デオキシリボヌクレオチド
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出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2014/09/25 20:01:02」(JST)
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A deoxyribonucleotide is the monomer, or single unit, of DNA, or deoxyribonucleic acid. Each deoxyribonucleotide comprises three parts: a nitrogenous base, a deoxyribose sugar, and one phosphate group.[1] The nitrogenous base is always bonded to the 1' carbon of the deoxyribose, which is distinguished from ribose by the presence of a proton on the 2' carbon rather than an -OH group. The phosphate groups bind to the 5' carbon of the sugar.
When deoxyribonucleotides polymerize to form DNA, the phosphate group from one nucleotide will bond to the 3' carbon on another nucleotide, forming a phosphodiester bond via dehydration synthesis. New nucleotides are always added to the 3' carbon of the last nucleotide, so synthesis always proceeds from 5' to 3'.
References
- ^ Coghill, Anne M.; Garson, Lorrin R., ed. (2006). The ACS style guide: effective communication of scientific information (3rd ed.). Washington, D.C.: American Chemical Society. p. 244. ISBN 978-0-8412-3999-9.
External links
- Deoxyribonucleotides at the US National Library of Medicine Medical Subject Headings (MeSH)
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Nucleic acid constituents
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| Nucleobase |
- Purine
- Adenine
- Guanine
- Hypoxanthine
- Xanthine
- Purine analogue
- Pyrimidine
- Uracil
- Thymine
- Cytosine
- Pyrimidine analogue
- Unnatural base pair (UBP)
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| Nucleoside |
| Ribonucleoside |
- Adenosine
- Guanosine
- 5-Methyluridine
- Uridine
- Cytidine
- Inosine
- Xanthosine
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| Deoxyribonucleoside |
- Deoxyadenosine
- Deoxyguanosine
- Thymidine
- Deoxyuridine
- Deoxycytidine
- Deoxyinosine
- Deoxyxanthosine
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Nucleotide
(Nucleoside monophosphate) |
| Ribonucleotide |
- AMP
- GMP
- m5UMP
- UMP
- CMP
- IMP
- XMP
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| Deoxyribonucleotide |
- dAMP
- dGMP
- dTMP
- dUMP
- dCMP
- dIMP
- dXMP
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| Cyclic nucleotide |
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| Nucleoside diphosphate |
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| Nucleoside triphosphate |
- ATP
- GTP
- m5UTP
- UTP
- CTP
- ITP
- XTP
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- dATP
- dGTP
- dTTP
- dUTP
- dCTP
- dITP
- dXTP
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- Biochemical families: carbohydrates
- alcohols
- glycoproteins
- glycosides
- lipids
- eicosanoids
- fatty acids / intermediates
- glycerides
- phospholipids
- sphingolipids
- steroids
- nucleic acids
- constituents / intermediates
- proteins
- Amino acids / intermediates
- tetrapyrroles / intermediates
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English Journal
- Genome-wide profiling of chemoradiation‑induced changes in alternative splicing in colon cancer cells.
- Xiong W1, Gao D2, Li Y3, Liu X4, Dai P1, Qin J1, Wang G2, Li K1, Bai H1, Li W1.
- Oncology reports.Oncol Rep.2016 Oct;36(4):2142-50. doi: 10.3892/or.2016.5022. Epub 2016 Aug 12.
- Alternative splicing is a key mechanism that regulates protein diversity and has been found to be associated with colon cancer progression and metastasis. However, the function of alternative splicing in chemoradiation‑resistant colon cancer remains elusive. In this study, we constructed a chemora
- PMID 27573869
- Electrical detection and quantification of single and mixed DNA nucleotides in suspension.
- Ahmad MA1,2, Panicker NG3, Rizvi TA2,4, Mustafa F2,3.
- Scientific reports.Sci Rep.2016 Sep 28;6:34016. doi: 10.1038/srep34016.
- High speed sequential identification of the building blocks of DNA, (deoxyribonucleotides or nucleotides for short) without labeling or processing in long reads of DNA is the need of the hour. This can be accomplished through exploiting their unique electrical properties. In this study, the four dif
- PMID 27677329
- RNA-DNA Chimeras in the Context of an RNA World Transition to an RNA/DNA World.
- Gavette JV1,2, Stoop M1,2, Hud NV3,2, Krishnamurthy R4,5.
- Angewandte Chemie (International ed. in English).Angew Chem Int Ed Engl.2016 Sep 21. doi: 10.1002/anie.201607919. [Epub ahead of print]
- The RNA world hypothesis posits that DNA and proteins were later inventions of early life, or the chemistry that gave rise to life. Most scenarios put forth for the emergence of DNA assume a clean separation of RNA and DNA polymer, and a smooth transition between RNA and DNA. However, based on the r
- PMID 27650222
Japanese Journal
- ミトコンドリアのデオキシリボヌクレオチドプールの酸化と細胞死 (第1土曜特集 ここまでわかった ミトコンドリア研究の新展開) -- (酸化ストレスと関連疾患)
- Solvent Extraction of DNA with a Hydrolysable Double-chain Surfactant
- Itoh Yoshihiro,Takahashi Ken,Uemura Yuichi
- SEPARATION SCIENCE AND TECHNOLOGY 44(2), 466-475, 2009
- … A cationic lipophilic surfactant with two hydrolysable groups, di(1-octadecyloxycarbonylmethyl)dimethylammonium chloride, was synthesized and solvent extraction of deoxyribonucleotide (DNA) into organic solution (isooctane/1-octanol) with it as an extractant was examined. …
- NAID 80020197252
- Facile assay of telomerase activity utilizing a DNA-detectable chemiluminogenic reagent.
- Tonooka Keiko,Kabashima Tsutomu,Shibata Takayuki [他],Tang Chenhong,Yu Zhiqiang,Kai Masaaki
- Analytical sciences : the international journal of the Japan Society for Analytical Chemistry 24(4), 471-475, 2008-04-10
- … The PCR products were separated from the excess substrate, primer and deoxyribonucleotide triphosphates by a centrifugal filter, which distinguished different molecular sizes. …
- NAID 10021099521
Related Links
- deoxyribonucleotide [de-ok″sĭ-ri″bo-noo´kle-o-tīd] a nucleotide having a purine or pyrimidine base bonded to deoxyribose, which in turn is bonded to a phosphate group. de·ox·y·ri·bo·nu·cle·o·tide (dē-oks'ē-rī'bō-nū'klē-ō-tīd), A nucleotide ...
- deoxyribonucleotide de·ox·y·ri·bo·nu·cle·o·tide (dē-ŏk'sē-rī'bō-nōō'klē-ə-tīd', -nyōō'-) n. A nucleotide containing deoxyribose that is a constituent of DNA.
★リンクテーブル★
[★]
- 英
- [[]]
- 同
- deoxyribonucleotide
- 関
- [[]]
- 同
- deoxyribonucleotide
[★]
オリゴデオキシリボヌクレオチド、オリゴDNA
- 関
- ODN、oligodeoxynucleotide
[★]
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