同: Edecrin

WordNet

street name for lysergic acid diethylamide (同)back breaker, battery-acid, dose, dot, Elvis, loony toons, Lucy in the sky with diamonds, pane, superman, window pane, Zen
any of various water-soluble compounds having a sour taste and capable of turning litmus red and reacting with a base to form a salt
having the characteristics of an acid; "an acid reaction"

PrepTutorEJDIC

酸性の / 酸味のある,すっぱい(sour) / (言葉・態度などが)厳しい,しんらつな / 酸 / すっぱいもの / 《俗》=LSD

Wikipedia preview

出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2015/08/03 21:25:30」(JST)

wiki en

Etacrynic acid (INN) or ethacrynic acid (USAN), trade name Edecrin, is a loop diuretic used to treat high blood pressure and the swelling caused by diseases like congestive heart failure, liver failure, and kidney failure.

Unlike the other loop diuretics, etacrynic acid is not a sulfonamide^[1] and thus, its use is not contraindicated in those with sulfa allergies.

Ethacrynic acid is a phenoxyacetic acid derivative containing a ketone group and a methylene group. A cysteine adduct is formed with the methylene group and this is the active form.

Administration

Ethacrynic acid is sold in 25 mg and 50 mg tablets for oral use. The sodium salt (ethacrynate sodium) can also be given intravenously. The IV solution must be prepared and maintained with a pH above 5.

Adverse effects

As a diuretic, ethacrynic acid can cause frequent urination, but this usually resolves after taking the drug for a few weeks.

Ethacrynic acid can also cause low potassium levels, which may manifest as muscle cramps or weakness. It has also been known to cause reversible or permanent hearing loss(ototoxicity)^[2] and liver damage^[3] when administered in extremely high dosages. On oral administration, it produces diarrhea; intestinal bleeding may occur at higher doses.

Mechanism of action

Ethacrynic acid acts by inhibiting sodium-potassium-chloride cotransport in the ascending loop of Henle. Loss of potassium ions is less marked but chances of hypochloremic alkalosis are greater. The dose response curve of ethacrynic acid is steeper than that of furosemide and, in general, it is less manageable; dose range is 50-150mg.

Ethacrynic acid and its glutathione-adduct are potent inhibitors of glutathione S-transferase family members, which are enzymes involved in xenobiotic metabolism. This family of enzymes has recently been shown to have a high rate of genetic variability.

References

^ Somberg JC, Molnar J; Molnar (January 2009). "The Pleiotropic Effects of Ethacrynic Acid". Am J Ther 16 (1): 102–4. doi:10.1097/MJT.0b013e3181961264. PMID 19142157.
^ Bosher SK (1980). "The nature of the ototoxic actions of ethacrynic acid upon the mammalian endolymph system. I. Functional aspects". Acta Otolaryngol. 89 (5–6): 407–18. doi:10.3109/00016488009127156. PMID 7446061.
^ Datey, KK; Deshmukh, SN; Dalvi, CP; Purandare, NM (1967). "Hepatocellular damage with ethacrynic acid". Br. Med. J. 3 (5558): 152–153. doi:10.1136/bmj.3.5558.152. PMC 1842848. PMID 6028103.

UpToDate Contents

全文を閲覧するには購読必要です。 To read the full text you will need to subscribe.

1. ループ利尿剤：最大有効量および主な副作用 loop diuretics maximum effective dose and major side effects
2. 利尿剤の作用機序 mechanism of action of diuretics
3. 非HIV感染患者におけるスルホンアミドアレルギー sulfonamide allergy in non hiv infected patients
4. 成人における難治性浮腫の治療 treatment of refractory edema in adults
5. 成人における浮腫に対する治療の一般原則 general principles of the treatment of edema in adults

English Journal

Diuretic Renal Scintigraphy in Patients with Sulfonamide Allergies: Possible Alternative Use of Ethacrynic Acid.

