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出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2013/03/12 01:22:18」(JST)

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1. 甲状腺機能正常型高サイロキシン血症および低サイロキシン血症 euthyroid hyperthyroxinemia and hypothyroxinemia
2. 潜在性甲状腺機能低下症 subclinical hypothyroidism
3. 甲状腺機能低下症の治療 treatment of hypothyroidism
4. 甲状腺機能亢進症の診断 diagnosis of hyperthyroidism
5. 甲状腺機能の臨床検査評価 laboratory assessment of thyroid function

English Journal

Hashimoto thyroiditis: Clinical and diagnostic criteria.

Caturegli P1, De Remigis A2, Rose NR3.Author information 1Department of Pathology, The Johns Hopkins University School of Medicine, Baltimore, MD, United States; Feinstone Department of Molecular Microbiology and Immunology, The Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, United States. Electronic address: pcat@jhmi.edu.2Department of Pathology, The Johns Hopkins University School of Medicine, Baltimore, MD, United States.3Department of Pathology, The Johns Hopkins University School of Medicine, Baltimore, MD, United States; Feinstone Department of Molecular Microbiology and Immunology, The Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, United States.AbstractHashimoto thyroiditis (HT), now considered the most common autoimmune disease, was described over a century ago as a pronounced lymphoid goiter affecting predominantly women. In addition to this classic form, several other clinico-pathologic entities are now included under the term HT: fibrous variant, IgG4-related variant, juvenile form, Hashitoxicosis, and painless thyroiditis (sporadic or post-partum). All forms are characterized pathologically by the infiltration of hematopoietic mononuclear cells, mainly lymphocytes, in the interstitium among the thyroid follicles, although specific features can be recognized in each variant. Thyroid cells undergo atrophy or transform into a bolder type of follicular cell rich in mitochondria called Hürthle cell. Most HT forms ultimately evolve into hypothyroidism, although at presentation patients can be euthyroid or even hyperthyroid. The diagnosis of HT relies on the demonstration of circulating antibodies to thyroid antigens (mainly thyroperoxidase and thyroglobulin) and reduced echogenicity on thyroid sonogram in a patient with proper clinical features. The treatment remains symptomatic and based on the administration of synthetic thyroid hormones to correct the hypothyroidism as needed. Surgery is performed when the goiter is large enough to cause significant compression of the surrounding cervical structures, or when some areas of the thyroid gland mimic the features of a nodule whose cytology cannot be ascertained as benign. HT remains a complex and ever expanding disease of unknown pathogenesis that awaits prevention or novel forms of treatment.
Autoimmunity reviews.Autoimmun Rev.2014 April - May;13(4-5):391-397. doi: 10.1016/j.autrev.2014.01.007. Epub 2014 Jan 13.
Hashimoto thyroiditis (HT), now considered the most common autoimmune disease, was described over a century ago as a pronounced lymphoid goiter affecting predominantly women. In addition to this classic form, several other clinico-pathologic entities are now included under the term HT: fibrous varia
PMID 24434360

Association between thyroid hormones and body fat in euthyroid subjects.

Ren R1, Jiang X, Zhang X, Guan Q, Yu C, Li Y, Gao L, Zhang H, Zhao J.Author information 1Department of Endocrinology, Provincial Hospital Affiliated to Shandong University, Jinan, China; Department of Endocrinology, Yantai Yuhuangding Hospital Affiliated to Qingdao University, Yantai, China.AbstractOBJECTIVE: Thyroid hormones disorders are associated with changes of body composition. However, the relationship between thyroid hormones and body fat in a euthyroid population is unclear. The aim of this study was to explore the association between thyroid hormones and body fat in a euthyriod population.
Clinical endocrinology.Clin Endocrinol (Oxf).2014 Apr;80(4):585-90. doi: 10.1111/cen.12311. Epub 2013 Sep 23.
OBJECTIVE: Thyroid hormones disorders are associated with changes of body composition. However, the relationship between thyroid hormones and body fat in a euthyroid population is unclear. The aim of this study was to explore the association between thyroid hormones and body fat in a euthyriod popul
PMID 23927635

Exercise-induced oxidative stress and hypoxic exercise recovery.

