- 関
- derepress、disinhibit、disinhibition
Wikipedia preview
出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2015/06/02 13:27:07」(JST)
[Wiki en表示]
In genetics and biochemistry, a repressor gene inhibits the activity of an operator gene. Removal of repression, such as of an operon so that gene transcription occurs or is enhanced, with the net result frequently being elevation of the level of a specific enzyme. This effect is called derepression.
Derepression of ALA synthase
One example is the effect of drugs on the activity of ALA synthase, an enzyme involved in heme-synthesis. When inducing for example phenobarbital, griseofulvin or hydantoins, the activity of ALA synthase will rise. The cause is a production of cytochrome P450-production, induced by the drugs, consuming heme. When the amount of heme in the liver decreases, it no longer act as a repressor for its synthesis. On the contrary, ALA synthase increases which leads to an increase in heme-production.
References
- Pamela C., Ph.D. Champe, Richard A., Ph.D. Harvey, Denise R., Ph.D. Ferrier, (2004). Lippincott's Illustrated Reviews: Biochemistry 319 (3rd edition ed.). Hagerstown, MD: Lippincott Williams & Wilkins. ISBN 0-7817-2265-9.
- http://medical-dictionary.thefreedictionary.com/derepression
UpToDate Contents
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English Journal
- Effects of GLC7 and REG1 deletion on maltose metabolism and leavening ability of baker's yeast in lean dough.
- Lin X1, Zhang CY2, Bai XW1, Xiao DG3.
- Journal of biotechnology.J Biotechnol.2015 Sep 10;209:1-6. doi: 10.1016/j.jbiotec.2015.06.386. Epub 2015 Jun 11.
- Maltose metabolism and leavening ability of baker's yeast (Saccharomyces cerevisiae) in lean dough is negatively influenced by glucose repression. To improve maltose metabolism and leavening ability, it is necessary to alleviate glucose repression. In this study, we focus on the effects of regulator
- PMID 26073997
- Hairless Up-Regulates Tgf-β2 Expression via Down-Regulation of miR-31 in the Skin of "Hairpoor" (HrHp) Mice.
- Kim BK1, Yoon SK1.
- Journal of cellular physiology.J Cell Physiol.2015 Sep;230(9):2075-85. doi: 10.1002/jcp.24935.
- Hairless (HR) has been shown to regulate hair follicle (HF) morphogenesis and hair cycling. The Hr mutant hair loss mouse referred to as "hairpoor" (Hr(Hp)) displays overexpression of the HR protein through translational derepression. In this study, we found that 64 miRNAs were differentially expres
- PMID 25639665
- Multiple allosteric effectors control the affinity of DasR for its target sites.
- Tenconi E1, Urem M2, Świątek-Połatyńska MA2, Titgemeyer F3, Muller YA4, van Wezel GP2, Rigali S5.
- Biochemical and biophysical research communications.Biochem Biophys Res Commun.2015 Aug 14;464(1):324-9. doi: 10.1016/j.bbrc.2015.06.152. Epub 2015 Jun 26.
- The global transcriptional regulator DasR connects N-acetylglucosamine (GlcNAc) utilization to the onset of morphological and chemical differentiation in the model actinomycete Streptomyces coelicolor. Previous work revealed that glucosamine-6-phosphate (GlcN-6P) acts as an allosteric effector which
- PMID 26123391
Japanese Journal
- Molecular Characterization of Hap Complex Components Responsible for Methanol-Inducible Gene Expression in the Methylotrophic Yeast Candida boidinii.
- Wearing Red for Signaling: The Heme-Bach Axis in Heme Metabolism, Oxidative Stress Response and Iron Immunology
- BOB.1-positive Classical Hodgkin's Lymphoma Carries Hypermethylation of Its Promoter as Epigenetic Marker of Gene-silencing Memory
Related Links
- derepression de·re·pres·sion (dē'rĭ-prěsh'ən) n. The activation of an operator gene by the deactivation of a repressor gene.
- derepression /de·re·pres·sion/ (de″re-presh´un) removal of repression, such as of an operon so that gene transcription occurs or is enhanced, with the net result frequently being elevation of the level of a specific enzyme. de·re·pres·sion
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- derepress、derepression、disinhibition
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- derepression、disinhibition、derepress、disinhibit
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- derepression、disinhibit、disinhibition