デスモグレイン3
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出典(authority):フリー百科事典『ウィキペディア(Wikipedia)』「2015/11/24 10:09:41」(JST)
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Desmoglein 3 |
Identifiers |
Symbols |
DSG3 ; CDHF6; PVA |
External IDs |
OMIM: 169615 MGI: 99499 HomoloGene: 55513 GeneCards: DSG3 Gene |
Gene ontology |
Molecular function |
• calcium ion binding
|
Cellular component |
• cytosol
• plasma membrane
• integral component of membrane
• desmosome
• extracellular exosome
|
Biological process |
• apoptotic process
• cellular component disassembly involved in execution phase of apoptosis
• homophilic cell adhesion via plasma membrane adhesion molecules
• programmed cell death
|
Sources: Amigo / QuickGO |
|
RNA expression pattern |
|
More reference expression data |
Orthologs |
Species |
Human |
Mouse |
Entrez |
1830 |
13512 |
Ensembl |
ENSG00000134757 |
ENSMUSG00000056632 |
UniProt |
P32926 |
n/a |
RefSeq (mRNA) |
NM_001944 |
NM_030596 |
RefSeq (protein) |
NP_001935 |
NP_085099 |
Location (UCSC) |
Chr 18:
31.45 – 31.48 Mb |
Chr 18:
20.51 – 20.54 Mb |
PubMed search |
[1] |
[2] |
|
Desmoglein-3 is a protein that in humans is encoded by the DSG3 gene.[1][2]
Contents
- 1 Function
- 2 Interactions
- 3 See also
- 4 References
- 5 Further reading
Function
Desmosomes are cell-cell junctions between epithelial, myocardial, and certain other cell types. Desmoglein 3 is a calcium-binding transmembrane glycoprotein component of desmosomes in vertebrate epithelial cells. Currently, four desmoglein subfamily members have been identified and all are members of the cadherin cell adhesion molecule superfamily. These desmoglein gene family members are located in a cluster on chromosome 18. This protein has been identified as the autoantigen of the autoimmune skin blistering disease pemphigus vulgaris.[2]
Interactions
Desmoglein 3 has been shown to interact with PKP3.[3]
See also
- Desmoglein
- List of target antigens in pemphigus
- List of conditions caused by problems with junctional proteins
References
- ^ Arnemann J, Spurr NK, Buxton RS (Jul 1992). "The human gene (DSG3) coding for the pemphigus vulgaris antigen is, like the genes coding for the other two known desmogleins, assigned to chromosome 18". Hum Genet 89 (3): 347–50. doi:10.1007/bf00220557. PMID 1601426.
- ^ a b "Entrez Gene: DSG3 desmoglein 3 (pemphigus vulgaris antigen)".
- ^ Bonné S, Gilbert B, Hatzfeld M, Chen X, Green KJ, van Roy F (April 2003). "Defining desmosomal plakophilin-3 interactions". J. Cell Biol. 161 (2): 403–16. doi:10.1083/jcb.200303036. PMC 2172904. PMID 12707304.
Further reading
- Amagai M, Klaus-Kovtun V, Stanley JR (1992). "Autoantibodies against a novel epithelial cadherin in pemphigus vulgaris, a disease of cell adhesion". Cell 67 (5): 869–77. doi:10.1016/0092-8674(91)90360-B. PMID 1720352.
- Roh JY, Stanley JR (1995). "Plakoglobin binding by human Dsg3 (pemphigus vulgaris antigen) in keratinocytes requires the cadherin-like intracytoplasmic segment". J. Invest. Dermatol. 104 (5): 720–4. doi:10.1111/1523-1747.ep12606963. PMID 7738346.
- Wang Y, Amagai M, Minoshima S; et al. (1994). "The human genes for desmogleins (DSG1 and DSG3) are located in a small region on chromosome 18q12". Genomics 20 (3): 492–5. doi:10.1006/geno.1994.1207. PMID 8034325.
- Schäfer S, Koch PJ, Franke WW (1994). "Identification of the ubiquitous human desmoglein, Dsg2, and the expression catalogue of the desmoglein subfamily of desmosomal cadherins". Exp. Cell Res. 211 (2): 391–9. doi:10.1006/excr.1994.1103. PMID 8143788.
- Kárpáti S, Amagai M, Prussick R; et al. (1993). "Pemphigus vulgaris antigen, a desmoglein type of cadherin, is localized within keratinocyte desmosomes". J. Cell Biol. 122 (2): 409–15. doi:10.1083/jcb.122.2.409. PMC 2119642. PMID 8320263.
- Silos SA, Tamai K, Li K; et al. (1996). "Cloning of the gene for human pemphigus vulgaris antigen (desmoglein 3), a desmosomal cadherin. Characterization of the promoter region and identification of a keratinocyte-specific cis-element". J. Biol. Chem. 271 (29): 17504–11. doi:10.1074/jbc.271.29.17504. PMID 8663392.
