WordNet

in disarray; extremely disorderly; "her clothing was disheveled"; "powder-smeared and frowzled"; "a rumpled unmade bed"; "a bed with tousled sheets"; "his brown hair was tousled, thick, and curly"- Al Spiers (同)dishevelled, frowzled, rumpled, tousled
not properly maintained or cared for; "an unkempt garden"; "native vistas and unkempt rambling paths"; "an ukempt appearance"
not neatly combed; "wild unkempt hair"

PrepTutorEJDIC

(髪が)くしを入れてない,もどゃもどゃの / (服装・外見などが)だらしがない
(服装・髪などが)乱れた,ぼさぼさの
〈髪など〉‘を'ぼさぼさに垂らす;〈着物など〉‘を'だラント着る

Wikipedia preview

出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2015/06/02 17:00:35」(JST)

wiki en

Dishevelled (Dsh) is a family of proteins involved in canonical and non-canonical Wnt signalling pathways. Dsh is a cytoplasmic phosphoprotein that acts directly downstream of frizzled receptors.^[1] It takes its name from its initial discovery in flies, where a mutation in the dishevelled gene was observed to cause improper orientation of body and wing hairs.^[2]

Dishevelled plays important roles in both the embryo and the adult, ranging from cellular differentiation and cell polarity to social behavior.^[2]

Members

There are three human genes that encode for the dishevelled proteins:^[3]

DVL1
DVL2
DVL3

Overview of signal transduction pathways involved in apoptosis.

Example

Alignment of dishevelled-specific domain

References

^ Penton A, Wodarz A, Nusse R (June 2002). "A mutational analysis of dishevelled in Drosophila defines novel domains in the dishevelled protein as well as novel suppressing alleles of axin". Genetics 161 (2): 747–62. PMC 1462152. PMID 12072470.
^ ^a ^b Wallingford JB, Habas R (October 2005). "The developmental biology of Dishevelled: an enigmatic protein governing cell fate and cell polarity". Development 132 (20): 4421–36. doi:10.1242/dev.02068. PMID 16192308. |accessdate= requires |url= (help)
^ Lee YN, Gao Y, Wang HY (February 2008). "Differential mediation of the Wnt canonical pathway by mammalian Dishevelleds-1, -2, and -3". Cell. Signal. 20 (2): 443–52. doi:10.1016/j.cellsig.2007.11.005. PMC 2233603. PMID 18093802.

External links

dishevelled proteins at the US National Library of Medicine Medical Subject Headings (MeSH)

This protein-related article is a stub. You can help Wikipedia by expanding it.

UpToDate Contents

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1. 小児における身体的診察：一般原則および標準的な測定 the pediatric physical examination general principles and standard measurements
2. ガンマヒドロキシブチレート（GHB）中毒 gamma hydroxybutyrate ghb intoxication
3. 覚せい剤中毒 methamphetamine intoxication

English Journal

Periodontal disease epidemiology - learned and unlearned?

Baelum V, López R.AbstractThe notion of periodontal disease being the major cause of tooth loss among adults was rooted in the focal infection paradigm that dominated the first half of the 20th century. This paradigm was established largely by personal opinions, and it was not until the development of periodontal indices in the mid-1950s that periodontal epidemiology gained momentum. Unfortunately, the indices used suffered from a number of flaws, whereby the interpretation of the research results took the form of circular reasoning. It was under this paradigm that therapeutic and preventive intervention for periodontal diseases became entirely devoted to oral hygiene, as poor oral hygiene and older age were understood to explain nearly all the variation in disease occurrence. In the early 1980s, studies appeared that contradicted the concepts of poor oral hygiene as the inevitable trigger of periodontitis and of linear and ubiquitous periodontitis progression, whereby periodontal epidemiology was led into a relatively short-lived high-risk era. At this time, it became evident that old scourges continue to haunt periodontology: the inability to agree in operational clinical criteria for a periodontitis diagnosis and the inability to devise both a meaningful and a useful classification of periodontal diseases based on nominalist principles. The meager outcome of the high-risk era led researchers to resurrect the focal infection paradigm, which is now dressed up as periodontal medicine. Unfortunately, these developments have left the core of periodontology somewhat disheveled and deserted.
Periodontology 2000.Periodontol 2000.2013 Jun;62(1):37-58. doi: 10.1111/j.1600-0757.2012.00449.x.
The notion of periodontal disease being the major cause of tooth loss among adults was rooted in the focal infection paradigm that dominated the first half of the 20th century. This paradigm was established largely by personal opinions, and it was not until the development of periodontal indices in
PMID 23574463

Role of PI3K-AKT-mTOR and Wnt Signaling Pathways in Transition of G1-S Phase of Cell Cycle in Cancer Cells.

