イソニコチン酸デキサメタゾン

WordNet

a corticosteroid drug (trade names Decadron or Dexamethasone Intensol or Dexone or Hexadrol or Oradexon) used to treat allergies or inflammation (同)Decadron, Dexamethasone Intensol, Dexone, Hexadrol, Oradexon

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出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2016/01/20 11:43:52」(JST)

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Dexamethasone isonicotinate is an anti-inflammatory, anti-allergic glucocorticoid that can be administered orally, by inhalation, locally, and parenterally. It may cause salt and water retention.

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1. 小児における細菌性髄膜炎：神経学的合併症を予防するデキサメタゾンおよびその他の対策 bacterial meningitis in children dexamethasone and other measures to prevent neurologic complications
2. デキサメタゾン抑制試験 dexamethasone suppression tests
3. 成人における細菌性髄膜炎の神経学的合併症予防のためのデキサメタゾン dexamethasone to prevent neurologic complications of bacterial meningitis in adults
4. クループ：薬剤および補助治療 croup pharmacologic and supportive interventions
5. 早産による新生児呼吸促迫症候群の罹病率と死亡率を減少させるための妊婦への出生前ステロイド投与 antenatal corticosteroid therapy for reduction of neonatal respiratory morbidity and mortality from preterm delivery

English Journal

Effects of Dexamethasone-21-Isonicotinate on Peripheral Insulin Action in Dairy Cows 5 days after Surgical Correction of Abomasal Displacement.

Kusenda M, Kaske M, Piechotta M, Locher L, Starke A, Huber K, Rehage J.SourceClinic for Cattle, University of Veterinary Medicine Hannover, 30173, Hannover, Germany.
Journal of veterinary internal medicine / American College of Veterinary Internal Medicine.J Vet Intern Med.2012 Nov 29. doi: 10.1111/jvim.12010. [Epub ahead of print]
BACKGROUND: Dexamethasone frequently is used for treatment of ketosis in dairy cows, but its effects are not fully understood.HYPOTHESIS: Dexamethasone treatment affects whole body insulin sensitivity.ANIMALS: Twelve German Holstein cows, 2-4 weeks postpartum, 5 days after omentopexy to correct le
PMID 23194055

Effects of anabolic and therapeutic doses of dexamethasone on thymus morphology and apoptosis in veal calves.

Cannizzo FT, Miniscalco B, Riondato F, Bollo E, Barbarino G, Giorgi P, Mazzini C, Biolatti B.SourceDipartimento di Patalogia Animale, University of Turin, via L. Da Vinci 44, 10095 Grugliasco, TO, Italy.
The Veterinary record.Vet Rec.2008 Oct 11;163(15):448-52.
Three groups of 10 veal calves were treated, respectively, with 5 mg of dexamethasone-21-isonicotinate administered intramuscularly on days 0 and 7 (group A); 0.4 mg/day of dexamethasone-21-phosphate administered orally for 20 days (group B); or left untreated as controls (group C). Two animals from
PMID 18849577

Japanese Journal

気管内吸入用Dexamethasone-21-isonicotinate(He111)のマウス,ラットによる急性毒性

樋田晋 [他]
東邦医学会雑誌 20(5・6), 769-771, 1973-12
NAID 40018140493

気管内吸入用Dexamethasone-21-isonicotinate(He111)の一般薬理-1-

内山利満 [他]
東邦医学会雑誌 20(5・6), 765-768, 1973-12
NAID 40018140492

気管内吸入用Dexamethasone-21-isonicotinate(He111)のラットによる亜急性および慢性毒性

伊藤隆太 [他]
東邦医学会雑誌 20(5・6), 611-632, 1973-12
NAID 40018140481

「イソニコチン酸デキサメタゾン」

Dexamethasone isonicotinate
Names
	IUPAC name [2-[(8S,9R,10S,11S,13S,14S,16R,17R)-9-fluoro-11,17-dihydroxy-10,13,16-trimethyl-3-oxo-6,7,8,11,12,14,15,16-octahydrocyclopenta[a]phenanthren-17-yl]-2-oxoethyl]pyridine-4-carboxylate
	Other names Auxiloson/ Dexamethasone 21-isonicotinate/ Auxilson/ Auxilsone/ Voren/ DEXAMETHASONE ISONICOTINATE/ EINECS 218-866-5/ HE 111/ 2265-64-7/ Pyridine-4-carboxylic acid-(dexamethasone-21') ester/ Pyridin-4-carbonsaeure-(dexamethason-21')-ester [German]/ Pregna-1,4-diene-3,20-dione, 9-fluoro-11,17-dihydroxy-16-methyl-21-((4-pyridinylcarbonyl)oxy)-, (11beta,16alpha)/ Pregna-1,4-diene-3,20-dione, 9-fluoro-11-beta,17,21-trihydroxy-16-alpha-methyl-, 21-isonicotinate/ Auxison/ Voren [veterinary] (TN)/ UNII-8LGC0BOA71/ AC1L28M0/ C28H32FNO6/ HE-111/ LS-118477/ D07797/ Pyridin-4-carbonsaeure-(dexamethason-21')-ester/ Pregna-1,4-diene-3,20-dione, 9-fluoro-11-beta,17,21-trihydroxy-16-alpha-methyl-,21-isonicotinate
Identifiers
CAS Number	2265-64-7
ChemSpider	15881
Jmol interactive 3D	Image
PubChem	16752
UNII	8LGC0BOA71
	InChI InChI=1/C28H32FNO6/c1-16-12-21-20-5-4-18-13-19(31)6-9-25(18,2)27(20,29)22(32)14-26(21,3)28(16,35)23(33)15-36-24(34)17-7-10-30-11-8-17/h6-11,13,16,20-22,32,35H,4-5,12,14-15H2,1-3H3/t16-,20+,21+,22+,25+,26+,27+,28+/m1/s1 Key: BQTXJHAJMDGOFI-NJLPOHDGBY ;
	SMILES O=C(OCC(=O)[C@@]3(O)[C@H](C)C[C@H]2[C@@H]4CCC\1=C\C(=O)\C=C/[C@]/1(C)[C@@]4(F)[C@@H](O)C[C@@]23C)c5ccncc5 ;
Properties
Chemical formula	C28H32FNO6
Molar mass	497.56 g/mol
	Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).
	Infobox references

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英: dexamethasone isonicotinate

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dexamethasone isonicotinate