WordNet
- characterized by painstaking care and detailed examination; "a minute inspection of the grounds"; "a narrow scrutiny"; "an exact and minute report" (同)narrow
- a unit of angular distance equal to a 60th of a degree (同)arcminute, minute of arc
- a unit of time equal to 60 seconds or 1/60th of an hour; "he ran a 4 minute mile" (同)min
- a short note; "the secretary keeps the minutes of the meeting"
- a loss (or serious disruption) of organization in some system; "a disintegration of personality"
- a written account of what transpired at a meeting (同)proceedings, transactions
- the 17th letter of the Hebrew alphabet
PrepTutorEJDIC
- (時間の単位の)『分』(1/60時間;《略》『m.,min.』) / (角度の単位の)分(1/60度;記号は'で,数字の後に付ける) / 〈U〉《しばしばa ~》《話》『瞬間』,ちょっとの間(moment) / (また『minute book』)《複数形で》(会議の)景事録
- 『ごく小さい』,微細な / 『精密な』,詳しい / ささいな,取るに足りない
- …『につき』,…ごとに / 《文》…によって,…で,…を通じて / 《しばしば『as per』…で》…によって示された通りに,…に従って
- 分解,崩壊 / (放射性元素の)崩壊 / (岩石などの)風化作用
UpToDate Contents
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- 1. Mechanisms, causes, and effects of hypercapnia
- 2. 心不全における運動耐用能およびVO2 exercise capacity and vo2 in heart failure
- 3. 成人における肺機能検査の概要 overview of pulmonary function testing in adults
- 4. 成人におけるごく少量の直腸からの出血へのアプローチ approach to minimal bright red bleeding per rectum in adults
- 5. 妊娠中の心肺停止 cardiopulmonary arrest in pregnancy
English Journal
- A Dose-Response Study of Arsenic Exposure and Global Methylation of Peripheral Blood Mononuclear Cell DNA in Bangladeshi Adults.
- Niedzwiecki MM, Hall MN, Liu X, Oka J, Harper KN, Slavkovich V, Ilievski V, Levy D, van Geen A, Mey JL, Alam S, Siddique AB, Parvez F, Graziano JH, Gamble MV.Author information Department of Environmental Health Sciences, Mailman School of Public Health, Columbia University, New York, New York, USA.AbstractBackground: Several studies employing cell culture and animal models have suggested that arsenic (As) exposure induces global DNA hypomethylation. However, As has been associated with global DNA hypermethylation in human study populations. We hypothesized that this discrepancy may reflect a nonlinear relationship between As dose and DNA methylation.Objective: The objective of this study was to examine the dose-response relationship between As and global methylation of peripheral blood mononuclear cell (PBMC) DNA in apparently healthy Bangladeshi adults chronically exposed to a wide range of As concentrations in drinking water.Methods: Global PBMC DNA methylation, plasma folate, blood S-adenosylmethionine (SAM), and concentrations of As in drinking water, blood, and urine were measured in 320 adults. DNA methylation was measured using the [3H]-methyl incorporation assay, which provides disintegration-per-minute (DPM) values that are negatively associated with global DNA methylation.Results: Water, blood, and urinary As were positively correlated with global PBMC DNA methylation (p < 0.05). In multivariable-adjusted models, 1-μg/L increases in water and urinary As were associated with 27.6-unit (95% CI: 6.3, 49.0) and 22.1-unit (95% CI: 0.5, 43.8) decreases in DPM per microgram DNA, respectively. Categorical models indicated that estimated mean levels of PBMC DNA methylation were highest in participants with the highest As exposures.Conclusions: These results suggest that As is positively associated with global methylation of PBMC DNA over a wide range of drinking water As concentrations. Further research is necessary to elucidate underlying mechanisms and physiologic implications.Citation: Niedzwiecki MM, Hall MN, Liu X, Oka J, Harper KN, Slavkovich V, Ilievski V, Levy D, van Geen A, Mey JL, Alam S, Siddique AB, Parvez F, Graziano JH, Gamble MV. 2013. A dose-response study of arsenic exposure and global methylation of peripheral blood mononuclear cell DNA in Bangladeshi adults. Environ Health Perspect 121:1306-1312; http://dx.doi.org/10.1289/ehp.1206421.
- Environmental health perspectives.Environ Health Perspect.2013 11-12;121(11-12):1306-1312. Epub 2013 Sep 4.
- Background: Several studies employing cell culture and animal models have suggested that arsenic (As) exposure induces global DNA hypomethylation. However, As has been associated with global DNA hypermethylation in human study populations. We hypothesized that this discrepancy may reflect a nonlinea
- PMID 24013868
- Presynaptic TRPV1 vanilloid receptor function is age- but not CB1 cannabinoid receptor-dependent in the rodent forebrain.
