dihydroalprenolol

ジヒドロアルプレノロール

Wikipedia preview

出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2014/06/10 16:50:04」(JST)

wiki en

[Wiki en表示]

Dihydroalprenolol
IUPAC name 1-(Isopropylamino)-3-(2-propylphenoxy)-2-propanol
Identifiers
CAS number	60106-89-0
PubChem	43216
ChemSpider	39384
Jmol-3D images	Image 1
SMILES CCCC1=CC=CC=C1OCC(CNC(C)C)O
InChI InChI=1S/C15H25NO2/c1-4-7-13-8-5-6-9-15(13)18-11-14(17)10-16-12(2)3/h5-6,8-9,12,14,16-17H,4,7,10-11H2,1-3H3 Key: JVHCMYZFGCOCTD-UHFFFAOYSA-N
Properties
Molecular formula	C15H25NO2
Molar mass	251.36 g mol−1
Except where noted otherwise, data are given for materials in their standard state (at 25 °C (77 °F), 100 kPa)
Infobox references

Dihydroalprenolol (DHA) is a hydrogenated alprenolol derivative that acts as a beta-adrenergic blocker. When the extra hydrogen atoms are tritium, it is a radiolabeled form of alprenolol which is used to label beta-adrenergic receptors for isolation.

References

English Journal

• Slow receptor dissociation is not a key factor in the duration of action of inhaled long-acting β2-adrenoceptor agonists.

• Sykes DA, Charlton SJ.SourceNovartis Institutes for Biomedical Research, West Sussex, UK.
• British journal of pharmacology.Br J Pharmacol.2012 Apr;165(8):2672-83. doi: 10.1111/j.1476-5381.2011.01639.x.
• BACKGROUND AND PURPOSE: β(2) -Adrenoceptor agonists are important bronchodilators used for the treatment of chronic obstructive pulmonary disease and asthma. Clinical data on β(2) -adrenoceptor agonists show a range of onset and duration of action. We have investigated whether the receptor binding
• PMID 21883146

• N-terminal T4 lysozyme fusion facilitates crystallization of a G protein coupled receptor.

• Zou Y, Weis WI, Kobilka BK.SourceDepartment of Molecular and Cellular Physiology, Stanford University School of Medicine, Stanford, California, United States of America.
• PloS one.PLoS One.2012;7(10):e46039. doi: 10.1371/journal.pone.0046039. Epub 2012 Oct 4.
• A highly crystallizable T4 lysozyme (T4L) was fused to the N-terminus of the β(2) adrenergic receptor (β(2)AR), a G-protein coupled receptor (GPCR) for catecholamines. We demonstrate that the N-terminal fused T4L is sufficiently rigid relative to the receptor to facilitate crystallogenesis without
• PMID 23056231

• Glutaminyl cyclase contributes to the formation of focal and diffuse pyroglutamate (pGlu)-Aβ deposits in hippocampus via distinct cellular mechanisms.

• Hartlage-Rübsamen M, Morawski M, Waniek A, Jäger C, Zeitschel U, Koch B, Cynis H, Schilling S, Schliebs R, Demuth HU, Rossner S.SourcePaul Flechsig Institute for Brain Research, University of Leipzig, Germany.
• Acta neuropathologica.Acta Neuropathol.2011 Jun;121(6):705-19. doi: 10.1007/s00401-011-0806-2. Epub 2011 Feb 8.
• In the hippocampal formation of Alzheimer's disease (AD) patients, both focal and diffuse deposits of Aβ peptides appear in a subregion- and layer-specific manner. Recently, pyroglutamate (pGlu or pE)-modified Aβ peptides were identified as a highly pathogenic and seeding Aβ peptide species. Sinc
• PMID 21301857

Japanese Journal

• Binding of a Catechol Derivative of Denopamine (T-0509) and N-tert-Butylnoradrenaline (Colterol) to β_1-and β_2-Adrenoceptors

• 草山 俊之,岡 淳一郎,矢花 秀雄,赤羽 悟美,長尾 拓
• Ｂｉｏｌｏｇｉｃａｌ　＆　Ｐｈａｒｍａｃｅｕｔｉｃａｌ　Ｂｕｌｌｅｔｉｎ 17(8), 1023-1028, 1994-08-15
• … Specific binding of [^3H] dihydroalprenolol (^3H-DHA) to guinea pig left ventricular and lung membranes was saturable, and Scatchard and Hill analyses suggested that ^3H-DHA bound to both membranes with a single population of binding sites with no binding site cooperativity. …
• NAID 110003640699

• Differences in Adrenergic Nerve and Receptor Function in Dog Internal Thoracic, Coronary and Mesenteric Arteries.

• Shiraishi Shoichiro,Okamura Tomio,Mori Atsumi,Toda Noboru
• The Japanese Journal of Pharmacology 66(4), 481-488, 1994
• … The β-adrenoceptor density, assayed by [<SUP>3</SUP>H]dihydroalprenolol binding, was markedly less in ITA than in coronary arteries. …
• NAID 130000840727

• Characterization of .BETA.-Adrenoceptors in Pig Basilar Artery from Functional and Radioligand Binding Studies.

• Miyamoto Atsushi,Ito Ken,Nishio Akira
• The Japanese Journal of Pharmacology 61(2), 93-99, 1993
• … β-Adrenoceptors in pig basilar arteries were investigated by measuring the relaxation responses to norepinephrine and by a radioligand binding assay with [<SUP>3</SUP>H]-dihydroalprenolol (DHA). …
• NAID 130000840234

Related Links

• dihydroalprenolol

Species, Scientific Experts, Genomes and Genes, Research Grants, Publications, Research Topics about dihydroalprenolol ... ..The purpose of this study is to investigate if the aqueous extract of the Chinese medicine Danggui ...

• dihydroalprenolol - Definition

dihydroalprenolol definition from the mondofacto online medical dictionary ... Search dictionary help dihydroalprenolol medical dictionary <chemical> Hydrogenated alprenolol derivative where the extra hydrogens are often tritiated. This radiolabelled ...

Related Pictures

---

★リンクテーブル★

リンク元	「ジヒドロアルプレノロール」

「ジヒドロアルプレノロール」

　　[★]

英

dihydroalprenolol

関

アルプレノロール、アドレナリン受容体

• 非選択的β遮断薬