English Journal

4-Amino-3(2H)-pyridazinones bearing arylpiperazinylalkyl groups and related compounds: synthesis and antinociceptive activity.

Piaz VD, Vergelli C, Giovannoni MP, Scheideler MA, Petrone G, Zaratin P.SourceDipartimento di Scienze Farmaceutiche, Università di Firenze, via G. Capponi 9, 50121 Firenze, Italy. vittorio.dalpiaz@unifi.it
Farmaco (Società chimica italiana : 1989).Farmaco.2003 Nov;58(11):1063-71.
A series of 4-amino-3(2H)-pyridazinones substituted at position 2 with arylpiperazinylalkyl groups and analogues were synthesized and their antinociceptive effect was evaluated in the mouse abdominal constriction model. Preliminary SARs studies were performed. Several of the novel compounds dosed at
PMID 14572856

[Studies on pyridazinone derivatives. XVI. Analgesic-antiinflammatory activities of 3(2H)-pyridazinone derivatives].

Takaya M, Sato M.SourceHamari Chemical Co., Ltd., Osaka, Japan.
Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan.Yakugaku Zasshi.1994 Feb;114(2):94-110.
In order to examine analgesic and antiinflammatory activities of the position isomers of 4-ethoxy-2-methyl-5-morpholino-3(2H)-pyridazinone (1, emorfazone), an analgesic-antiinflammatory drug, 5-ethoxy-2-methyl-4-morpholino-3(2H)-pyridazinone (2), 6-ethoxy-2-methyl-4-morpholino-3(2H)-pyridazinone (3)
PMID 8169774

Japanese Journal

高谷昌弘,佐藤誠
藥學雜誌 114(2), 94-110, 1994-02-25
… In order to examine analgesic and antiinflammatory activities of the position isomers of 4-ethoxy-2-methyl-5-morpholino-3 (2H)-pyridazinone (1,emorfazone), an analgesic-antiinflammatory drug, 5-ethoxy-2-methyl-4-morpholino-3 (2H)-pyridazinone (2), 6-ethoxy-2-methyl-4-morpholino-3 (2H)-pyridazinone (3) and 6-ethoxy-2-methyl-5-morpholino-3 (2H)-pyridazinone (4) were prepared. …
NAID 110003649471

<Abstract of annual report>Photochemical Oxidation of 4-Ethoxy-2-methyl-5-morpholino-3(2H)-pyridazinone (Emorfazone) by Pyrimido[5,4-g]pteridine 5-Oxide.