farnesyltranstransferase

• ファルネシル基トランス転移酵素、ファルネシルトランストランスフェラーゼ

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farnesyltransferase

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出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2015/01/22 15:18:22」(JST)

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farnesyltranstransferase
Identifiers
EC number	2.5.1.29
CAS number	9032-58-0
Databases
IntEnz	IntEnz view
BRENDA	BRENDA entry
ExPASy	NiceZyme view
KEGG	KEGG entry
MetaCyc	metabolic pathway
PRIAM	profile
PDB structures	RCSB PDB PDBe PDBsum
Gene Ontology	AmiGO / EGO
Search PMC articles PubMed articles NCBI proteins

In enzymology, a farnesyltranstransferase (EC 2.5.1.29) is an enzyme that catalyzes the chemical reaction

trans,trans-farnesyl diphosphate + isopentenyl diphosphate diphosphate + geranylgeranyl diphosphate

Thus, the two substrates of this enzyme are trans,trans-farnesyl diphosphate and isopentenyl diphosphate, whereas its two products are diphosphate and geranylgeranyl diphosphate.

This enzyme belongs to the family of transferases, specifically those transferring aryl or alkyl groups other than methyl groups. The systematic name of this enzyme class is trans,trans-farnesyl-diphosphate:isopentenyl-diphosphate farnesyltranstransferase. Other names in common use include geranylgeranyl-diphosphate synthase, geranylgeranyl pyrophosphate synthetase, geranylgeranyl-PP synthetase, farnesyltransferase, and geranylgeranyl pyrophosphate synthase. This enzyme participates in biosynthesis of steroids and terpenoid biosynthesis.

This protein may use the morpheein model of allosteric regulation.

Structural studies

As of late 2007, two structures have been solved for this class of enzymes, with PDB accession codes 2DH4 and 2Q80.

References

• Sagami H, Ishi K and Ogura K (1981). "Occurrence and unusual properties of geranylgeranyl pyrophosphate synthetase of pig liver". Biochem. Int. 3: 669–675. 

English Journal

• In vitro studies in a myelogenous leukemia cell line suggest an organized binding of geranylgeranyl diphosphate synthase inhibitors.

• Reilly JE1, Zhou X2, Tong H3, Kuder CH4, Wiemer DF5, Hohl RJ6.
• Biochemical pharmacology.Biochem Pharmacol.2015 Jul 15;96(2):83-92. doi: 10.1016/j.bcp.2015.04.009. Epub 2015 May 4.
• A small set of isoprenoid bisphosphonates ethers has been tested in the K562 chronic myelogenous leukemia cell line to determine their impact on isoprenoid biosynthesis. Five of these compounds inhibit geranylgeranyl diphosphate synthase (GGDPS) with IC50 values below 1 μM in enzyme assays, but in
• PMID 25952057

• GGPPS deficiency aggravates CCl4-induced liver injury by inducing hepatocyte apoptosis.

• Chen WB1, Lai SS2, Yu DC3, Liu J2, Jiang S2, Zhao DD2, Ding YT4, Li CJ5, Xue B6.
• FEBS letters.FEBS Lett.2015 Apr 28;589(10):1119-26. doi: 10.1016/j.febslet.2015.03.015. Epub 2015 Mar 24.
• GGPPS catalyses the expression of GGPP, a key protein in the mevalonate metabolic pathway. HMG-CoA reductase inhibitor statins can induce liver injury by inhibiting GGPP. However, the function of GGPPS in liver injury has not yet been revealed. In this study, we found that GGPPS increased in liver i
• PMID 25819439

• The alteration of protein prenylation induces cardiomyocyte hypertrophy through Rheb-mTORC1 signalling and leads to chronic heart failure.

• Xu N1, Guan S, Chen Z, Yu Y, Xie J, Pan FY, Zhao NW, Liu L, Yang ZZ, Gao X, Xu B, Li CJ.
• The Journal of pathology.J Pathol.2015 Apr;235(5):672-85. doi: 10.1002/path.4480. Epub 2015 Jan 7.
• G protein-regulated cell function is crucial for cardiomyocytes, and any deregulation of its gene expression or protein modification can lead to pathological cardiac hypertrophy. Herein, we report that protein prenylation, a lipidic modification of G proteins that facilitates their association with
• PMID 25385233

Related Links

• Amazon.co.jp： Farnesyltranstransferase: Nethanel Willy: 洋書

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• Farnesyltranstransferase - ResearchGate

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リンク元	「ファルネシルトランストランスフェラーゼ」「farnesyltransferase」「ファルネシル基トランス転移酵素」

「ファルネシルトランストランスフェラーゼ」

　　[★]

英

farnesyltranstransferase

関

ファルネシルトランスフェラーゼ、ファルネシル基トランス転移酵素

「farnesyltransferase」

　　[★]

ファルネシルトランスフェラーゼ、ファルネシル基転移酵素

関

farnesyltranstransferase

「ファルネシル基トランス転移酵素」

　　[★]

英

farnesyltranstransferase

関

ファルネシルトランストランスフェラーゼ