- Marsden MD, Collins JE, Greenwood MD; et al. (1997). "Cloning and transcriptional analysis of the promoter of the human type 2 desmocollin gene (DSC2)". Gene 186 (2): 237–47. doi:10.1016/S0378-1119(96)00715-9. PMID 9074502.
- Adams MJ, Reichel MB, King IA; et al. (1998). "Characterization of the regulatory regions in the human desmoglein genes encoding the pemphigus foliaceous and pemphigus vulgaris antigens". Biochem. J. 329. ( Pt 1): 165–74. PMC 1219028. PMID 9405290.
- Shirakata Y, Amagai M, Hanakawa Y; et al. (1998). "Lack of mucosal involvement in pemphigus foliaceus may be due to low expression of desmoglein 1". J. Invest. Dermatol. 110 (1): 76–8. doi:10.1046/j.1523-1747.1998.00085.x. PMID 9424092.
- Amagai M, Nishikawa T, Nousari HC; et al. (1998). "Antibodies against desmoglein 3 (pemphigus vulgaris antigen) are present in sera from patients with paraneoplastic pemphigus and cause acantholysis in vivo in neonatal mice". J. Clin. Invest. 102 (4): 775–82. doi:10.1172/JCI3647. PMC 508940. PMID 9710446.
- Ishikawa H, Li K, Tamai K; et al. (2001). "Cloning of the mouse desmoglein 3 gene (Dsg3): interspecies conservation within the cadherin superfamily". Exp. Dermatol. 9 (4): 229–39. doi:10.1034/j.1600-0625.2000.009004229.x. PMID 10949543.
- Czerwenka KF, Manavi M, Hosmann J; et al. (2001). "Comparative analysis of two-dimensional protein patterns in malignant and normal human breast tissue". Cancer Detect. Prev. 25 (3): 268–79. PMID 11425269.
- Weiske J, Schöneberg T, Schröder W; et al. (2001). "The fate of desmosomal proteins in apoptotic cells". J. Biol. Chem. 276 (44): 41175–81. doi:10.1074/jbc.M105769200. PMID 11500511.
- Andl CD, Stanley JR (2001). "Central role of the plakoglobin-binding domain for desmoglein 3 incorporation into desmosomes". J. Invest. Dermatol. 117 (5): 1068–74. doi:10.1046/j.0022-202x.2001.01528.x. PMID 11710914.
- Merritt AJ, Berika MY, Zhai W; et al. (2002). "Suprabasal desmoglein 3 expression in the epidermis of transgenic mice results in hyperproliferation and abnormal differentiation". Mol. Cell. Biol. 22 (16): 5846–58. doi:10.1128/MCB.22.16.5846-5858.2002. PMC 133994. PMID 12138195.
- Strausberg RL, Feingold EA, Grouse LH; et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
- Hanakawa Y, Amagai M, Shirakata Y; et al. (2003). "Differential effects of desmoglein 1 and desmoglein 3 on desmosome formation". J. Invest. Dermatol. 119 (6): 1231–6. doi:10.1046/j.1523-1747.2002.19648.x. PMID 12485422.
- Veldman C, Stauber A, Wassmuth R; et al. (2003). "Dichotomy of autoreactive Th1 and Th2 cell responses to desmoglein 3 in patients with pemphigus vulgaris (PV) and healthy carriers of PV-associated HLA class II alleles". J. Immunol. 170 (1): 635–42. doi:10.4049/jimmunol.170.1.635. PMID 12496453.
- Posthaus H, Dubois CM, Müller E (2003). "Novel insights into cadherin processing by subtilisin-like convertases". FEBS Lett. 536 (1-3): 203–8. doi:10.1016/S0014-5793(02)03897-8. PMID 12586364.