Vadlakonda L, Pasupuleti M, Pallu R.SourceDepartment of Zoology, Kakatiya University Warangal, Andhra Pradesh, India.
Frontiers in oncology.Front Oncol.2013 Apr 12;3:85. doi: 10.3389/fonc.2013.00085. Print 2013.
The PI3K-Akt pathway together with one of its downstream targets, the mechanistic target of rapamycin (mTOR; also known as the mammalian target of rapamycin) is a highly deregulated pathway in cancers. mTOR exists in two complexes, mTORC1 and mTORC2. Akt phosphorylated at T308 inhibits TSC1/2 comple
PMID 23596569

Pertussis toxin-sensitive heterotrimeric G(αi/o) proteins mediate WNT/β-catenin and WNT/ERK1/2 signaling in mouse primary microglia stimulated with purified WNT-3A.

Halleskog C, Schulte G.SourceDept. Physiology & Pharmacology, Sec Receptor Biology & Signaling, Karolinska Institutet, S-17177 Stockholm, Sweden.
Cellular signalling.Cell Signal.2013 Apr;25(4):822-8. doi: 10.1016/j.cellsig.2012.12.006. Epub 2012 Dec 22.
WNT-3A is a secreted lipoglycoprotein that engages Class Frizzled receptors and LDL receptor related protein 5/6 (LRP5/6) for cellular communication. Generally, WNT-3A mediates WNT/β-catenin signaling to regulate TCF/LEF-dependent gene expression. We have previously shown that β-catenin levels are
PMID 23266471

Differential regulation of Wnt/beta-catenin signaling by Liver X Receptors in Schwann cells and oligodendrocytes.

Shackleford G, Makoukji J, Grenier J, Liere P, Meffre D, Massaad C.SourceUniversity Paris Descartes, UMR 8194 CNRS, 45 rue des Saints-Pères, 75270, Paris Cedex 6, France.
Biochemical pharmacology.Biochem Pharmacol.2013 Mar 13. pii: S0006-2952(13)00163-9. doi: 10.1016/j.bcp.2013.02.036. [Epub ahead of print]
Oxysterols are reactive molecules generated by the oxidation of cholesterol. Their implication in cholesterol homeostasis and in the progression of neurodegenerative disorders is well known. Here, we study the role of oxysterols and their nuclear receptors, Liver X Receptor (LXR), in myelinating gli
PMID 23500534

Japanese Journal

柔道衣におけるはだけ現象と施技の基礎的実験

北陸大学紀要 = Bulletin of Hokuriku University (37), 2014-03-31
NAID 120005450526

ゴヤの《わが子を食べるサトゥルヌス》における「食べること」のイメージ

美學 62(2), 73-84, 2011-12-31
NAID 110009480053

Amplification, up-regulation and over-expression of DVL-1, the human counterpart of the Drosophila disheveled gene, in primary breast cancers

Cancer science 94(6), 515-518, 2003-06-30
NAID 50000864621

O,O-ジイソプロピル-S-ベンジルチオフォスフェート(IBP)処理によるイネの中茎伸長の抑制 : 第2報インド型イネに対する抑制効果

日本作物學會紀事 50(3), 262-266, 1981-09-25
NAID 110001729526

Related Pictures

cart cart lightbox lightbox share facebook Disheveled new design a brochure with this image disheveled aristocrat sounds perfect to me disheveled-woman loners do you ever see zombies just

★リンクテーブル★

リンク元

「unkempt」

Available protein structures:
Pfam	structures
PDB	RCSB PDB; PDBe; PDBj
PDBsum	structure summary

Dishevelled specific domain
	Solution structure of the mouse Dvl-1 DEP domain based on the PDB 1fsh coordinates.
Identifiers
Symbol	Dishevelled
Pfam	PF02377
InterPro	IPR003351
PROSITE	PDOC50841
Available protein structures:
Pfam	structures
PDB	RCSB PDB; PDBe; PDBj
PDBsum	structure summary

　　[★]

adj.

1.not combed: unkempt hair. 　←　櫛を入れていない、もじゃもじゃの、ぼさぼさの
2.uncared-for or neglected; disheveled; messy: unkempt clothes; an unkempt lawn. 　←　だらしのない、きちんとしていない(服装、外見、芝生)
3.unpolished; rough; crude.　←　粗野な、洗練されない

[pmid12072470-1] Penton A, Wodarz A, Nusse R (June 2002). "A mutational analysis of dishevelled in Drosophila defines novel domains in the dishevelled protein as well as novel suppressing alleles of axin". Genetics 161 (2): 747–62. PMC 1462152. PMID 12072470.

[pmid16192308-2] Wallingford JB, Habas R (October 2005). "The developmental biology of Dishevelled: an enigmatic protein governing cell fate and cell polarity". Development 132 (20): 4421–36. doi:10.1242/dev.02068. PMID 16192308. |accessdate= requires |url= (help)

[pmid18093802-3] Lee YN, Gao Y, Wang HY (February 2008). "Differential mediation of the Wnt canonical pathway by mammalian Dishevelleds-1, -2, and -3". Cell. Signal. 20 (2): 443–52. doi:10.1016/j.cellsig.2007.11.005. PMC 2233603. PMID 18093802.

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案内

disheveled