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1. 心血管疾患の危険因子の概要 overview of the possible risk factors for cardiovascular disease
2. 末期腎不全（透析）における冠動脈心疾患の危険因子および疫学 risk factors and epidemiology of coronary heart disease in end stage renal disease dialysis
3. 全身性エリテマトーデスにおける冠動脈疾患 coronary heart disease in systemic lupus erythematosus
4. 尿毒症毒素 uremic toxins
5. 鎌状赤血球症に伴う肺高血圧症 pulmonary hypertension associated with sickle cell disease

English Journal

Scott JA1, Grasemann H2.
Immunology and allergy clinics of North America.Immunol Allergy Clin North Am.2014 Nov;34(4):767-775. doi: 10.1016/j.iac.2014.07.007. Epub 2014 Aug 19.
Nitric oxide (NO) is important in the regulation of airway tone and airway responsiveness. Alterations in the l-arginine metabolism resulting in reduced availability of the substrate l-arginine for NO synthases, as well as the presence of NO synthase inhibitors such as asymmetric dimethylarginine, c
PMID 25282289

The ability of asymmetric dimethylarginine (ADMA) or monomethylarginine (L-NMMA) to block endothelium-dependent, nitric oxide-mediated relaxation in rat aorta is inversely related to the efficacy of the relaxant stimulus.

Al-Zobaidy MJ1, Martin W2.
European journal of pharmacology.Eur J Pharmacol.2014 Oct 15;741:171-7. doi: 10.1016/j.ejphar.2014.08.002. Epub 2014 Aug 19.
Previous work on rat aorta has shown that L-NMMA and ADMA each enhance vasoconstrictor-induced tone, consistent with blockade of basal nitric oxide activity, whereas they exert little inhibitory effect on acetylcholine-induced relaxation when tone is matched carefully to that of control tissues. The
PMID 25149663

Symmetric dimethylarginine alters endothelial nitric oxide activity in glomerular endothelial cells.

Feliers D1, Lee DY2, Gorin Y2, Kasinath BS2.
Cellular signalling.Cell Signal.2014 Oct 2. pii: S0898-6568(14)00328-3. doi: 10.1016/j.cellsig.2014.09.024. [Epub ahead of print]
Circulating symmetric dimethylarginine (SDMA) is increased in patients with chronic kidney disease. SDMA is considered an inert metabolite, but because it can transported into cells, we studied the effect of SDMA on glomerular endothelial cells. SDMA suppressed VEGF-induced endothelial nitric oxide
PMID 25283600

Tobacco Smoking Decreases Plasma Concentration of the Emerging Cardiovascular Risk Marker, L-Homoarginine

Sobczak Andrzej,Prokopowicz Adam,Radek Malgorzata [他]
Circulation journal : official journal of the Japanese Circulation Society 78(5), 1254-1258, 2014-05
NAID 40020045585

Investigating the Cardio-Protective Abilities of Supplemental L-Arginine on Parameters of Endothelial Function in a Hypercholesterolemic Animal Model

Z. GAD Mohamed,A. ABU EL MAATY Mohamed,A. EL-MARAGHY Shohda,T. FAHIM Atef,A. HAMDY Mohamed
Journal of Nutritional Science and Vitaminology 60(3), 145-151, 2014
… Biochemical investigations included measurement of circulating NOx, malondialdehyde (MDA), and lipid profile markers, as well as dimethylarginine dimethylaminohydrolase (DDAH) and ACE activities. …
NAID 130004678824