WordNet
- in the Christian era; used before dates after the supposed year Christ was born; "in AD 200" (同)A.D., anno_Domini
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出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2016/05/25 21:45:59」(JST)
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- 1. 心血管疾患の危険因子の概要 overview of the possible risk factors for cardiovascular disease
- 2. 末期腎不全（透析）における冠動脈心疾患の危険因子および疫学 risk factors and epidemiology of coronary heart disease in end stage renal disease dialysis
- 3. 尿毒症毒素 uremic toxins
- 4. 鎌状赤血球症に伴う肺高血圧症 pulmonary hypertension associated with sickle cell disease
- 5. 慢性腎臓病と冠動脈疾患 chronic kidney disease and coronary heart disease
English Journal
- Asymmetric dimethylarginine and critical illness.
- Brinkmann SJ, de Boer MC, Buijs N, van Leeuwen PA.Author information aDepartment of Plastic and Reconstructive Surgery bDepartment of Surgery, VU University Medical Center, Amsterdam, the Netherlands.AbstractPURPOSE OF REVIEW: Asymmetric dimethylarginine (ADMA) is an analog of arginine and functions as an endogenous inhibitor of the nitric oxide synthase, which forms nitric oxide. Nitric oxide is crucial for perfusion of vital organs and is an important signaling agent in the development of critical illness. The role of ADMA in the pathophysiological mechanisms underlying critical illness is widely studied in the last decades, and recently it has become clear that ADMA should not be overlooked by clinicians working at the ICU. The aim of this review is to describe new insights into the role of ADMA in critical illness and its clinical relevance.
- Current opinion in clinical nutrition and metabolic care.Curr Opin Clin Nutr Metab Care.2014 Jan;17(1):90-7. doi: 10.1097/MCO.0000000000000020.
- PURPOSE OF REVIEW: Asymmetric dimethylarginine (ADMA) is an analog of arginine and functions as an endogenous inhibitor of the nitric oxide synthase, which forms nitric oxide. Nitric oxide is crucial for perfusion of vital organs and is an important signaling agent in the development of critical ill
- PMID 24281375
- A novel and potent inhibitor of dimethylarginine dimethylaminohydrolase: a modulator of cardiovascular nitric oxide.
- Ghebremariam YT, Erlanson DA, Cooke JP.Author information Department of Cardiovascular Sciences, Houston Methodist Research Institute, Houston, Texas (Y.T.G., J.P.C.); and SPARK Translational Research Program, Stanford University, School of Medicine, Stanford, California (D.A.E.).AbstractPD 404182 [6H-6-imino-(2,3,4,5-tetrahydropyrimido)[1,2-c]-[1,3]benzothiazine], a heterocyclic iminobenzothiazine derivative, is a member of the Library of Pharmacologically Active Compounds (LOPAC) that is reported to possess antimicrobial and anti-inflammatory properties. In this study, we used biochemical assays to screen LOPAC against human dimethylarginine dimethylaminohydrolase isoform 1 (DDAH1), an enzyme that physiologically metabolizes asymmetric dimethylarginine (ADMA), an endogenous and competitive inhibitor of nitric oxide (NO) synthase. We discovered that PD 404182 directly and dose-dependently inhibits DDAH. Moreover, PD 404182 significantly increased intracellular levels of ADMA in cultured primary human vascular endothelial cells (ECs) and reduced lipopolysaccharide-induced NO production in these cells, suggesting its therapeutic potential in septic shock-induced vascular collapse. In addition, PD 404182 abrogated the formation of tube-like structures by ECs in an in vitro angiogenesis assay, indicating its antiangiogenic potential in diseases characterized by pathologically excessive angiogenesis. Furthermore, we investigated the potential mechanism of inhibition of DDAH by this small molecule and found that PD 404182, which has striking structural similarity to ADMA, could be competed by a DDAH substrate, suggesting that it is a competitive inhibitor. Finally, our enzyme kinetics assay showed time-dependent inhibition, and our inhibitor dilution assay showed that the enzymatic activity of DDAH did not recover significantly after dilution, suggesting that PD 404182 might be a tightly bound, covalent, or an irreversible inhibitor of human DDAH1. This proposal is supported by mass spectrometry studies with PD 404182 and glutathione.
- The Journal of pharmacology and experimental therapeutics.J Pharmacol Exp Ther.2014 Jan;348(1):69-76. doi: 10.1124/jpet.113.206847. Epub 2013 Oct 17.
- PD 404182 [6H-6-imino-(2,3,4,5-tetrahydropyrimido)[1,2-c]-[1,3]benzothiazine], a heterocyclic iminobenzothiazine derivative, is a member of the Library of Pharmacologically Active Compounds (LOPAC) that is reported to possess antimicrobial and anti-inflammatory properties. In this study, we used bio
- PMID 24135074
- Two different approaches to restore renal nitric oxide and prevent hypertension in young spontaneously hypertensive rats: l-citrulline and nitrate.
