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the base of the natural system of logarithms; approximately equal to 2.718282...

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出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2015/10/01 09:02:43」(JST)

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Eukaryotic elongation factor 2 is a protein that in humans is encoded by the EEF2 gene.^[1]^[2]^[3]

This gene encodes a member of the GTP-binding translation elongation factor family. This protein is an essential factor for protein synthesis. It promotes the GTP-dependent translocation of the ribosome. This protein is completely inactivated by EF-2 kinase phosphorylation.^[3]

It is the target of diphtheria toxin and exotoxin A.^[4]

References

^ Rapp G, Klaudiny J, Hagendorff G, Luck MR, Scheit KH (Mar 1990). "Complete sequence of the coding region of human elongation factor 2 (EF-2) by enzymatic amplification of cDNA from human ovarian granulosa cells". Biol Chem Hoppe Seyler 370 (10): 1071–5. doi:10.1515/bchm3.1989.370.2.1071. PMID 2610926.
^ Kaneda Y, Yoshida MC, Kohno K, Uchida T, Okada Y (Jul 1984). "Chromosomal assignment of the gene for human elongation factor 2". Proc Natl Acad Sci U S A 81 (10): 3158–62. doi:10.1073/pnas.81.10.3158. PMC 345240. PMID 6427766.
^ ^a ^b "Entrez Gene: EEF2 eukaryotic translation elongation factor 2".
^ Jørgensen R, Merrill AR, Andersen GR (February 2006). "The life and death of translation elongation factor 2". Biochem. Soc. Trans. 34 (Pt 1): 1–6. doi:10.1042/BST20060001. PMID 16246167.

External links

Peptide Elongation Factor 2 at the US National Library of Medicine Medical Subject Headings (MeSH)

English Journal

Characterization of anti-P monoclonal antibodies directed against the ribosomal protein-RNA complex antigen and produced using Murphy Roths large autoimmune-prone mice.

Sato H1, Onozuka M, Hagiya A, Hoshino S, Narita I, Uchiumi T.
Clinical and experimental immunology.Clin Exp Immunol.2015 Feb;179(2):236-44. doi: 10.1111/cei.12460.
Autoantibodies, including anti-ribosomal P proteins (anti-P), are thought to be produced by an antigen-driven immune response in systemic lupus erythematosus (SLE). To test this hypothesis, we reconstituted the ribosomal antigenic complex in vitro using human P0, phosphorylated P1 and P2 and a 28S r
PMID 25255895

eEF-2 Phosphorylation Down-Regulates P-Glycoprotein Over-Expression in Rat Brain Microvessel Endothelial Cells.

Tang XH1, Wu XY1, Xu L1, Fang YX1, Wang P1, Zhu GX1, Hong Z1.
PloS one.PLoS One.2015 May 11;10(5):e0125389. doi: 10.1371/journal.pone.0125389. eCollection 2015.
OBJECTIVE: We investigated whether glutamate, NMDA receptors, and eukaryote elongation factor-2 kinase (eEF-2K)/eEF-2 regulate P-glycoprotein expression, and the effects of the eEF-2K inhibitor NH125 on the expression of P-glycoprotein in rat brain microvessel endothelial cells (RBMECs).METHODS: Cor
PMID 25962137

Reversible covalent inhibition of eEF-2K by carbonitriles.

Devkota AK1, Edupuganti R, Yan C, Shi Y, Jose J, Wang Q, Kaoud TS, Cho EJ, Ren P, Dalby KN.
Chembiochem : a European journal of chemical biology.Chembiochem.2014 Nov 3;15(16):2435-42. doi: 10.1002/cbic.201402321. Epub 2014 Sep 15.
eEF-2K is a potential target for treating cancer. However, potent specific inhibitors for this enzyme are lacking. Previously, we identified 2,6-diamino-4-(2-fluorophenyl)-4H-thiopyran-3,5-dicarbonitrile (DFTD) as an inhibitor of eEF-2K. Here we describe its mechanism of action against eEF-2K, on th
PMID 25224652

