エポキシドヒドロラーゼ
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English Journal
- Characterization of an epoxide hydrolase from the Florida red tide dinoflagellate, Karenia brevis.
- Sun P1, Leeson C2, Zhi X2, Leng F3, Pierce RH4, Henry MS5, Rein KS6.
- Phytochemistry.Phytochemistry.2016 Feb;122:11-21. doi: 10.1016/j.phytochem.2015.11.002. Epub 2015 Nov 25.
- Epoxide hydrolases (EH, EC 3.3.2.3) have been proposed to be key enzymes in the biosynthesis of polyether (PE) ladder compounds such as the brevetoxins which are produced by the dinoflagellate Karenia brevis. These enzymes have the potential to catalyze kinetically disfavored endo-tet cyclization re
- PMID 26626160
- Highlight report: epoxide hydrolases-protection from reactive compounds and risk of cardiovascular disease.
- Godoy P1, Aranda M2.
- Archives of toxicology.Arch Toxicol.2015 Dec;89(12):2463-4. doi: 10.1007/s00204-015-1646-y.
- PMID 26597899
- Enzymology of Pyran Ring A Formation in Salinomycin Biosynthesis.
- Luhavaya H1, Dias MV2, Williams SR3, Hong H1, de Oliveira LG4, Leadlay PF5.
- Angewandte Chemie (International ed. in English).Angew Chem Int Ed Engl.2015 Nov 9;54(46):13622-5. doi: 10.1002/anie.201507090. Epub 2015 Sep 17.
- Tetrahydropyran rings are a common feature of complex polyketide natural products, but much remains to be learned about the enzymology of their formation. The enzyme SalBIII from the salinomycin biosynthetic pathway resembles other polyether epoxide hydrolases/cyclases of the MonB family, but SalBII
- PMID 26377145
Japanese Journal
- Biomimetic Total Synthesis of (−)-Neroplofurol and (+)-Ekeberin D4 Triggered by Hydrolysis of Terminal Epoxides
- Kodama Takeshi,Aoki Shingo,Matsuo Tomoki,Tachi Yoshimitsu,Nishikawa Keisuke,Morimoto Yoshiki
- Chemistry Letters 43(10), 1662-1664, 2014
- … To accumulate the chemical basis of epoxide-opening cascade biogenesis, chemical syntheses of sesqui- and triterpenoids were performed. … The biomimetic total syntheses of (−)-neroplofurol (1) and (+)-ekeberin D4 (2) were accomplished by protic acid-catalyzed hydrolysis of the terminal epoxide from nerolidol diepoxide 3 and squalene tetraepoxide 4 through single and double 5-exo cyclizations in intermediates 5 and 6, respectively. …
- NAID 130004693815
- Characterization of Juvenile Hormone Epoxide Hydrolase and Related Genes in the Larval Development of the Silkworm Bombyx mori
- Seino Atsushi,Ogura Takehiko,Tsubota Takuya [他],SHIMOMURA Masaru,NAKAKURA Takayo,TAN Anjiang,MITA Kazuei,SHINODA Tetsuro,NAKAGAWA Yoshiaki,SHIOTSUKI Takahiro
- Bioscience, biotechnology, and biochemistry 74(7), 1421-1429, 2010-07-23
- … Juvenile hormone epoxide hydrolases (JHEHs) are a family of enzymes that hydrolyze juvenile hormones (JHs). …
- NAID 10027557293
- Diversity and biocatalytic potential of epoxide hydrolases identified by genome analysis
Related Links
- Epoxide hydrolases (EH), enzymes present in all living organisms, transform epoxide-containing lipids to 1,2-diols by the addition of a molecule of water. Many of these oxygenated lipid substrates have potent biological activities: host ...
- Chemico-Biological Interactions 129 (2000) 41–59 Epoxide hydrolases: biochemistry and molecular biology Adrian J. Fretland, Curtis J. Omiecinski * Department of En6ironmental Health,of Washington, 4225 Roose6elt Way NE, c100 Seattle
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