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a general term for female steroid sex hormones that are secreted by the ovary and responsible for typical female sexual characteristics (同)oestrogen

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エストロゲン(動物の雌を発情させる卵胞ホルモン)(《英》oestrogen)

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出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2015/12/29 08:41:03」(JST)

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Estrone sulfate, the primary active agent of esterified estrogen products.

Esterified estrogens (EEs) (brand names Amnestrogen, Estratab, Estratest, Evex, Femogen, Menest) are synthetic, plant-based estrogens that are manufactured from soybeans and yams.^[1]^[2] They are used in hormone replacement therapy for menopausal symptoms, female hypogonadism, ovariectomy, and primary ovarian failure and in the treatment of prostate cancer.^[3]

EEs consist primarily of sodium estrone sulfate and sodium equilin sulfate, and are very similar to conjugated equine estrogen (CEE) preparations such as Premarin.^[2]^[4]^[5] However, EEs and CEEs differ in the sources of their contents and in the percentages of their constituents; CEEs consist of approximately 53% sodium estrone sulfate and 25% sodium equilin sulfate, while EEs contain approximately 80% sodium estrone sulfate and 11% sodium equilin sulfate.^[4]^[6]^[3] EEs and CEEs have been found to produce similar serum levels of estrone and estradiol.^[7] One study found that the risk of venous thrombosis may be less with EEs relative to CEEs.^[6]^[2]

Estratest is a combination formulation of 1.25 mg EEs with 2.5 mg methyltestosterone.^[8]

References

^ Carl P. Weiner, MD; Kate Rope (2 April 2013). The Complete Guide to Medications During Pregnancy and Breastfeeding: Everything You Need to Know to Make the Best Choices for You and Your Baby. St. Martin's Press. pp. 179–. ISBN 978-0-312-67646-9.
^ ^a ^b ^c Smith, N. L.; Heckbert, S. R.; Lemaitre, R. N.; Reiner, A. P.; Lumley, T.; Rosendaal, F. R.; Psaty, B. M. (2006). "Conjugated Equine Estrogen, Esterified Estrogen, Prothrombotic Variants, and the Risk of Venous Thrombosis in Postmenopausal Women". Arteriosclerosis, Thrombosis, and Vascular Biology 26 (12): 2807–2812. doi:10.1161/01.ATV.0000245792.62517.3b. ISSN 1079-5642.
^ ^a ^b Manuchair Ebadi (31 October 2007). Desk Reference of Clinical Pharmacology, Second Edition. CRC Press. pp. 249–. ISBN 978-1-4200-4744-8.
^ ^a ^b Marc A. Fritz; Leon Speroff (28 March 2012). Clinical Gynecologic Endocrinology and Infertility. Lippincott Williams & Wilkins. pp. 752–. ISBN 978-1-4511-4847-3.
^ Tara Parker-Pope (9 January 2007). The Hormone Decision: Untangle the Controversy, Understand Your Options, Make Your Own Choices. Rodale. pp. 157–. ISBN 978-1-59486-927-3.
^ ^a ^b Smith, Nicholas L. (2004). "Esterified Estrogens and Conjugated Equine Estrogens and the Risk of Venous Thrombosis". JAMA 292 (13): 1581. doi:10.1001/jama.292.13.1581. ISSN 0098-7484.
^ Lemaitre, Rozenn N.; Weiss, Noel S.; Smith, Nicholas L.; Psaty, Bruce M.; Lumley, Thomas; Larson, Eric B.; Heckbert, Susan R. (2006). "Esterified Estrogen and Conjugated Equine Estrogen and the Risk of Incident Myocardial Infarction and Stroke". Archives of Internal Medicine 166 (4): 399. doi:10.1001/archinte.166.4.399. ISSN 0003-9926.
^ John E. Morley; Lucretia van den Berg (5 November 1999). Endocrinology of Aging. Springer Science & Business Media. pp. 172–. ISBN 978-1-59259-715-4.

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1. 閉経期のホルモン療法で用いる製剤 preparations for menopausal hormone therapy
2. 骨粗鬆症の予防および治療における閉経後のホルモン療法 postmenopausal hormone therapy in the prevention and treatment of osteoporosis
3. 閉経期のホルモン療法：利益とリスク menopausal hormone therapy benefits and risks
4. 閉経期のホルモン療法と心血管リスク menopausal hormone therapy and cardiovascular risk

English Journal

Formulations of hormone therapy and risk of Parkinson's disease.

