WordNet

bushy aromatic European perennial herb having clusters of buttonlike white-rayed flower heads; valued traditionally for medicinal uses; sometimes placed in genus Chrysanthemum (同)Tanacetum_parthenium, Chrysanthemum parthenium
stout perennial herb of the eastern United States with whitish flowers; leaves traditionally used by Catawba Indians to treat burns (同)wild quinine, prairie dock, Parthenium integrifolium
tropical American annual weed with small radiate heads of white flowers; adventive in southern United States (同)Parthenium hysterophorus

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出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2017/01/26 17:13:11」(JST)

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Tanacetum parthenium, the feverfew,^[1] is a traditional medicinal herb which is commonly used to prevent migraine headaches, and is also occasionally grown for ornament. It is also commonly seen in the literature by its synonyms, Chrysanthemum parthenium and Pyrethrum parthenium. It is also sometimes referred to as bachelor's buttons or featherfew.^[2]

Description

The plant is covered by flowers reminiscent of daisies and grows into a small bush^[2] up to around 46 cm (18 in) high with citrus-scented leaves. It spreads rapidly, and will cover a wide area after a few years. The species grows to up to 60 cm high. The leaves are variously pinnatifid with conspicuous flowers up to 20 mm across. The outer florets are all ligulate and white. The inner florets are yellow and tubular in lax corymbs.^[3]^[4]

Distribution and Cultivation

A perennial herb, which should be planted in full sun, 38 to 46 cm (15–18 in) apart and cut back to the ground in the autumn. It grows up to 61 cm (24 in) tall. It is hardy to USDA zone 5 (−30 °C (−22 °F)). Outside of its native range it can become an invasive weed. Feverfew was native to Eurasia: specifically the Balkan Peninsula, Anatolia and the Caucasus, but cultivation has spread it around the world and it is now also found in the rest of Europe, North America and Chile.^[5]

Uses

Leaf of feverfew

Feverfew has been used as a herbal treatment to reduce fever and to treat headaches, arthritis^[6] and digestive problems.^[7]^[8]^[9]

Parthenolide

The active ingredients in feverfew include parthenolide.^[10] There has been some scientific interest in parthenolide, which has been shown to induce apoptosis in some cancer cell lines in vitro and potentially to target cancer stem cells.^[11]^[12]^[13] There are no published studies of parthenolide or feverfew in humans with cancer. The parthenolide content of commercially available feverfew supplements varies substantially, by over 40-fold, despite labeling claims of "standardization". A study found that the actual parthenolide content of these supplements bore little resemblance to the content claimed on the product label.^[14]

Long-term use of feverfew followed by abrupt discontinuation may induce a withdrawal syndrome featuring rebound headaches and muscle and joint pains.^[15] Feverfew can cause allergic reactions, including contact dermatitis.^[16] Other side effects have included gastrointestinal upset such as nausea, vomiting, abdominal pain, diarrhea, and flatulence. When the herb is chewed or taken orally it can cause mouth ulcers and swelling and numbness of the mouth.^[15] Feverfew should not be taken by pregnant women.^[17] It may interact with blood thinners and increase the risk of bleeding, and may also interact with a variety of medications metabolized by the liver.^[15]

History

The word "feverfew" derives from the Latin word febrifugia, meaning "fever reducer".^[15] although it is no longer considered useful for that purpose. Though its earliest medicinal use is unknown, it was documented in the first century (AD) as an anti-inflammatory by the Greek herbalist physician Dioscorides.^[18]

