ジアシルグリセロールコリンホスホトランスフェラーゼ
- 関
- cholinephosphotransferase
Wikipedia preview
出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2016/01/23 01:08:35」(JST)
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| diacylglycerol cholinephosphotransferase |
| Identifiers |
| EC number |
2.7.8.2 |
| CAS number |
9026-13-5 |
| Databases |
| IntEnz |
IntEnz view |
| BRENDA |
BRENDA entry |
| ExPASy |
NiceZyme view |
| KEGG |
KEGG entry |
| MetaCyc |
metabolic pathway |
| PRIAM |
profile |
| PDB structures |
RCSB PDB PDBe PDBsum |
| Gene Ontology |
AmiGO / EGO |
| Search |
| PMC |
articles |
| PubMed |
articles |
| NCBI |
proteins |
|
In enzymology, a diacylglycerol cholinephosphotransferase (EC 2.7.8.2) is an enzyme that catalyzes the chemical reaction
CDP-choline + 1,2-diacylglycerol CMP + a phosphatidylcholine
Thus, the two substrates of this enzyme are CDP-choline and 1,2-diacylglycerol, whereas its two products are CMP and phosphatidylcholine.[1]
Contents
- 1 Classification
- 2 Nomenclature
- 3 Biological role
- 4 References
Classification
This enzyme belongs to the family of transferases, specifically those transferring non-standard substituted phosphate groups.
Nomenclature
The systematic name of this enzyme class is CDP choline:1,2-diacylglycerol cholinephosphotransferase. Other names in common use include:
- 1-alkyl-2-acetyl-m-glycerol:CDPcholine choline phosphotransferase,
- 1-alkyl-2-acetyl-sn-glycerol cholinephosphotransferase,
- 1-alkyl-2-acetylglycerol cholinephosphotransferase,
- alkylacylglycerol choline phosphotransferase,
- alkylacylglycerol cholinephosphotransferase,
- CDP-choline diglyceride phosphotransferase,
- cholinephosphotransferase,
- CPT,
- cytidine diphosphocholine glyceride transferase,
- cytidine diphosphorylcholine diglyceride transferase,
- diacylglycerol choline phosphotransferase,
- phosphocholine diacylglyceroltransferase,
- phosphorylcholine-glyceride transferase, and
- sn-1,2-diacylglycerol cholinephosphotransferase.
Biological role
This enzyme participates in 3 metabolic pathways: aminophosphonate metabolism, glycerophospholipid metabolism, and ether lipid metabolism.
References
- ^ Coleman R, Bell RM (1977). "Phospholipid synthesis in isolated fat cells. Studies of microsomal diacylglycerol cholinephosphotransferase and diacylglycerol ethanolaminephosphotransferase activities". J. Biol. Chem. 252 (9): 3050–6. PMID 192727.
- Lee TC, Blank ML, Fitzgerald V, Snyder F (1982). "Formation of alkylacyl- and diacylglycerophosphocholines via diradylglycerol cholinephosphotransferase in rat liver". Biochim. Biophys. Acta. 713 (2): 479–83. doi:10.1016/0005-2760(82)90269-7. PMID 6295501.
- Parthasarathy S, Cady RK, Kraushaar DS, Sladek NE, Baumann WJ (1978). "Inhibition of diacylglycerol:CDPcholine cholinephosphotransferase activity by dimethylaminoethyl p-chlorophenoxyacetate". Lipids. 13 (2): 161–4. doi:10.1007/BF02533260. PMID 204847.
- Renooij W, Snyder F (1981). "Biosynthesis of 1-alkyl-2-acetyl-sn-glycero-3-phosphocholine (platelet activating factor and a hypotensive lipid) by cholinephosphotransferase in various rat tissues". Biochim. Biophys. Acta. 663 (2): 545–56. doi:10.1016/0005-2760(81)90182-x. PMID 6260215.
