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Spirodi(iminohydantoin) Products from Oxidation of 2'-Deoxyguanosine in the Presence of NH4Cl in Nucleoside and Oligodeoxynucleotide Contexts.

Fleming AM1, Armentrout EI, Zhu J, Muller JG, Burrows CJ.
The Journal of organic chemistry.J Org Chem.2015 Jan 7. [Epub ahead of print]
Upon oxidation of the heterocyclic ring in 2'-deoxyguanosine (dG), the initial electrophilic intermediate displays a wide range of reactivities with nucleophiles leading to many downstream products. In the present study, the product profiles were mapped when aqueous solutions of dG were allowed to r
PMID 25539403

Vivet-Boudou V1, Isel C2, El Safadi Y3, Smyth RP3, Laumond G4, Moog C4, Paillart JC3, Marquet R5.
The Journal of biological chemistry.J Biol Chem.2015 Jan 2;290(1):371-83. doi: 10.1074/jbc.M114.616383. Epub 2014 Nov 14.
Because of their high mutation rates, RNA viruses and retroviruses replicate close to the threshold of viability. Their existence as quasi-species has pioneered the concept of "lethal mutagenesis" that prompted us to synthesize pyrimidine nucleoside analogues with antiviral activity in cell culture
PMID 25398876

The role of the Mpv17 protein mutations of which cause mitochondrial DNA depletion syndrome (MDDS): lessons from homologs in different species.

Löllgen S, Weiher H.
Biological chemistry.Biol Chem.2015 Jan 1;396(1):13-25. doi: 10.1515/hsz-2014-0198.
Abstract Mitochondrial DNA depletion syndromes (MDDS) are severe pediatric diseases with diverse clinical manifestations. Gene mutations that underlie MDDS have been associated with alterations in the mitochondrial DNA (mtDNA) replication machinery or in mitochondrial deoxyribonucleoside triphosphat
PMID 25205723

Synthesis of a Complete Janus-type Guanosine-Cytosine Base and Its 2'-Deoxyribonucleoside

Cytotoxic Effect of Drosophila Deoxynucleoside Kinase Gene on Replicating Plasmid in HeLa Cells

Ito Mana,Suda Yusuke,Harashima Hideyoshi [他],Kamiya Hiroyuki
Biological & Pharmaceutical Bulletin 33(7), 1223-1227, 2010
… Surprisingly, the introduction of the replicating plasmid DNA containing the Drosophila melanogaster deoxyribonucleoside kinase (Dm-dNK) gene was highly cytotoxic and caused cell death without nucleoside analogs. …
NAID 130000300291

SUZUKI Shigeru,YAMAMOTO Takeshi,TOKUNAGA Etsuko,NAKAMURA Shuichi,TANAKA Motohiro,SASAKI Takuma,SHIBATA Norio
Chemistry letters 38(11), 1046-1047, 2009-11-05
NAID 10025547854