Nguyen BD1, Roarke MC2, Young JR3, Yang M2, Osborn HH2.
Journal of nuclear medicine technology.J Nucl Med Technol.2015 Dec;43(4):239-41. doi: 10.2967/jnmt.115.161331. Epub 2015 Oct 15.
Furosemide may trigger life-threatening sulfonamide cross-hypersensitivity reactions, posing a dilemma in patients who need diuretic renal scintigraphy.METHODS: We present our experience using ethacrynic acid as a nonsulfonamide alternative diuretic in 5 patients, with a discussion of the diuretic m
PMID 26471332

Efficacy of the cat deafening method: Co-administration of ethacrynic acid and kanamycin.

Jang JH1, Lee HS2, Oh SH3,4, Park MH2.
Acta oto-laryngologica.Acta Otolaryngol.2015 Nov 25:1-4. [Epub ahead of print]
OBJECTIVE: This study was designed to determine if hearing status monitoring during intravenous infusion of EA reduces individual variability and to evaluate the correlation between EA dose and Bwt.MATERIALS AND METHODS: Twenty-five cats with the mean age of 24 ± 3.7 weeks (range = 20.6-28.
PMID 26605909

Effects of Ethacrynic Acid Addition to Diet on Fitness and Development in the Psocid Liposcelis bostrychophila Badonnel.

Dou W1, Wu JJ1, Chen SC1, Wei DD1, Wang JJ2.
Environmental entomology.Environ Entomol.2015 Oct 16. pii: nvv157. [Epub ahead of print]
Fertility life table provides a comprehensive description of arthropod population dynamics by the estimation of parameters about arthropod population growth potential. It can also clarify the sublethal effects of chemicals on insects. Ethacrynic acid (EA), an inhibitor of glutathione S-transferases,
PMID 26475825

Japanese Journal

アポトーシス抑制タンパクPTD-FNKを用いた内耳タンパク治療

Otology Japan 22(5), 897-904, 2012-12-25
NAID 10031145248

Ototoxicity of cisplatin administered to guinea pigs via the round window membrane

Journal of toxicological sciences 37(4), 823-830, 2012-08-01
NAID 10030502549

Effects of Depletion of Glutathione on Abscisic Acid- and Methyl Jasmonate-Induced Stomatal Closure in <i>Arabidopsis thaliana</i>

Bioscience, Biotechnology, and Biochemistry 76(11), 2032-2037, 2012
NAID 130004137843

Related Pictures

Edecrin Sodium Intravenous, Edecrin Tablets (Merck), Drug Reference Encyclopedia Ethacrynic acid Russu - Diuretics Flashcards | Quizlet Medical Pharmacology: Uses of beta-adrenergic Receptor Blockers (Antagonists) in phospho(409/410)-TDP43 Antibody 22309-1-AP | Proteintech DailyMed - ETHACRYNIC ACID- ethacrynic acid tablet Chem Basis Diuretics 3 Flashcards | Quizlet

★リンクテーブル★

リンク元	「ethacrynate」「etacrynic acid」

「ethacrynate」

Etacrynic acid
Systematic (IUPAC) name
	[2,3-dichloro-4-(2-methylenebutanoyl)phenoxy]acetic acid
Clinical data
AHFS/Drugs.com	International Drug Names
MedlinePlus	a682857
Routes of; administration	Oral
Pharmacokinetic data
Protein binding	> 98%
Identifiers
CAS Registry Number	58-54-8
ATC code	C03CC01
PubChem	CID: 3278
IUPHAR/BPS	7179
DrugBank	DB00903
ChemSpider	3163
UNII	M5DP350VZV
KEGG	D00313
ChEBI	CHEBI:4876
ChEMBL	CHEMBL456
Chemical data
Formula	C13H12Cl2O4
Molecular mass	303.138 g/mol
	SMILES Clc1c(C(=O)\C(=C)CC)ccc(OCC(=O)O)c1Cl ;
	InChI InChI=1S/C13H12Cl2O4/c1-3-7(2)13(18)8-4-5-9(12(15)11(8)14)19-6-10(16)17/h4-5H,2-3,6H2,1H3,(H,16,17) ; Key:AVOLMBLBETYQHX-UHFFFAOYSA-N ;
(what is this?) (verify)