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Transferases: phosphorus-containing groups (EC 2.7)
|
|
2.7.1-2.7.4:
phosphotransferase/kinase
(PO4) |
| 2.7.1: OH acceptor |
- Hexo-
- Gluco-
- Fructo-
- Galacto-
- Phosphofructo-
- 1
- Liver
- Muscle
- Platelet
- 2
- Riboflavin
- Shikimate
- Thymidine
- NAD+
- Glycerol
- Pantothenate
- Mevalonate
- Pyruvate
- Deoxycytidine
- PFP
- Diacylglycerol
- Phosphoinositide 3
- Class I PI 3
- Class II PI 3
- Sphingosine
- Glucose-1,6-bisphosphate synthase
|
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| 2.7.2: COOH acceptor |
- Phosphoglycerate
- Aspartate kinase
|
|
| 2.7.3: N acceptor |
|
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| 2.7.4: PO4 acceptor |
- Phosphomevalonate
- Adenylate
- Nucleoside-diphosphate
- Uridylate
- Guanylate
- Thiamine-diphosphate
|
|
|
2.7.6: diphosphotransferase
(P2O7) |
- Ribose-phosphate diphosphokinase
- Thiamine diphosphokinase
|
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2.7.7: nucleotidyltransferase
(PO4-nucleoside) |
| Polymerase |
| DNA polymerase |
- DNA-directed DNA polymerase
- I
- II
- III
- IV
- V
- RNA-directed DNA polymerase
- Reverse transcriptase
- Telomerase
- DNA nucleotidylexotransferase/Terminal deoxynucleotidyl transferase
|
|
| RNA nucleotidyltransferase |
- RNA polymerase/DNA-directed RNA polymerase
- RNA polymerase I
- RNA polymerase II
- RNA polymerase III
- RNA polymerase IV
- Primase
- RNA-dependent RNA polymerase
- PNPase
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Phosphorolytic
3' to 5' exoribonuclease |
|
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| Nucleotidyltransferase |
- UTP—glucose-1-phosphate uridylyltransferase
- Galactose-1-phosphate uridylyltransferase
|
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| Guanylyltransferase |
|
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| Other |
- Recombinase (Integrase)
- Transposase
|
|
|
| 2.7.8: miscellaneous |
| Phosphatidyltransferases |
- CDP-diacylglycerol—glycerol-3-phosphate 3-phosphatidyltransferase
- CDP-diacylglycerol—serine O-phosphatidyltransferase
- CDP-diacylglycerol—inositol 3-phosphatidyltransferase
- CDP-diacylglycerol—choline O-phosphatidyltransferase
|
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| Glycosyl-1-phosphotransferase |
- N-acetylglucosamine-1-phosphate transferase
|
|
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2.7.10-2.7.13: protein kinase
(PO4; protein acceptor) |
| 2.7.10: protein-tyrosine |
|
|
| 2.7.11: protein-serine/threonine |
- see serine/threonine-specific protein kinases
|
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| 2.7.12: protein-dual-specificity |
- see serine/threonine-specific protein kinases
|
|
| 2.7.13: protein-histidine |
- Protein-histidine pros-kinase
- Protein-histidine tele-kinase
- Histidine kinase
|
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- Biochemistry overview
- Enzymes overview
- By EC number: 1.1
- 2
- 3
- 4
- 5
- 6
- 7
- 8
- 9
- 10
- 11
- 12
- 13
- 14
- 15-99
- 2.1
- 3.1
- 4.1
- 5.1
- 6.1-3
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Proteins: enzymes
|
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| Activity |
- Active site
- Binding site
- Catalytic triad
- Oxyanion hole
- Enzyme promiscuity
- Catalytically perfect enzyme
- Coenzyme
- Cofactor
- Enzyme catalysis
- Enzyme kinetics
- Lineweaver–Burk plot
- Michaelis–Menten kinetics
|
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| Regulation |
- Allosteric regulation
- Cooperativity
- Enzyme inhibitor
|
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| Classification |
- EC number
- Enzyme superfamily
- Enzyme family
- List of enzymes
|
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| Types |
- EC1 Oxidoreductases(list)
- EC2 Transferases(list)
- EC3 Hydrolases(list)