Japanese Journal

『カルモジュリンと高血圧症メカニズムの新展開』　高血圧症の病態を制御する新たなカルモジュリン関連タンパク質の血管系における機能

臼井達哉,岡田宗善,原幸男 [他],山脇英之
日本薬理学雑誌 141(2), 85-89, 2013
… Ca2+結合タンパク質であるカルモジュリン（CaM）はCaM依存性（関連）タンパク質の機能調節を介して筋収縮，免疫応答，代謝，神経成長といった様々な細胞機能に影響を与える．最近，CaMおよびCaM依存性プロテインキナーゼ（CaMK）IIが心血管疾患の病態進展に関わるという報告がなされた．高血圧症の病態ではTNF-<I>α</I>やIL-6といった炎症性サイトカインの血中濃度が上昇し，活性酸素種（reactive oxygen …
NAID 130003362534

Comparative Study of the in Vitro Protective Effects of Several Antioxidants on Elongation Factor 2 under Oxidative Stress Conditions

, , [他],
Bioscience, biotechnology, and biochemistry 74(7), 1373-1379, 2010-07-23
… Previous reports from our laboratory have indicated that the elongation step is specially affected by aging as a consequence of alterations in elongation factor-2 (eEF-2). … the effectiveness of several individual nutritional antioxidants in protecting the levels of hepatic eEF-2 subjected to oxidative stress induced by cumene hydroperoxide. …
NAID 10027557055

Trp^<221> is involved in the protective effect of elongation factor eEF-2 on te ricin/α-sarcin site of the ribosome

GUILLOT D.
J. Biol. Chem. 268, 26082-26084, 1993
NAID 80007381477

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リンク元

「EF-2」

Eukaryotic translation elongation factor 2
Available structures
PDB	Ortholog search: PDBe, RCSB
List of PDB id codes
	4V6X
Identifiers
Symbols	EEF2 ; EEF-2; EF-2; EF2; SCA26
External IDs	OMIM: 130610 MGI: 95288 HomoloGene: 134867 ChEMBL: 1795108 GeneCards: EEF2 Gene
Gene ontology
Molecular function	• translation elongation factor activity; • GTPase activity; • protein binding; • GTP binding; • protein kinase binding; • poly(A) RNA binding;
Cellular component	• nucleus; • cytoplasm; • cytosol; • polysome; • plasma membrane; • membrane; • aggresome; • ribonucleoprotein complex; • extracellular exosome;
Biological process	• hematopoietic progenitor cell differentiation; • translation; • translational elongation; • gene expression; • peptidyl-diphthamide biosynthetic process from peptidyl-histidine; • post-translational protein modification; • cellular protein metabolic process; • positive regulation of translation;
	Sources: Amigo / QuickGO
RNA expression pattern
	More reference expression data
Orthologs
	v; t; e;

　　[★]

同: eEF-2

同: eEF-2

[pmid2610926-1] Rapp G, Klaudiny J, Hagendorff G, Luck MR, Scheit KH (Mar 1990). "Complete sequence of the coding region of human elongation factor 2 (EF-2) by enzymatic amplification of cDNA from human ovarian granulosa cells". Biol Chem Hoppe Seyler 370 (10): 1071–5. doi:10.1515/bchm3.1989.370.2.1071. PMID 2610926.

[pmid6427766-2] Kaneda Y, Yoshida MC, Kohno K, Uchida T, Okada Y (Jul 1984). "Chromosomal assignment of the gene for human elongation factor 2". Proc Natl Acad Sci U S A 81 (10): 3158–62. doi:10.1073/pnas.81.10.3158. PMC 345240. PMID 6427766.

[entrez-3] "Entrez Gene: EEF2 eukaryotic translation elongation factor 2".

[pmid16246167-4] Jørgensen R, Merrill AR, Andersen GR (February 2006). "The life and death of translation elongation factor 2". Biochem. Soc. Trans. 34 (Pt 1): 1–6. doi:10.1042/BST20060001. PMID 16246167.

匿名

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案内

案内

eEF-2