References

^ "Tanacetum parthenium". Natural Resources Conservation Service PLANTS Database. USDA. Retrieved 8 December 2015.
^ ^a ^b National Center for Complementary and Integrative Health. "FeverFew". Retrieved 18 July 2012.
^ Parnell, J. and Curtis. 2012. Webb's An Irish Flora. Cork University Press. ISBN 978-185918-4783
^ Clapham, A.R, Tutin, T.G. and Warburg, E.F. 1968. Excursion Flora of the British Isles. Cambridge University Press. ISBN 0-521-04656-4
^ Jeffrey C (2001). "Tanacetum parthenium". Mansfeld's World Database of Agricultural and Horticultural Crops.
^ University of Maryland Medical Center. "Feverfew". Retrieved 18 July 2012.
^ Pittler MH, Ernst E (2004). "Feverfew for preventing migraine". Cochrane Database of Systematic Reviews (1): CD002286. doi:10.1002/14651858.CD002286.pub2. PMID 14973986.
^ "Feverfew". National Center for Complementary and Integrative Health. July 2010. Retrieved October 6, 2011.
^ Pareek A, Suthar M, Rathore GS, Bansal V (January 2011). "Feverfew (Tanacetum parthenium L.): A systematic review". Pharmacogn Rev. 5 (9): 103–10. doi:10.4103/0973-7847.79105. PMC 3210009. PMID 22096324.
^ Meschino Health. "Comprehensive Guide to Feverfew". Retrieved 18 July 2012.
^ Guzman ML, Rossi RM, Karnischky L, et al. (June 2005). "The sesquiterpene lactone parthenolide induces apoptosis of human acute myelogenous leukemia stem and progenitor cells". Blood. 105 (11): 4163–9. doi:10.1182/blood-2004-10-4135. PMC 1895029. PMID 15687234.
^ Guzman ML, Jordan CT (September 2005). "Feverfew: weeding out the root of leukaemia". Expert Opin Biol Ther. 5 (9): 1147–52. doi:10.1517/14712598.5.9.1147. PMID 16120045.
^ Lesiak K, Koprowska K, Zalesna I, Nejc D, Düchler M, Czyz M (February 2010). "Parthenolide, a sesquiterpene lactone from the medical herb feverfew, shows anticancer activity against human melanoma cells in vitro". Melanoma Res. 20 (1): 21–34. doi:10.1097/CMR.0b013e328333bbe4. PMID 19949351.
^ Draves AH, Walker SE (2004). "Parthenolide content of Canadian commercial feverfew preparations: Label claims are misleading in most cases" (PDF). Canadian Pharmacists Journal. 136 (10): 23–30.
^ ^a ^b ^c ^d "Feverfew". University of Maryland. Retrieved 6 October 2011.
^ Killoran, CE; Crawford, GH; Pedvis-Leftick, A (2007). "Two cases of compositae dermatitis exacerbated by moisturizer containing feverfew". Dermatitis : contact, atopic, occupational, drug. 18 (4): 225–9. PMID 18021604.
^ Yao M, Ritchie HE, Brown-Woodman PD (November 2006). "A reproductive screening test of feverfew: is a full reproductive study warranted?". Reprod. Toxicol. 22 (4): 688–93. doi:10.1016/j.reprotox.2006.04.014. PMID 16781113.
^ "Agricultural (Herbs and Spices): Feverfew Information". Government of Saskatchewan. Retrieved 6 January 2012.

External links

Feverfew information from the National Center for Complementary and Integrative Health
Feverfew in A Modern Herbal

UpToDate Contents

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1. 成人における片頭痛の予防的治療 preventive treatment of migraine in adults
2. 漢方薬および栄養補助食品の概要 overview of herbal medicine and dietary supplements
3. 慢性片頭痛 chronic migraine
4. 小児における補完剤および代替剤の概要 overview of complementary and alternative medicine in pediatrics
5. リウマチ性疾患に対する補完・代替療法 complementary and alternative remedies for rheumatic disorders

English Journal

Convergence chromatographic determination of camphor in the essential oil of Tanacetum parthenium L.

Végh K1, Riethmüller E2, Tóth A1, Alberti Á1, Béni S1, Balla J3, Kéry Á1.
Biomedical chromatography : BMC.Biomed Chromatogr.2016 Jun 20. doi: 10.1002/bmc.3781. [Epub ahead of print]
Feverfew (Tanacetum parthenium L., Asteraceae) is a perennial medicinal plant which has been used to alleviate the symptoms of migraine, headache, rheumatoid arthritis and possesses numerous pharmacological activities. An Ultra high performance supercritical fluid chromatographic method (UHPSFC) was
PMID 27324458

Parthenolide ameliorates Concanavalin A-induced acute hepatitis in mice and modulates the macrophages to an anti-inflammatory state.

Wang D1, Wang H2, Fu S3, Cheng X3, Yang F3, Zhang Q3, Li Y3, Xue Z3, Zhang L3, Huang W4, Yang L2, Na D2, Da Y3, Kong Y5, Zhang R6.
International immunopharmacology.Int Immunopharmacol.2016 Jun 4;38:132-138. doi: 10.1016/j.intimp.2016.05.024. [Epub ahead of print]
Parthenolide, the principal sesquiterpene lactone present in medicinal plants such as feverfew, has anti-microbial, anti-inflammatory and anticancer activities. In the present study, we investigated the protective role of parthenolide against acute hepatitis in mice. Mice acute hepatitis were induce
PMID 27270078

Targeting Thioredoxin Reductase by Parthenolide Contributes to Inducing Apoptosis of HeLa Cells.

Duan D1, Zhang J2, Yao J2, Liu Y2, Fang J3.
The Journal of biological chemistry.J Biol Chem.2016 May 6;291(19):10021-31. doi: 10.1074/jbc.M115.700591. Epub 2016 Mar 21.
Parthenolide (PTL), a major active sesquiterpene lactone from the herbal plant Tanacetum parthenium, has been applied in traditional Chinese medicine for centuries. Although PTL demonstrates potent anticancer efficacy in numerous types of malignant cells, the cellular targets of PTL have not been we
PMID 27002142

A Critical Approach to Evaluating Clinical Efficacy, Adverse Events and Drug Interactions of Herbal Remedies.