Lundin JI1, Ton TG, LaCroix AZ, Longstreth WT, Franklin GM, Swanson PD, Smith-Weller T, Racette BA, Checkoway H.
Movement disorders : official journal of the Movement Disorder Society.Mov Disord.2014 Nov;29(13):1631-6. doi: 10.1002/mds.26037. Epub 2014 Sep 25.
Hormone therapy (HT) is a class of medications widely prescribed to women in the Western world. Evidence from animal models and in vitro studies suggests that estrogen may protect against nigrostriatal system injury and increase dopamine synthesis, metabolism, and transport. Existing epidemiologic r
PMID 25255692

Combined conjugated esterified estrogen plus methyltestosterone supplementation and risk of breast cancer in postmenopausal women.

Kabat GC1, Kamensky V2, Heo M2, Bea JW3, Hou L4, Lane DS5, Liu S6, Qi L7, Simon MS8, Wactawski-Wende J9, Rohan TE2.
Maturitas.Maturitas.2014 Sep;79(1):70-6. doi: 10.1016/j.maturitas.2014.06.006. Epub 2014 Jun 16.
OBJECTIVES: Testosterone supplementation is being prescribed increasingly to treat symptoms of hormone deficiency in pre- and postmenopausal women; however, studies of the association of testosterone therapy, alone or in combination with estrogen, with risk of breast cancer are limited. The current
PMID 25011395

Regulation of endothelial nitric oxide synthase and high-density lipoprotein quality by estradiol in cardiovascular pathology.

Kypreos KE1, Zafirovic S, Petropoulou PI, Bjelogrlic P, Resanovic I, Traish A, Isenovic ER.
Journal of cardiovascular pharmacology and therapeutics.J Cardiovasc Pharmacol Ther.2014 May;19(3):256-68. doi: 10.1177/1074248413513499. Epub 2014 Jan 12.
Estrogens have been recognized, in the last 3 decades, as important hormones in direct and indirect modulation of vascular health. In addition to their direct benefit on cardiovascular health, the presence of esterified estrogen in the lipid core of high-density lipoprotein (HDL) particles indirectl
PMID 24414281

Japanese Journal

Estrogen to progesterone ratio affects hormonal and lipid follicular fluid profiles in dairy cows

RENAVILLE BENEDICTE,COMIN ANTONELLA,FAZZINI UBERTO,MARCHINI ELENA,MAIERO STEFANO,MARCHI VITTORIO,PRANDI ALBERTO
Reproductive medicine and biology 6(1), 45-51, 2007-03-01
NAID 10018849670

Lowering Effect of an Isoflavone-Rich Fermented Soybean Extract on the Serum Cholesterol Concentrations in Female Rats, with or without Ovariectomy, but Not in Male Rats

Kishida Taro,Mizushige Takafumi,Nagamoto Manabu [他],OHTSU Yohhei,IZUMI Tohru,OBATA Akio,EBIHARA Kiyoshi
Bioscience, biotechnology, and biochemistry 70(7), 1547-1556, 2006-07-23
… Dietary FSBE increased the hepatic total and esterified cholesterol contents in the intact female rats, but decreased them in the OVX rats. … This hypocholesterolemic effect was not a simple estrogenic effect because it has appeared in some reports that estrogen administration decreased serum cholesterol both male and female rats. …
NAID 10018528598

シバヤギにおける絶食および再給餌期間中のGnRHパルスジェネレーター活動と血中代謝基質およびインスリン濃度変化との対応関係

松山秀一,大蔵聡,市丸徹 [他],SAKURAI Katsuyasu,TSUKAMURA Hiroko,MAEDA Kei-ichiro,OKAMURA Hiroaki
The Journal of reproduction and development 50(6), 697-704, 2004-12-01
… The time course of GnRH pulse generator activity and plasma concentrations of energy substrates and insulin were simultaneously observed in female goats during 4-day fasting and subsequent refeeding in the presence or absence of estrogen for a better understanding of the mechanism of energetic control of gonadotropin secretion in ruminants. … Plasma concentrations of non-esterified fatty acid and ketone body increased, while those of acetic acid and insulin decreased during fasting. …
NAID 10027324004