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1. 心不全における骨格筋機能低下および運動耐容能低下 skeletal muscle dysfunction and exercise intolerance in heart failure
2. ガラクトース血症の臨床的特徴および診断 clinical features and diagnosis of galactosemia
3. 先天性および後天性血小板機能障害 congenital and acquired disorders of platelet function
4. ミトコンドリア細胞症における腎病変 renal involvement in the mitochondrial cytopathies
5. 高IgD症候群：病態生理 hyperimmunoglobulin d syndrome pathophysiology

English Journal

N-glycosylation in the thermoacidophilic archaeon Sulfolobus acidocaldarius involves a short dolichol pyrophosphate carrier.

Guan Z1, Delago A2, Nußbaum P3, Meyer B3, Albers SV3, Eichler J4.
FEBS letters.FEBS Lett.2016 Sep;590(18):3168-78. doi: 10.1002/1873-3468.12341. Epub 2016 Sep 12.
N-glycosylation is a post-translational modification that occurs across evolution. In the thermoacidophilic archaea Sulfolobus acidocaldarius, glycoproteins are modified by an N-linked tribranched hexasaccharide reminiscent of the N-glycans assembled in Eukarya. Previously, hexose-bearing dolichol p
PMID 27490243

Comparative Analysis of Archaeal Lipid-linked Oligosaccharides That Serve as Oligosaccharide Donors for Asn Glycosylation.

Taguchi Y1, Fujinami D1, Kohda D2.
The Journal of biological chemistry.J Biol Chem.2016 May 20;291(21):11042-54. doi: 10.1074/jbc.M115.713156. Epub 2016 Mar 25.
The glycosylation of asparagine residues is the predominant protein modification in all three domains of life. An oligosaccharide chain is preassembled on a lipid-phospho carrier and transferred onto asparagine residues by the action of a membrane-bound enzyme, oligosaccharyltransferase. The oligosa
PMID 27015803

N-Linked Glycans Are Assembled on Highly Reduced Dolichol Phosphate Carriers in the Hyperthermophilic Archaea Pyrococcus furiosus.

Chang MM1, Imperiali B1, Eichler J2, Guan Z3.
PloS one.PLoS One.2015 Jun 22;10(6):e0130482. doi: 10.1371/journal.pone.0130482. eCollection 2015.
In all three domains of life, N-glycosylation begins with the assembly of glycans on phosphorylated polyisoprenoid carriers. Like eukaryotes, archaea also utilize phosphorylated dolichol for this role, yet whereas the assembled oligosaccharide is transferred to target proteins from dolichol pyrophos
PMID 26098850

Study on the Biosynthesis of Dolichol in Yeast. Recognition of the Prenyl Chain Length in Polyprenol Reduction.

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The Journal of Biochemistry 129(2), 297-302, 2001
… We synthesized three water-soluble biotin-tagged compounds with different prenyl chain lengths, biotinylated farnesal (BF), biotinylated C55 polyprenal (BP55), and biotinylated C80-polyprenol (BP80), and examined their effects on in vitro dolichol synthesis from farnesyl diphosphate. …
NAID 130003534084

Subcellular Fractionation of Polyprenyl Diphosphate Synthase Activities Responsible for the Syntheses of Polyprenols and Dolichols in Spinach Leaves

Characterization of dehydrodolichyl diphosphate synthase of Arabidopsis thaliana, a key enzyme in dolichol biosynthesis