- Köles L, Garção P, Zádori ZS, Ferreira SG, Pinheiro BS, da Silva-Santos CS, Ledent C, Köfalvi A.Author information Department of Pharmacology and Pharmacotherapy, Faculty of Medicine, Semmelweis University, Nagyvárad tér 4, 1089 Budapest, Hungary.AbstractNeocortical and striatal TRPV1 (vanilloid or capsaicin) receptors (TRPV1Rs) are excitatory ligand-gated ion channels, and are implicated in psychiatric disorders. However, the purported presynaptic neuromodulator role of TRPV1Rs in glutamatergic, serotonergic or dopaminergic terminals of the rodent forebrain remains little understood. With the help of patch-clamp electrophysiology and neurochemical approaches, we mapped the age-dependence of presynaptic TRPV1R function, and furthermore, we aimed at exploring whether the presence of CB1 cannabinoid receptors (CB1Rs) influences the function of the TRPV1Rs, as both receptor types share endogenous ligands. We found that the major factor which affects presynaptic TRPV1R function is age: by post-natal day 13, the amplitude of capsaicin-induced release of dopamine and glutamate is halved in the rat striatum, and two weeks later, capsaicin already loses its effect. However, TRPV1R receptor function is not enhanced by chemical or genetic ablation of the CB1Rs in dopaminergic, glutamatergic and serotonergic terminals of the mouse brain. Altogether, our data indicate a possible neurodevelopmental role for presynaptic TRPV1Rs in the rodent brain, but we found no cross-talk between TRPV1Rs and CB1Rs in the same nerve terminal.
- Brain research bulletin.Brain Res Bull.2013 Aug;97:126-35. doi: 10.1016/j.brainresbull.2013.06.007. Epub 2013 Jul 4.
- Neocortical and striatal TRPV1 (vanilloid or capsaicin) receptors (TRPV1Rs) are excitatory ligand-gated ion channels, and are implicated in psychiatric disorders. However, the purported presynaptic neuromodulator role of TRPV1Rs in glutamatergic, serotonergic or dopaminergic terminals of the rodent
- PMID 23831917
- Overcoming bioanalytical challenges in an Onglyza(®) intravenous [(14)C]microdose absolute bioavailability study with accelerator MS.
- Xu XS, Dueker SR, Christopher LJ, Lohstroh PN, Keung CF, Cao KK, Bonacorsi SJ, Cojocaru L, Shen JX, Humphreys WG, Stouffer B, Arnold ME.Author information Research & Development, Bristol-Myers Squibb, Princeton, NJ 08543, USA. xiaohui.xu@bms.comAbstractBACKGROUND: An absolute bioavailability study that utilized an intravenous [(14)C]microdose was conducted for saxagliptin (Onglyza(®)), a marketed drug product for the treatment of Type 2 diabetes mellitus. Concentrations of [(14)C]saxagliptin were determined by accelerator MS (AMS) after protein precipitation, chromatographic separation by UPLC and analyte fraction collection. A series of investigative experiments were conducted to maximize the release of the drug from high-affinity receptors and nonspecific adsorption, and to determine a suitable quantitation range.
- Bioanalysis.Bioanalysis.2012 Aug;4(15):1855-70. doi: 10.4155/bio.12.171.
- BACKGROUND: An absolute bioavailability study that utilized an intravenous [(14)C]microdose was conducted for saxagliptin (Onglyza(®)), a marketed drug product for the treatment of Type 2 diabetes mellitus. Concentrations of [(14)C]saxagliptin were determined by accelerator MS (AMS) after protein p
- PMID 22943617
Japanese Journal
- 寒冷地における生物脱臭材の適合性
- 市川 忠雄,市川 意子,福森 功,野附 巌
- 日本家畜管理研究会誌 28(3), 97-104, 1993-02-10
- 脱臭に関する微生物の最適温度は20〜30℃前後で、10℃以下の環境条件になると微生物の活性とくに硝化能力が低下し、これに伴って脱臭能力が減退すると考えられている。最近開発されたロックウール脱臭材を用いた脱臭装置は、脱臭能力や経済性で優れていることが既に立証されているが、寒冷地域における冬期間の性能については明らかにされていない。そこで、冬季の外気温が零下15℃前後に低下する青森県十和田市にある北里 …
- NAID 110003852927
- 白色プリマスロック矮性鶏下垂体前葉のタンパク合成の特徴
- 星野 貞夫,和田 健一
- 日本家禽学会誌 14(4), 185-195, 1977
- 白色プリマスロックの正常, 矮性鶏の雌雄について胚15, 18日齢, 孵化後3, 6, 13, 20週齢および成鶏時に屠殺, 下垂体前葉をとり出し, 標識アミノ酸とともにin vitro で培養し, GH, PLなどの合成, 分泌および下垂体中の含量をディスク電気泳動法を用いて測定, 比較した。各ホルモン, タンパクの合成は標識アミノ酸の各タンパクへのくみこみ速度 (DPM/100g体重/2時間) …
- NAID 130003622000
- 脳腫瘍の非手術的療法 microwave 照射による効果
- 安井 信之
- 関西医科大学雑誌 26(3), 337-351, 1974
- … In irradiated group, the percent ratio of disintegration per minute per mg weight of the irradiated tumor versus that of the non-treated was 48.1±18.1, i. …
- NAID 130004625308
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Related Pictures
★リンクテーブル★
| リンク元 | 「dpm」「d.p.m.」「壊変毎分」 |
| 関連記事 | 「minute」「per」「disintegration」「PER」「pe」 |
「dpm」
「d.p.m.」
「壊変毎分」
「minute」
- 発音記号が違う
- n.
- 分。一瞬、瞬間。(the ～)現在、今。1分間に進む距離
- 覚え書き、控え。(文書の)簡単な草案。(pl.)議事録
- adj.
- 急ごしらえの
- vt.
- adj.
- 微少な、微細な。詳細な、精密な、細心な。些細な、取るに足らぬ
「per」
- prep
- (商)～につき/ごとに
- ～で、～によって。～に託して
- ～によれば
- adv.
- 1個につき、各。
「disintegration」
- n.
「PER」
「pe」
- n.
- 体育。ペルーのドメイン名