Ballmann C1, McGinnis G, Peters B, Slivka D, Cuddy J, Hailes W, Dumke C, Ruby B, Quindry J.Author information 1School of Kinesiology, Auburn University, Auburn, AL, 36830, USA.AbstractHypoxia due to altitude diminishes performance and alters exercise oxidative stress responses. While oxidative stress and exercise are well studied, the independent impact of hypoxia on exercise recovery remains unknown. Accordingly, we investigated hypoxic recovery effects on post-exercise oxidative stress. Physically active males (n = 12) performed normoxic cycle ergometer exercise consisting of ten high:low intensity intervals, 20 min at moderate intensity, and 6 h recovery at 975 m (normoxic) or simulated 5,000 m (hypoxic chamber) in a randomized counter-balanced cross-over design. Oxygen saturation was monitored via finger pulse oximetry. Blood plasma obtained pre- (Pre), post- (Post), 2 h post- (2Hr), 4 h post- (4Hr), and 6 h (6Hr) post-exercise was assayed for Ferric Reducing Ability of Plasma (FRAP), Trolox Equivalent Antioxidant Capacity (TEAC), Lipid Hydroperoxides (LOOH), and Protein Carbonyls (PC). Biopsies from the vastus lateralis obtained Pre and 6Hr were analyzed by real-time PCR quantify expression of Heme oxygenase 1 (HMOX1), Superoxide Dismutase 2 (SOD2), and Nuclear factor (euthyroid-derived2)-like factor (NFE2L2). PCs were not altered between trials, but a time effect (13 % Post-2Hr increase, p = 0.044) indicated exercise-induced blood oxidative stress. Plasma LOOH revealed only a time effect (p = 0.041), including a 120 % Post-4Hr increase. TEAC values were elevated in normoxic recovery versus hypoxic recovery. FRAP values were higher 6Hr (p = 0.045) in normoxic versus hypoxic recovery. Exercise elevated gene expression of NFE2L2 (20 % increase, p = 0.001) and SOD2 (42 % increase, p = 0.003), but hypoxic recovery abolished this response. Data indicate that recovery in a hypoxic environment, independent of exercise, may alter exercise adaptations to oxidative stress and metabolism.
European journal of applied physiology.Eur J Appl Physiol.2014 Apr;114(4):725-33. doi: 10.1007/s00421-013-2806-5. Epub 2014 Jan 3.
Hypoxia due to altitude diminishes performance and alters exercise oxidative stress responses. While oxidative stress and exercise are well studied, the independent impact of hypoxia on exercise recovery remains unknown. Accordingly, we investigated hypoxic recovery effects on post-exercise oxidativ
PMID 24384982

Japanese Journal

Prevalence and Influence of Hyperthyroidism on the Long-Term Outcome of Catheter Ablation for Drug-Refractory Atrial Fibrillation

MACHINO Takeshi,TADA Hiroshi,SEKIGUCHI Yukio,YAMASAKI Hiro,KUROKI Kenji,IGARASHI Miyako,NARUSE Yoshihisa,NAKANO Emi,ITO Yoko,KANESHIRO Takashi,YOSHIDA Kentaro,AONUMA Kazutaka
Circulation journal : official journal of the Japanese Circulation Society 76(11), 2546-2551, 2012-10-25
… however, one-third of patients remain in AF despite euthyroid restoration. … In the Hyperthyroid-AF patients, a euthyroid state had been restored for at least 3 months before the ablation. … After euthyroid restoration on pharmacological treatment, hyperthyroidism was not associated with a higher risk of AF recurrence. (Circ J 2012; …
NAID 10031078503

Depression in patients with euthyroid chronic autoimmune thyroiditis

KIRIM Sinan,KESKEK Sakir Ozgur,KOKSAL Fatma,HAYDARDEDEOGLU Filiz Eksi,BOZKIRLI Emre,TOLEDANO Yoel
Endocrine journal 59(8), 705-708, 2012-08-01
NAID 10031064711

Cardiac Autonomic Regulation Is Disturbed in Children with Euthyroid Hashimoto Thyroiditis

KILIC Ayhan,GULGUN Mustafa,TASCILAR Mehmet Emre,SARI Erkan,YOKUSOGLU Mehmet
Tohoku journal of experimental medicine 226(3), 191-195, 2012-03-01
NAID 10030197393

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