UpToDate Contents

全文を閲覧するには購読必要です。 To read the full text you will need to subscribe.

English Journal

mTor mediates tau localization and secretion: Implication for Alzheimer's disease.

Tang Z1, Ioja E2, Bereczki E2, Hultenby K3, Li C2, Guan Z4, Winblad B2, Pei JJ5.
Biochimica et biophysica acta.Biochim Biophys Acta.2015 Jul;1853(7):1646-57. doi: 10.1016/j.bbamcr.2015.03.003. Epub 2015 Mar 17.
Abnormally hyperphosphorylated tau aggregates form paired helical filaments (PHFs) in neurofibrillary tangles, a key hallmark of Alzheimer's disease (AD) and other tauopathies. The cerebrospinal fluid (CSF) levels of soluble total tau and phospho-tau from clinically diagnosed AD patients are signifi
PMID 25791428

Syntaxin-4 mediates exocytosis of pre-docked and newcomer insulin granules underlying biphasic glucose-stimulated insulin secretion in human pancreatic beta cells.

Xie L1, Zhu D, Dolai S, Liang T, Qin T, Kang Y, Xie H, Huang YC, Gaisano HY.
Diabetologia.Diabetologia.2015 Jun;58(6):1250-9. doi: 10.1007/s00125-015-3545-4. Epub 2015 Mar 13.
AIMS/HYPOTHESIS: Of the four exocytotic syntaxins (Syns), much is now known about the role of Syn-1A (pre-docked secretory granules [SGs]) and Syn-3 (newcomer SGs) in insulin exocytosis. Some work was reported on Syn-4's role in biphasic glucose-stimulated insulin secretion (GSIS), but its precise r
PMID 25762204

Progressive dopaminergic alterations and mitochondrial abnormalities in LRRK2 G2019S knock-in mice.

Yue M1, Hinkle KM1, Davies P2, Trushina E3, Fiesel FC1, Christenson TA4, Schroeder AS3, Zhang L3, Bowles E1, Behrouz B1, Lincoln SJ1, Beevers JE1, Milnerwood AJ5, Kurti A1, McLean PJ6, Fryer JD6, Springer W6, Dickson DW6, Farrer MJ5, Melrose HL7.
Neurobiology of disease.Neurobiol Dis.2015 Jun;78:172-95. doi: 10.1016/j.nbd.2015.02.031. Epub 2015 Mar 31.
Mutations in the LRRK2 gene represent the most common genetic cause of late onset Parkinson's disease. The physiological and pathological roles of LRRK2 are yet to be fully determined but evidence points towards LRRK2 mutations causing a gain in kinase function, impacting on neuronal maintenance, ve
PMID 25836420

Effects of Repeated Administration of Pilocarpine and Isoproterenol on Aquaporin-5 Expression in Rat Salivary Glands

Susa Taketo,Sawai Nobuhiko,Aoki Takeo,Iizuka-Kogo Akiko,Kogo Hiroshi,Negishi Akihide,Yokoo Satoshi,Takata Kuniaki,Matsuzaki Toshiyuki
ACTA HISTOCHEMICA ET CYTOCHEMICA, 2013
… To address the possible mechanism of the elevation of AQP5 abundance in IPR-administered animals, changes of AQP5 level in fasting animals, in which the exocytotic events are reduced, were examined. … These results suggested that the elevation of cAMP and/or frequent exocytotic events could increase AQP5 protein. …
NAID 130003381873

Multiple Exocytotic Markers Accumulate at the Sites of Perifungal Membrane Biogenesis in Arbuscular Mycorrhizas

Possible Involvement of Glutamatergic Signaling Machineries in Pathophysiology of Rheumatoid Arthritis

Hinoi Eiichi,Yoneda Yukio
Journal of pharmacological sciences 116(3), 248-256, 2011-07-20
… These include Glu receptors for signal input, Glu transporters for signal termination, and vesicular Glu transporters for signal output through exocytotic release. …
NAID 10029894955