WordNet

a tumor composed of granulation tissue resulting from injury or inflammation or infection

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1. 肺サルコイドーシスの臨床症状および診断 clinical manifestations and diagnosis of pulmonary sarcoidosis
2. 肝肉芽腫 hepatic granulomas
3. 肉芽腫性胃炎 granulomatous gastritis
4. 環状肉芽腫 granuloma annulare
5. Overview of the epidemiology, clinical presentation, diagnosis, and management of adult patients with bone metastasis

English Journal

Human polyethylene granuloma tissues inhibit bone healing in a novel xenograft animal model.

Esposito CI1, Oliver RA, Campbell PA, Yu Y, Walter WL, Walter WK, Walsh WR.Author information 1Surgical and Orthopaedic Research Laboratories, Clinical Sciences Building, Level 1, Prince of Wales Hospital, Randwick, NSW, 2031, Australia; Specialist Orthopaedic Group, Mater Clinic, Suite 1.08, 3-9 Gillies Street, Wollstonecraft, NSW, 2065, Australia.AbstractDuring revision of a conventional polyethylene joint replacement, surgeons usually remove the source of osteolysis (polyethylene) but cannot always remove all of the polyethylene granuloma tissues. We developed a human/rat xenograft model to investigate the effects of polyethylene granuloma tissues on bone healing. Human osteoarthritic and periprosthetic tissues collected during primary and revision hip arthroplasty surgeries were transplanted into the distal femora of athymic nude rats. After 3 weeks in vivo, there was a significant difference in the bone volume fraction (Vf ) between empty, primary, and revision defects (p = 0.02), with a lower Vf in defects with revision granuloma tissues compared to defects with primary osteoarthritic tissues. Polyethylene granuloma tissues in trabecular bone defects inhibited bone healing. Therefore, debridement around a metal-on-polyethylene hip replacement may shorten the time it takes to achieve secondary stability around a revision hip replacement. © 2014 Orthopaedic Research Society. Published by Wiley Periodicals, Inc. J Orthop Res 32:735-743, 2014.
Journal of orthopaedic research : official publication of the Orthopaedic Research Society.J Orthop Res.2014 Jun;32(6):735-43. doi: 10.1002/jor.22588. Epub 2014 Mar 12.
During revision of a conventional polyethylene joint replacement, surgeons usually remove the source of osteolysis (polyethylene) but cannot always remove all of the polyethylene granuloma tissues. We developed a human/rat xenograft model to investigate the effects of polyethylene granuloma tissues
PMID 24619566

Pulmonary functional and morphological damage after exposure to tripoli dust.

Machado MN1, Schmidt AC1, Saldiva PH2, Faffe DS1, Zin WA3.Author information 1Universidade Federal do Rio de Janeiro, Instituto de Biofísica Carlos Chagas Filho, Rio de Janeiro, Brazil.2Universidade de São Paulo, Faculdade de Medicina, São Paulo, Brazil.3Universidade Federal do Rio de Janeiro, Instituto de Biofísica Carlos Chagas Filho, Rio de Janeiro, Brazil. Electronic address: walter_zin@hotmail.com.AbstractTripoli is a microcrystalline siliceous rock used to polish metals and precious stones. Its inhalation has been associated with increased prevalence of breathing complaints and pneumoconiosis. However, its acute human exposure has not been so far studied. We aimed at evaluating the putative mechanical, morphological, biochemical and inflammatory lung damage in mice acutely exposed to Tripoli dust. BALB/c mice were randomly assigned to 2 groups: In control group (CTRL, n=6) animals received intratracheally (i.t.) 0.9% NaCl (50μl), while Tripoli group (TRIP, n=15) received 20mg of Tripoli powder diluted in 50μL of saline i.t. The experiments were done 15 days later. TRIP mice showed higher pulmonary mechanical impedance, polymorphonuclear cells, TNF-α, IL1-β and IL-6 than CTRL. TRIP presented granulomatous nodules containing collagenous fibers that occupied 35% of the lung tissue area. In conclusion, acute exposure to Tripoli dust triggered important lung damage in mice lungs that if found in human workers could trigger severe illness.
Respiratory physiology & neurobiology.Respir Physiol Neurobiol.2014 Jun 1;196:17-24. doi: 10.1016/j.resp.2014.02.007. Epub 2014 Feb 25.
Tripoli is a microcrystalline siliceous rock used to polish metals and precious stones. Its inhalation has been associated with increased prevalence of breathing complaints and pneumoconiosis. However, its acute human exposure has not been so far studied. We aimed at evaluating the putative mechanic
PMID 24582717

Characteristics and significance of colorectal cancer associated lymphoid reaction.

Väyrynen JP1, Sajanti SA, Klintrup K, Mäkelä J, Herzig KH, Karttunen TJ, Tuomisto A, Mäkinen MJ.Author information 1Department of Pathology, University of Oulu, Finland; Oulu University Hospital Oulu, Finland, and Medical Research Center Oulu, Finland.AbstractA subset of colorectal cancers (CRCs) exhibits so-called Crohn's like lymphoid reaction (CLR), an inflammatory reaction pattern that consists of numerous transmural lymphoid aggregates. However, the composition of these aggregates, their biological mechanisms and their prognostic significance are not well-defined. We analyzed two CRC cohorts (418 and 149 patients) and determined clinicopathological features including survival. A new method for evaluating CLR based on counting the areal density of the lymphoid follicles (CLR density) was adopted. Immune cell densities at intratumoral and peritumoral regions, as well as the composition of the lymphoid follicles, were studied by immunohistochemistry. We found that CLR comprised of lymphoid aggregates with no evidence of granuloma formation. High CLR density associated with lower tumor stage, lack of preoperative radiotherapy or chemoradiotherapy and deficient mismatch repair enzyme expression. CLR density had positive correlations with peritumoral and intratumoral densities of CD83(+) mature dendritic cells and T cells. High CLR density associated with better survival and had prognostic value that was independent of stage, Klintrup-Mäkinen score for peritumoral inflammation and the numbers of tumor infiltrating T cells. CLR density evaluation had excellent intraobserver and interobserver agreement. In conclusion, the results suggest that CLR contributes to the adaptive antitumor immunity. Quantitative evaluation of CLR density is a relevant prognostic indicator in CRC.
International journal of cancer. Journal international du cancer.Int J Cancer.2014 May 1;134(9):2126-35. doi: 10.1002/ijc.28533. Epub 2013 Oct 24.
A subset of colorectal cancers (CRCs) exhibits so-called Crohn's like lymphoid reaction (CLR), an inflammatory reaction pattern that consists of numerous transmural lymphoid aggregates. However, the composition of these aggregates, their biological mechanisms and their prognostic significance are no
PMID 24154855