- EC4 Lyases(list)
- EC5 Isomerases(list)
- EC6 Ligases(list)
|
|
- Biochemistry overview
- Enzymes overview
- By EC number: 1.1
- 2
- 3
- 4
- 5
- 6
- 7
- 8
- 9
- 10
- 11
- 12
- 13
- 14
- 15-99
- 2.1
- 3.1
- 4.1
- 5.1
- 6.1-3
|
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|
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UpToDate Contents
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- 1. T細胞受容体シグナル伝達t cell receptor signaling [show details]
…nucleotide-releasing protein (RasGRP) is also recruited to the plasma membrane upon generation of diacylglycerol (DAG) and activated by protein kinase C (PKC)-theta-mediated serine phosphorylation. SLP-76 is also …
- 2. 成人の急性腎障害に伴う血栓性微小血管症thrombotic microangiopathies with acute kidney injury in adults [show details]
…THBD – Encodes thrombomodulin, which also has roles in the coagulation cascade; DGKE – Encodes diacylglycerol kinase epsilon, which also appears to have a role in some forms of nephrotic syndrome; The CFH-CFHR…
- 3. ペプチドホルモンのシグナル伝達および調節peptide hormone signal transduction and regulation [show details]
…PLC can cause the hydrolysis of phosphatidylinositol 4,5 bisphosphate (PIP2) to 1,2 diacylglycerol and IP3. Diacylglycerol and IP3 can then act as regulators of cell metabolism. This pathway can alter cell …
- 4. 小児における溶血性尿毒症症候群の概要overview of hemolytic uremic syndrome in children [show details]
…function results in a prothrombotic state as DGKE inactivates arachidonic acid-containing diacylglycerols (DAG), an activator of protein kinase C, which promotes thrombosis. In one consanguineous family …
- 5. 血小板生物学platelet biology [show details]
… receptors . PKC has been identified as the cellular receptor for the lipid second messenger diacylglycerol (DAG), and it is therefore a key enzyme in the signaling events that follow activation of receptors …
English Journal
- Two phylogenetically and compartmentally distinct CDP-diacylglycerol synthases cooperate for lipid biogenesis in Toxoplasma gondii.
- Kong P1, Ufermann CM1, Zimmermann DLM1, Yin Q2, Suo X2, Helms JB3, Brouwers JF3, Gupta N4.
- The Journal of biological chemistry.J Biol Chem.2017 Apr 28;292(17):7145-7159. doi: 10.1074/jbc.M116.765487. Epub 2017 Mar 17.
- PMID 28314772
- 1,2-Diacylglycerol choline phosphotransferase catalyzes the final step in the unique Treponema denticola phosphatidylcholine biosynthesis pathway.
- Vences-Guzmán MÁ1, Paula Goetting-Minesky M2, Guan Z3, Castillo-Ramirez S1, Córdoba-Castro LA1, López-Lara IM1, Geiger O1, Sohlenkamp C1, Christopher Fenno J2.
- Molecular microbiology.Mol Microbiol.2017 Mar;103(5):896-912. doi: 10.1111/mmi.13596. Epub 2017 Jan 17.
- PMID 28009086
- Estrogen Receptor α Promotes Breast Cancer by Reprogramming Choline Metabolism.
- Jia M1, Andreassen T2, Jensen L3, Bathen TF4, Sinha I5, Gao H5, Zhao C5, Haldosen LA5, Cao Y6, Girnita L7, Moestue SA4, Dahlman-Wright K1.
- Cancer research.Cancer Res.2016 Oct 1;76(19):5634-5646. Epub 2016 Jul 25.
- PMID 27457520
Japanese Journal
- CDPcholine : 1,2-diacylglycerol cholinephosphotransferase from rat liver microsomes. I. Solubilization and characterization of the partially purified enzyme and the possible existence of an endogenous inhibitor
- CDP-CHOLINE : 1,2-DIACYLGLYCEROL CHOLINEPHOSPHOTRANSFERASE FROM RAT LIVER MICROSOMES : Photoaffinity Labeling by Radioactive CDP-Choline Analogs
- ISHIDATE Kozo,MATSUO Ritsuko,NAKAZAWA Yasuo
- Journal of pharmacobio-dynamics 15(6), "s-63", 1992-06
- NAID 110003637572
- Utilization of diacylglycerol species by cholinephosphotransferase, ethanolaminephosphotransferase and diacylglycerol acyltransferase in rat liver microsomes
★リンクテーブル★
[★]
- 英
- diacylglycerol cholinephosphotransferase
- 関
- コリンホスホトランスフェラーゼ
[★]
コリンホスホトランスフェラーゼ
- 関
- diacylglycerol cholinephosphotransferase
[★]
ジアシルグリセロール。DG DAG