Membrane proteins: cell adhesion molecules
|
|
Calcium-independent |
IgSF CAM |
- N-CAM (Myelin protein zero)
- ICAM (1, 5)
- VCAM-1
- PE-CAM
- L1-CAM
- Nectin (PVRL1, PVRL2, PVRL3)
|
|
|
Calcium-dependent |
Cadherins |
Classical |
|
|
Desmosomal |
- Desmoglein (DSG1, DSG2, DSG3, DSG4)
- Desmocollin (DSC1, DSC2, DSC3)
|
|
Protocadherin |
|
|
Unconventional/ungrouped |
- T-cadherin
- CDH4
- CDH5
- CDH6
- CDH8
- CDH11
- CDH12
- CDH15
- CDH16
- CDH17
- CDH9
- CDH10
|
|
|
Selectins |
- E-selectin
- L-selectin
- P-selectin
|
|
Integrins |
- LFA-1 (CD11a+CD18)
- Integrin alphaXbeta2 (CD11c+CD18)
- Macrophage-1 antigen (CD11b+CD18)
- VLA-4 (CD49d+CD29)
- Glycoprotein IIb/IIIa (ITGA2B+ITGB3)
|
|
|
Other |
- Lymphocyte homing receptor: CD44
- L-selectin
- integrin (VLA-4, LFA-1)
- Carcinoembryonic antigen
- CD22
- CD24
- CD44
- CD146
- CD164
|
|
- See also
- cell membrane protein disorders
Index of cells
|
|
Description |
- Structure
- Organelles
- peroxisome
- cytoskeleton
- centrosome
- epithelia
- cilia
- mitochondria
- Membranes
- Membrane transport
- ion channels
- vesicular transport
- solute carrier
- ABC transporters
- ATPase
- oxidoreduction-driven
|
|
Disease |
- Structural
- peroxisome
- cytoskeleton
- cilia
- mitochondria
- nucleus
- scleroprotein
- Membrane
- channelopathy
- solute carrier
- ATPase
- ABC transporters
- other
- extracellular ligands
- cell surface receptors
- intracellular signalling
- Vesicular transport
- Pore-forming toxins
|
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UpToDate Contents
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English Journal
- Salivary Samples for the Diagnosis of Pemphigus vulgaris Using the BIOCHIP Approach: a Pilot Study.
- Russo I1, Saponeri A1, Michelotto A1, Alaibac M2.
- In vivo (Athens, Greece).In Vivo.2017 Jan 2;31(1):97-99.
- Pemphigus vulgaris (PV) is a rare autoimmune intraepithelial blistering skin disease characterized by the presence of circulating autoantibodies against desmoglein 3 (DSG3) and desmoglein 1 (DSG1), resulting in loss of the normal epithelial cell-to-cell adhesion, through a process called acantholysi
- PMID 28064226
- Successful monotherapy of pemphigus vegetans with minocycline and nicotinamide.
- von Köckritz A1, Ständer S1, Zeidler C1, Metze D1, Luger T1, Bonsmann G1.
- Journal of the European Academy of Dermatology and Venereology : JEADV.J Eur Acad Dermatol Venereol.2017 Jan;31(1):85-88. doi: 10.1111/jdv.13779. Epub 2016 Sep 7.
- BACKGROUND: Pemphigus vegetans is a rare variant of pemphigus vulgaris, accounting for 1-2% of all pemphigus diseases. Systemic corticosteroids are the therapy of first choice in combination with immunosuppressants as steroid-sparing agents.OBJECTIVE: To highlight the exceptional but successful use
- PMID 27600093
- Prospective studies on the routine use of a novel multivariant enzyme-linked immunosorbent assay for the diagnosis of autoimmune bullous diseases.
- van Beek N1, Dähnrich C2, Johannsen N2, Lemcke S3, Goletz S4, Hübner F1, Di Zenzo G5, Dmochowski M6, Drenovska K7, Geller S8, Horn M9, Kowalewski C10, Medenica L11, Murrell DF12, Patsatsi A13, Uzun S14, Vassileva S7, Zillikens D15, Schlumberger W2, Schmidt E16.
- Journal of the American Academy of Dermatology.J Am Acad Dermatol.2016 Dec 28. pii: S0190-9622(16)31043-X. doi: 10.1016/j.jaad.2016.11.002. [Epub ahead of print]
- BACKGROUND: Serologic diagnosis of autoimmune blistering disease (AIBD) usually follows a sophisticated multistep algorithm.OBJECTIVE: We sought validation of a multivariant enzyme-linked immunosorbent assay (ELISA) in the routine diagnosis of AIBD.METHODS: The multivariant ELISA comprising 6 recomb
- PMID 28038887
Japanese Journal
- デスモグレイン (広範囲 血液・尿化学検査 免疫学的検査(第7版・4)その数値をどう読むか) -- (可溶性膜蛋白,接着分子)
- 抗デスモグレイン1および3抗体,抗BP180(NC16a)抗体,抗BP230抗体 (広範囲 血液・尿化学検査 免疫学的検査(第7版・3)その数値をどう読むか) -- (免疫学的検査 自己抗体)
Related Links
- Desmoglein-3 Mouse monoclonal antibody クローン: 5G11 メーカー: Kamiya Biomedical (Cat. No. MC-214) 希釈倍率: ×2 抗原賦活化: CC1 (Ventana) 推奨陽性コントロール: 扁平上皮 染色パターン: 細胞膜 (上記は神戸大病理部で ...
- GoPubMed lists recent and important papers and reviews for desmoglein 3(Desmoglein 3) ... Desmosomes are cell-cell junctions between epithelial, myocardial, and certain other cell types. Desmoglein 3 is a calcium-binding ...
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