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1. 肺静脈閉塞性疾患 pulmonary veno occlusive disease
2. 造血細胞移植後の肝類洞閉塞症候群の治療および予防 treatment and prevention of hepatic sinusoidal obstruction syndrome following hematopoietic cell transplantation
3. 跛行の内科的管理 medical management of claudication

English Journal

Viscoelastic interactions between polydeoxyribonucleotide and ophthalmic excipients.

Kim I1, Kim H1, Park K1, Karki S1, Khadka P1, Jo K1, Kim SY1, Ro J1, Lee J1.
Drug development and industrial pharmacy.Drug Dev Ind Pharm.2016 Feb;42(2):231-7. doi: 10.3109/03639045.2015.1040417. Epub 2015 May 29.
This study investigated the interaction between polydeoxyribonucleotide (PDRN) and several ionic and nonionic isotonic agents, thickeners and a preservative that were employed as excipients in ophthalmic preparations. Interaction of each individual excipient and PDRN aqueous solution was evaluated b
PMID 26023993

Lee DW1, Hong HJ, Roh H, Lee WJ.
Annals of plastic surgery.Ann Plast Surg.2015 Jul;75(1):84-90. doi: 10.1097/SAP.0000000000000053.
Polydeoxyribonucleotide (PDRN) has multiple vascular actions such as angiogenesis and production of a vascular endothelial growth factor (VEGF) through the adenosine A2 receptor stimulation. We applied PDRN on the ischemic flap of rat back and investigated whether it enhances the skin flap survival.
PMID 25954843

Effectiveness of polydeoxyribonucleotide injection versus normal saline injection for treatment of chronic plantar fasciitis: a prospective randomised clinical trial.

Kim JK1, Chung JY.
International orthopaedics.Int Orthop.2015 Jul;39(7):1329-34. doi: 10.1007/s00264-015-2772-0. Epub 2015 Apr 29.
PURPOSE: Polydeoxyribonucleotide (PDRN) has been used for the treatment of chronic tendinosis. This prospective randomised study was conducted to evaluate the efficacy and complications of PDRN injection for treatment of plantar fasciitis.METHODS: Forty patients with a clinical diagnosis of plantar
PMID 25920599

Polydeoxyribonucleotide stimulates angiogenesis and wound healing in the genetically diabetic mouse

GALEANO Mariarosaria,BITTO Alessandra,ALTAVILLA Domenica,MINUTOLI Letteria,POLITO Francesca,CALO Margherita,LO CASCIO Patrizia,D'ALCONTRES Francesco Stagno,SQUADRITO Francesco
Wound repair and regeneration 16(2), 208-217, 2008-03-01
NAID 10031181456

川上周司,久保田健吾,井町寛之,原田秀樹,大橋晶良
環境工学研究論文集 43, 143-148, 2006
ポリデオキシリボヌクレオチドプローブとtwo-pass tyramide signal amplification-fluorescence <I>in situ</I>hybridization (two-pass TSA-FISH) 法を用いてメタン生成古細菌<I>Methanococcus vannielii</I>のmethyl coenzy …
NAID 130003949508

Polydeoxyribonucleotide (defibrotide) protects against post-ischemic behavioral, electroencephalographic and neuronal damage in the gerbil