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出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2014/02/13 11:05:51」(JST)

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Deoxyuridine is a compound and a nucleoside. It is similar in chemical structure to uridine, but without the 2'-hydroxyl group.

Idoxuridine and Trifluridine are variants of deoxyuridine used as antiviral drugs. They are similar enough to be incorporated as part of DNA replication, but they possess side groups on the uracil component (an iodine and a CF₃ group, respectively), that prevent base pairing.

This biochemistry article is a stub. You can help Wikipedia by expanding it.

English Journal

A new bioassay identifies proliferation ratios of fibroblasts and myofibroblasts.

Vaughan MB1, Odejimi TD, Morris TL, Sawalha D, Spencer CL.
Cell biology international.Cell Biol Int.2014 Aug;38(8):981-6. doi: 10.1002/cbin.10289. Epub 2014 May 6.
Myofibroblasts are resident cells of wound healing, contractures and fibroses; these tissues are often referred to as fibroproliferative. Whether myofibroblasts themselves proliferate is of interest. Since many in vitro cultures are heterogeneous, staining in situ is required to identify the myofibr
PMID 24764319

Depletion of Kupffer cells modulates ethanol-induced hepatocyte DNA synthesis in C57Bl/6 mice.

Owumi SE1, Corthals SM, Uwaifo AO, Kamendulis LM, Klaunig JE.
Environmental toxicology.Environ Toxicol.2014 Aug;29(8):867-75. doi: 10.1002/tox.21814. Epub 2012 Sep 20.
Kupffer cells (KCs) are important in hepatic homeostasis and responses to xenobiotics. KCs are activated on interaction with endotoxin, releasing cytokines, and reactive oxygen species normally associated with increased gene expression, cellular growth, or hepatic injury. Ethanol-induced endotoxemia
PMID 22996800

Effects of 5'-fluoro-2-deoxyuridine on mitochondrial biology in Caenorhabditis elegans.

Rooney JP1, Luz AL1, González-Hunt CP1, Bodhicharla R1, Ryde IT1, Anbalagan C1, Meyer JN2.
Experimental gerontology.Exp Gerontol.2014 Aug;56:69-76. doi: 10.1016/j.exger.2014.03.021. Epub 2014 Apr 3.
5-Fluoro-2'-deoxyuridine (FUdR) is a DNA synthesis inhibitor commonly used to sterilize Caenorhabditis elegans in order to maintain a synchronized aging population of nematodes, without contamination by their progeny, in lifespan experiments. All somatic cells in the adult nematode are post-mitotic
PMID 24704715

Japanese Journal

Identification of tympanic border cells as slow-cycling cells in the cochlea.

Taniguchi Mirei,Yamamoto Norio,Nakagawa Takayuki,Ogino Eriko,Ito Juichi
PloS one 7(10), 2012-10-31
… In this study, using the exogenous proliferation marker, 5'-bromo-2'-deoxyuridine (BrdU) in combination with the endogenous proliferation marker Ki-67, we identified tympanic border cells. …
NAID 120004945149

Luteolin Inhibits Angiotensin II-Induced Human Umbilical Vein Endothelial Cell Proliferation and Migration Through Downregulation of Src and Akt Phosphorylation

Zhu Manyi,Chen Dan,Li Dongye,Ding Hong,Zhang Tian,Xu Tongda,Zhang Yanbin
Circulation Journal, 2012
… Analysis using methyl thiazolyl tetrazolium and 5-ethynyl-2'-deoxyuridine revealed that 25μmol/L luteolin had a particularly inhibitory effect on the AngII-induced proliferation of HUVECs. …
NAID 130002491327

Neuroprotective Capabilities of Tanshinone IIA against Cerebral Ischemia/Reperfusion Injury via Anti-apoptotic Pathway in Rats

Chen Yanlin,Wu Xuemei,Yu Shanshan [他],Fauzee Nilufer Jasmine Selimah,Wu Jingxian,Li Lan,Zhao Jing,Zhao Yong
Biological and Pharmaceutical Bulletin 35(2), 164-170, 2012
… Fewer terminal deoxyribonucleotidyl transferase-mediated deoxyuridine triphosphate biotin nick-end labeling (TUNEL)-positive cells were found in the penumbra of the treated group, but they were significantly more common in the vehicle group. …
NAID 130001872289

「deoxyuridine monophosphate」

Deoxyuridine
Identifiers
CAS number	951-78-0
PubChem	640
ChemSpider	13118
UNII	W78I7AY22C
MeSH	Deoxyuridine
ChEBI	CHEBI:16450
ChEMBL	CHEMBL353955
Jmol-3D images	Image 1
	SMILES O=C/1NC(=O)N(\C=C\1)[C@@H]2O[C@@H]([C@@H](O)C2)CO ;
	InChI InChI=1S/C9H12N2O5/c12-4-6-5(13)3-8(16-6)11-2-1-7(14)10-9(11)15/h1-2,5-6,8,12-13H,3-4H2,(H,10,14,15)/t5-,6+,8+/m0/s1 ; Key: MXHRCPNRJAMMIM-SHYZEUOFSA-N InChI=1/C9H12N2O5/c12-4-6-5(13)3-8(16-6)11-2-1-7(14)10-9(11)15/h1-2,5-6,8,12-13H,3-4H2,(H,10,14,15)/t5-,6+,8+/m0/s1; Key: MXHRCPNRJAMMIM-SHYZEUOFBK ;
Properties
Molecular formula	C9H12N2O5
Molar mass	228.202
	(verify) (what is: /?); Except where noted otherwise, data are given for materials in their standard state (at 25 °C (77 °F), 100 kPa)
	Infobox references

　　[★]

デオキシウリジン一リン酸

関: dUMP

「bromodeoxyuridine」

　　[★] ブロモデオキシウリジン BrdU

「5-fluorodeoxyuridine」

　　[★] 5-フルオロデオキシウリジン

匿名

検索

案内

案内

deoxyuridine