Izzo AA1, Hoon-Kim S2, Radhakrishnan R3, Williamson EM4.
Phytotherapy research : PTR.Phytother Res.2016 May;30(5):691-700. doi: 10.1002/ptr.5591. Epub 2016 Feb 17.
Systematic reviews and meta-analyses represent the uppermost ladders in the hierarchy of evidence. Systematic reviews/meta-analyses suggest preliminary or satisfactory clinical evidence for agnus castus (Vitex agnus castus) for premenstrual complaints, flaxseed (Linum usitatissimum) for hypertension
PMID 26887532

Japanese Journal

免疫疾患の新たな分子標的治療NFκB阻害薬

日本臨床免疫学会会誌 = Japanese journal of clinical immunology 32(2), 71-76, 2009-04-28
NAID 10024961989

Effects of Sesquiterpene Lactones on Melanogenesis in Mouse B16 Melanoma Cells(Biopharmacy)

Biological & pharmaceutical bulletin 32(2), 308-310, 2009-02-01
NAID 110007042145

関節リウマチに対するサプリメントの位置付け

日本関節病学会誌 28(2), 189-197, 2009
NAID 130004567892

Fusarium oxysporum f. sp. tanacetiによるナツシロギク萎凋病(新称)

日本植物病理學會報 74(1), 7-12, 2008-02-20
NAID 110006644543

Related Pictures

★リンクテーブル★

リンク元	「ナツシロギク」「Tanacetum parthenium」

「ナツシロギク」

Feverfew
Scientific classification
Kingdom:	Plantae
(unranked):	Angiosperms
(unranked):	Eudicots
(unranked):	Asterids
Order:	Asterales
Family:	Asteraceae
Genus:	Tanacetum
Species:	T. parthenium
Binomial name
	Tanacetum parthenium; (L.) Sch. Bip.
Synonyms
	Chrysanthemum parthenium (L.) Bernh.; Matricaria parthenium L.; Pyrethrum parthenium (L.) Sm.;

　　[★]

英: feverfew、Tanacetum parthenium
関: マトリカリア

「Tanacetum parthenium」

　　[★]

ナツシロギク、マトリカリア

関: feverfew

[1] "Tanacetum parthenium". Natural Resources Conservation Service PLANTS Database. USDA. Retrieved 8 December 2015.

[NCCIH-2] National Center for Complementary and Integrative Health. "FeverFew". Retrieved 18 July 2012.

[3] Parnell, J. and Curtis. 2012. Webb's An Irish Flora. Cork University Press. ISBN 978-185918-4783

[4] Clapham, A.R, Tutin, T.G. and Warburg, E.F. 1968. Excursion Flora of the British Isles. Cambridge University Press. ISBN 0-521-04656-4

[5] Jeffrey C (2001). "Tanacetum parthenium". Mansfeld's World Database of Agricultural and Horticultural Crops.

[6] University of Maryland Medical Center. "Feverfew". Retrieved 18 July 2012.

[7] Pittler MH, Ernst E (2004). "Feverfew for preventing migraine". Cochrane Database of Systematic Reviews (1): CD002286. doi:10.1002/14651858.CD002286.pub2. PMID 14973986.

[nccam-8] "Feverfew". National Center for Complementary and Integrative Health. July 2010. Retrieved October 6, 2011.

[9] Pareek A, Suthar M, Rathore GS, Bansal V (January 2011). "Feverfew (Tanacetum parthenium L.): A systematic review". Pharmacogn Rev. 5 (9): 103–10. doi:10.4103/0973-7847.79105. PMC 3210009. PMID 22096324.

[10] Meschino Health. "Comprehensive Guide to Feverfew". Retrieved 18 July 2012.

[11] Guzman ML, Rossi RM, Karnischky L, et al. (June 2005). "The sesquiterpene lactone parthenolide induces apoptosis of human acute myelogenous leukemia stem and progenitor cells". Blood. 105 (11): 4163–9. doi:10.1182/blood-2004-10-4135. PMC 1895029. PMID 15687234.

[12] Guzman ML, Jordan CT (September 2005). "Feverfew: weeding out the root of leukaemia". Expert Opin Biol Ther. 5 (9): 1147–52. doi:10.1517/14712598.5.9.1147. PMID 16120045.

[13] Lesiak K, Koprowska K, Zalesna I, Nejc D, Düchler M, Czyz M (February 2010). "Parthenolide, a sesquiterpene lactone from the medical herb feverfew, shows anticancer activity against human melanoma cells in vitro". Melanoma Res. 20 (1): 21–34. doi:10.1097/CMR.0b013e328333bbe4. PMID 19949351.

[cjp-14] Draves AH, Walker SE (2004). "Parthenolide content of Canadian commercial feverfew preparations: Label claims are misleading in most cases" (PDF). Canadian Pharmacists Journal. 136 (10): 23–30.

[umn-15] "Feverfew". University of Maryland. Retrieved 6 October 2011.

[16] Killoran, CE; Crawford, GH; Pedvis-Leftick, A (2007). "Two cases of compositae dermatitis exacerbated by moisturizer containing feverfew". Dermatitis : contact, atopic, occupational, drug. 18 (4): 225–9. PMID 18021604.

[pmid16781113-17] Yao M, Ritchie HE, Brown-Woodman PD (November 2006). "A reproductive screening test of feverfew: is a full reproductive study warranted?". Reprod. Toxicol. 22 (4): 688–93. doi:10.1016/j.reprotox.2006.04.014. PMID 16781113.

[18] "Agricultural (Herbs and Spices): Feverfew Information". Government of Saskatchewan. Retrieved 6 January 2012.

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