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1. 薬物アレルギー患者へのアプローチ an approach to the patient with drug allergy
2. 抗マラリア剤：概要 antimalarial drugs an overview
3. 成人における薬物中毒への一般的アプローチ general approach to drug poisoning in adults
4. リウマチ性疾患における免疫抑制剤および疾患修飾剤の使用の概要 overview of the use of immunosuppressive and disease modifying drugs in the rheumatic diseases
5. 慢性疼痛の治療の概要 overview of the treatment of chronic pain

Design, synthesis and biological evaluation of novel HSP70 inhibitors: N, N'-disubstituted thiourea derivatives.

Zeng YQ1, Cao RY2, Yang JL3, Li XZ3, Li S3, Zhong W4.
European journal of medicinal chemistry.Eur J Med Chem.2016 Aug 25;119:83-95. doi: 10.1016/j.ejmech.2016.04.042. Epub 2016 Apr 20.
As novel heat shock protein 70 (HSP70) inhibitors, N, N'-disubstituted thiourea derivatives were designed and synthesized based on the X-ray structure of the ATPase domain (nucleotide binding domain, NBD). An ATPase activity inhibition assay revealed that these compounds effectively inhibited HSP70
PMID 27155465

Levamisole-adulterated cocaine: Two fatal case reports and evaluation of possible cocaine toxicity potentiation.

Indorato F1, Romano G2, Barbera N2.
Forensic science international.Forensic Sci Int.2016 Aug;265:103-6. doi: 10.1016/j.forsciint.2016.01.005. Epub 2016 Jan 14.
Levamisole has been identified as a cocaine adulterant in the United States since 2002. Although there is a variation in the percentage of levamisole in cocaine samples between European countries, measurement of levamisole in human samples of cocaine users has become increasingly important. To our b
PMID 26866560

Bis(propyl)-cognitin Prevents β-amyloid-induced Memory Deficits as Well as Synaptic Formation and Plasticity Impairments via the Activation of PI3-K Pathway.

Jiang L1, Huang M1,2, Xu S3, Wang Y1, An P1, Feng C1, Chen X1, Wei X1, Han Y4, Wang Q5.
Molecular neurobiology.Mol Neurobiol.2016 Aug;53(6):3832-41. doi: 10.1007/s12035-015-9317-9. Epub 2015 Jul 10.
Bis(propyl)-cognitin (B3C), derived from tacrine linked with three methylene (-CH2-) groups, is a dimerized molecule interacting multiple targets. During the past several years, it has been reported as a promising therapeutic drug for Alzheimer's disease (AD) and other neurodegenerative disorders. H
PMID 26160762