerous reasons, including inflammation of the nearby tissue, or a generalised inflammatory state, with increased circulating mediators. TGFbeta stimulates the proliferation and activation of fibroblasts, which deposit connective tissue.^[2]

Examples of fibrosis[edit source | edit]

Fibrosis can occur in many tissues within the body, typically as a result of inflammation or damage, and examples include:

Micrograph showing cirrhosis of the liver. The tissue in this example is stained with a trichrome stain, in which fibrosis is colored blue. The red areas are the nodular liver tissue

Lungs

Pulmonary fibrosis (lungs)
- Idiopathic pulmonary fibrosis (where the cause is unknown)
- Cystic fibrosis
Cirrhosis (liver)

Heart

Endomyocardial fibrosis (heart)
Old myocardial infarction (heart)
Atrial Fibrosis (heart)

Other

Mediastinal fibrosis (soft tissue of the mediastinum)
Myelofibrosis (bone marrow)
Retroperitoneal fibrosis (soft tissue of the retroperitoneum)
Progressive massive fibrosis (lungs); a complication of coal workers' pneumoconiosis
Nephrogenic systemic fibrosis (skin)
Crohn's Disease (intestine)
Keloid (skin)
Scleroderma/systemic sclerosis (skin, lungs)
Arthrofibrosis (knee, shoulder, other joints)
Some forms of adhesive capsulitis (shoulder)

References[edit source | edit]

^ Glossary of dermatopathological terms. DermNet NZ
^ Trojanowska, Maria (2012). Open Rheumatol J. 6: 70–71. PMID PMC3395879.

External links[edit source | edit]

International Scar Meeting in Tokyo 2010 International Scar Meeting

...

UpToDate Contents

全文を閲覧するには購読必要です。 To read the full text you will need to subscribe.

1. 特発性肺線維症の病因 pathogenesis of idiopathic pulmonary fibrosis
2. 特発性間質性肺炎：臨床症状および病理 idiopathic interstitial pneumonias clinical manifestations and pathology
3. 子宮平滑筋腫（子宮筋腫）の組織学的検査および病因 histology and pathogenesis of uterine leiomyomas fibroids
4. 間質性肺疾患における肺生検結果の解釈 interpretation of lung biopsy results in interstitial lung disease
5. 肝線維症の病因 pathogenesis of hepatic fibrosis

English Journal

Mucosal remodeling and reversibility in chronic rhinosinusitis.

Bassiouni A, Chen PG, Wormald PJ.SourceDepartment of Surgery - Otorhinolaryngology, Head & Neck Surgery, University of Adelaide, Adelaide, South Australia, Australia.
Current opinion in allergy and clinical immunology.Curr Opin Allergy Clin Immunol.2013 Feb;13(1):4-12. doi: 10.1097/ACI.0b013e32835ad09e.
PURPOSE OF REVIEW: Evidence suggests that some structural changes caused by mucosal remodeling may be primarily irreversible, which theoretically challenges the current management model of chronic rhinosinusitis (CRS). The relationship between inflammation and remodeling in the mucosa remains comple
PMID 23222070

Visualising liver fibrosis by phase-contrast X-ray imaging in common bile duct ligated mice.

Zhang X, Yang XR, Chen Y, Li HQ, Li RM, Yuan QX, Zhu PP, Huang WX, Peng WJ.SourceDepartment of Radiology, Affiliated Cancer Hospital of Fudan University, 270 Dongan Road, Shanghai, 200032, China.
European radiology.Eur Radiol.2013 Feb;23(2):417-23. doi: 10.1007/s00330-012-2630-z. Epub 2012 Aug 19.
OBJECTIVES: To determine whether phase-contrast X-ray imaging can be used to visualise directly the accumulated extracellular matrix proteins associated with liver fibrosis in common bile duct ligated mice.METHODS: Twenty-six-week-old C57BL female mice were randomised into three groups. In groups 1
PMID 22903640

Proangiogenic hematopoietic cells of monocytic origin: roles in vascular regeneration and pathogenic processes of systemic sclerosis.

Yamaguchi Y, Kuwana M.SourceDepartment of Environmental Immuno-Dermatology, Yokohama City University Graduate School of Medicine, Yokohama, Japan.
Histology and histopathology.Histol Histopathol.2013 Feb;28(2):175-83.
New blood vessel formation is critical, not only for organ development and tissue regeneration, but also for various pathologic processes, such as tumor development and vasculopathy. The maintenance of the postnatal vascular system requires constant remodeling, which occurs through angiogenesis, vas
PMID 23275301

Japanese Journal

Pathogenetic role of an autoimmune susceptibility locus derived from MRL/MpJ strain chromosome 1 in chronic pancreas inflammation

Okada Yuki,Nakamura Teppei,Ichii Osamu,Otsuka Saori,Kon Yasuhiro
Lupus 23(11), 1112-1123, 2014-10
… No strain-specific differences were observed in the appearance of fibrotic lesions and high endothelial venules in the cell infiltrates. …
NAID 120005476208

腎臓の線維化とその治療 (第111回日本内科学会講演会(2014年)未来の医療を創造する内科学) -- (シンポジウム臓器の線維化とその治療)

岡田浩一
日本内科学会雑誌 103(9), 2176-2182, 2014-09-10
NAID 40020212864

Autopsy analyses in acute exacerbation of idiopathic pulmonary fibrosis

Oda Keishi,Ishimoto Hiroshi,Yamada Sohsuke,Kushima Hisako,Ishii Hiroshi,Imanaga Tomotoshi,Harada Tatsuhiko,Ishimatsu Yuji,Matsumoto Nobuhiro,Naito Keisuke,Yatera Kazuhiro,Nakazato Masamitsu,Kadota Jun-ichi,Watanabe Kentaro,Kohno Shigeru,Mukae Hiroshi
Respiratory Research 15(1), 109, 2014-09-01
… The underling fibrotic lesion was classified as having the usual interstitial pneumonia (UIP) pattern in all cases. …
NAID 120005477088

Related Pictures

★リンクテーブル★

リンク元	「fibrous」「線維性」

「fibrous」

Fibrosis
	Classification and external resources
	; Micrograph of a heart showing fibrosis (yellow - left of image) and amyloid deposition (brown - right of image). Movat's stain.
MeSH	D005355

　　[★]

adj.

線維性の、線維状の

関: fibrotic、filamentous

「線維性」

　　[★]

英: fibrous、fibrotic
関: 線維状

[1] Glossary of dermatopathological terms. DermNet NZ

[Mediators_of_Fibrosis-2] Trojanowska, Maria (2012). Open Rheumatol J. 6: 70–71. PMID PMC3395879.

匿名

検索

案内

案内

fibrotic