- Chien SJ1, Lin KM1, Kuo HC1, Huang CF1, Lin YJ1, Huang LT2, Tain YL3.Author information 1Department of Pediatrics, Kaohsiung Chang Gung Memorial Hospital and Chang Gung University, College of Medicine, Kaohsiung, Taiwan.2Department of Pediatrics, Kaohsiung Chang Gung Memorial Hospital and Chang Gung University, College of Medicine, Kaohsiung, Taiwan; Department of Traditional Chinese Medicine, Chang Gung University, Linkow, Taiwan.3Department of Pediatrics, Kaohsiung Chang Gung Memorial Hospital and Chang Gung University, College of Medicine, Kaohsiung, Taiwan; Center for Translational Research in Biomedical Sciences, Kaohsiung Chang Gung Memorial Hospital and Chang Gung University, College of Medicine, Kaohsiung, Taiwan. Electronic address: tainyl@hotmail.com.AbstractNitric oxide (NO) deficiency mediates oxidative stress in the kidney and is involved in the development of hypertension. NO synthesis occurs via 2 pathways: nitric oxide synthase (NOS) dependent and NOS-independent. We tested whether the development of hypertension is prevented by restoration of NO by dietary l-citrulline or nitrate supplementation in young spontaneously hypertensive rats (SHRs). Male SHRs and normotensive Wistar Kyoto control rats (WKYs)s age 4 weeks were assigned to 4 groups: untreated SHRs and WKYs, and SHRs and WKYs that received 0.25% l-citrulline for 8 weeks. In our second series of studies, we replaced l-citrulline with 1 mmol/kg/d sodium nitrate. All rats were sacrificed at age 12 weeks. We found an increase in the blood pressure of SHRs was prevented by dietary supplementation of l-citrulline or nitrate. Both treatments restored NO bioavailability and reduced oxidative stress in SHR kidneys. l-Citrulline therapy reduced levels of l-arginine and asymmetric dimethylarginine (ADMA)-an endogenous inhibitor of NOS-and increased the l-arginine-to-ADMA ratio in SHR kidneys. Nitrate treatment reduced plasma levels of l-arginine and ADMA concurrently in SHRs. Our findings suggest that both NOS-dependent and -independent approaches in the prehypertensive stage toward augmentation of NO can prevent the development of hypertension in young SHRs.
- Translational research : the journal of laboratory and clinical medicine.Transl Res.2014 Jan;163(1):43-52. doi: 10.1016/j.trsl.2013.09.008. Epub 2013 Oct 8.
- Nitric oxide (NO) deficiency mediates oxidative stress in the kidney and is involved in the development of hypertension. NO synthesis occurs via 2 pathways: nitric oxide synthase (NOS) dependent and NOS-independent. We tested whether the development of hypertension is prevented by restoration of NO
- PMID 24113064
Japanese Journal
- 2型糖尿病患者における心・脳-腎連関
- 坊内 良太郎,馬場園 哲也,花井 豪,岩本 安彦
- 東京女子医科大学雑誌 81(E2), E135-E140, 2011-03-31
- … (2)CKDと無症候性脳梗塞(SCI)との関連に関する横断面および前向き観察研究、さらには(3)脳・心-腎連関の機序を説明する因子として、血管内皮障害マーカーであるasymmetric dimethylarginine(ADMA)に注目し、血中ADMAレベルがCVD発症および腎症進展に及ぼす影響について検討した.,(1)2型糖尿病患者において、アルブミン尿は症候性脳卒中の新規発症と関連したが、eGFR低下の影響は有意でなかった.一方冠 …
- NAID 110008441458
- Quantitation of L-Arginine and Asymmetric Dimethylarginine in Human Plasma by LC-Selective Ion Mode-MS for Type 2 Diabetes Mellitus Study
- Yi Lunzhao,Zhang Pengfei,Ji Xiaoyan,Liang Yizeng,Wang Yamin,Zhou Zhiguang,Chen Benmei
- CHEMICAL & PHARMACEUTICAL BULLETIN 59(7), 839-843, 2011
- … The article reports a simple, sensitive and fast LC/MS method for the analysis of L-arginine (L-Arg), asymmetric dimethylarginine (ADMA) and symmetric dimethylarginine (SDMA) in human plasma. … The chromatographic separation was achieved on C18 (150 mm×2.1 mm, 5 μm) column with a mobile phase consisting of ammonium acetate (0.25 mmol/l) and methanol (93 : 7, v/v), at a flow rate of 0.2 ml/min. L-Arg, ADMA and SDMA were well separated by LC/MS with selective ion mode (SIM). …
- NAID 130000748016
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「非対称性ジメチルアルギニン」
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