WordNet

(mechanics) the equal and opposite force that is produced when any force is applied to a body; "every action has an equal and opposite reaction"
a response that reveals a persons feelings or attitude; "he was pleased by the audiences reaction to his performance"; "John feared his mothers reaction when she saw the broken lamp"
a bodily process occurring due to the effect of some antecedent stimulus or agent; "a bad reaction to the medicine"; "his responses have slowed with age" (同)response
doing something in opposition to another way of doing it that you dont like; "his style of painting was a reaction against cubism"
an idea evoked by some experience; "his reaction to the news was to start planning what to do"
extreme conservatism in political or social matters; "the forces of reaction carried the election"
act later than planned, scheduled, or required; "Dont delay your application to graduate school or else it wont be considered"
time during which some action is awaited; "instant replay caused too long a delay"; "he ordered a hold in the action" (同)hold, time_lag, postponement, wait
the act of delaying; inactivity resulting in something being put off until a later time (同)holdup
cause to be slowed down or delayed; "Traffic was delayed by the bad weather"; "she delayed the work that she didnt want to perform" (同)detain, hold_up
characterized by or caused by allergy; "an allergic reaction"
having an allergy or peculiar or excessive susceptibility (especially to a specific factor); "allergic children"; "hypersensitive to pollen" (同)hypersensitive, hypersensitized, hypersensitised, sensitized, sensitised, supersensitive, supersensitized, supersensitised
not as far along as normal in development

PrepTutorEJDIC

{名}(…に対する)『反応』《+『to』+『名』》 / 〈U〉(…に対する)(政治的・社会的な)『反動』,逆コース《+『against』+『名』》 / 〈U〉〈C〉化学反応,化学変化 / 〈U〉〈C〉(物理学で)反作用
…'を'『延期する』,延ばす / 〈事故などが〉…'を'『遅らせる』 / 『ぐずぐずする』,『手間取る』 / 『遅れ』,遅延 / 『延期』,猶予
アレルギー性の;(…に)アレルギーを起こす《+『to』+『名』》 / 《補語にのみ用いて》《話》(…に)神経過敏の,(…が)大きらいの《+『to』+『名』(do『ing)』》

UpToDate Contents

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1. 薬物アレルギー：分類および臨床的特徴 drug allergy classification and clinical features
2. 薬物アレルギー患者へのアプローチ an approach to the patient with drug allergy
3. ペニシリンアレルギー：遅発型過敏反応 penicillin allergy delayed hypersensitivity reactions
4. 海産物アレルギー：魚介類 seafood allergies fish and shellfish
5. 予防接種に対するアレルギー反応 allergic reactions to vaccines

English Journal

Immunomodulatory activity of methanolic extract of Amorphophallus commutatus var. wayanadensis under normal and cyclophosphamide induced immunosuppressive conditions in mice models.

Raj S1, Gothandam KM2.
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association.Food Chem Toxicol.2015 Jul;81:151-9. doi: 10.1016/j.fct.2015.04.026. Epub 2015 Apr 24.
The present study investigates the immunomodulatory activity of methanolic extract of Amorphophallus commutatus var. wayanadensis (MEAC) under normal and cyclophosphamide induced immunosuppressive conditions in Swiss albino mice models. The splenocyte proliferation assay was performed to study in-vi
PMID 25916916

Increased frequency of delayed type hypersensitivity to metals in patients with connective tissue disease.

Stejskal V1, Reynolds T2, Bjørklund G3.
Journal of trace elements in medicine and biology : organ of the Society for Minerals and Trace Elements (GMS).J Trace Elem Med Biol.2015 Jul;31:230-6. doi: 10.1016/j.jtemb.2015.01.001. Epub 2015 Jan 14.
BACKGROUND: Connective tissue disease (CTD) is a group of inflammatory disorders of unknown aetiology. Patients with CTD often report hypersensitivity to nickel. We examined the frequency of delayed type hypersensitivity (DTH) (Type IV allergy) to metals in patients with CTD.METHODS: Thirty-eight pa
PMID 25636536

Amphiphilic Macromolecule Self-Assembled Monolayers Suppress Smooth Muscle Cell Proliferation.

Chan JW, Zhang Y, Uhrich KE.
Bioconjugate chemistry.Bioconjug Chem.2015 Jun 4. [Epub ahead of print]
A significant limitation of cardiovascular stents is restenosis, where excessive smooth muscle cell (SMC) proliferation following stent implantation causes blood vessel re-occlusion. While drug-eluting stents minimize SMC proliferation through releasing cytotoxic or immunosuppressive drugs from poly
PMID 26042535

Japanese Journal

Granulomatous Lymphadenitis

ASANO Shigeyuki
Journal of clinical and experimental hematopathology 52(1), 1-16, 2012-05-01
… Noninfectious GLA includes sarcoidosis and sarcoid-like reaction. … Sarcoid-like reaction, which is considered to be a biological defense mechanism, is observed in regional lymph nodes with many underlying diseases. … These are induced by delayed allergic reaction of <I>M</I>. …
NAID 10030615424

The Rhizomes of Alisma orientale and Alisol Derivatives Inhibit Allergic Response and Experimental Atopic Dermatitis

Lee Je Hyeong,Kwon Oh Song,Jin Hong-Guang,Woo Eun-Rhan,Kim Yeong Shik,Kim Hyun Pyo
Biological and Pharmaceutical Bulletin 35(9), 1581-1587, 2012
… It also attenuated delayed-type hypersensitivity (DTH) reaction in mice. … These results indicate that alisol derivatives possess inhibitory activities on immediate-type as well as delayed-type hypersensitivity reactions and may contribute to the anti-allergic action of AOE. …
NAID 130001872065

Inhibitory Effect of Acteoside Isolated from Cistanche tubulosa on Chemical Mediator Release and Inflammatory Cytokine Production by RBL-2H3 and KU812 Cells

Yamada Parida,Iijima Rieko,Han Junkyu,Shigemori Hideyuki,Yokota Shinichi,Isoda Hiroko,山田パリーダ,韓畯奎,繁森英幸,礒田博子
Planta medica 76(14), 1512-1518, 2010-10
… The immediate-type allergic reaction is involved in many allergic diseases such as asthma, allergic rhinitis, and sinusitis. … Wight on the basophilic cell-mediated allergic reaction. … Our findings provide evidence that acteoside inhibits basophilic cell-derived immediate-type and delayed-type allergic reactions. …
NAID 120003386773

「IV型アレルギー」

　　[★]

英: type IV allergic reaction
同: IV型アレルギー反応、type IV hypersensitivity、遅延型アレルギー反応 delayed allergic reaction delayed type allergic reaction、遅延型過敏症 delayed-type hypersensitivity delayed type hypersensitivity DTH、遅延型過敏症アレルギー、遅延型アレルギー、遅延型過敏性免疫反応、遅延型過敏反応
関: アレルギー

概念

抗原特異的T細胞によって起こる細胞性免疫反応

関与する細胞・物質

1.

1) 抗原提示細胞：マクロファージ、樹状細胞
2) 抗原に感作されたT細胞(IV型アレルギーの原因となっているT細胞 = T_DTH)

2. T細胞が放出するサイトカイン(昔の言葉でリンホカイン)
3. 2.によって動員される細胞：T細胞、マクロファージ

アレルギー反応発現までの時間

ピークは24-48hr　　⇔　I型アレルギーは即時

病態生理

体内に侵入した抗原は樹状細胞やマクロファージなどの抗原提示細胞に貪食され分解されて、MHC class IIに抗原をのせてT細胞に提示する。T細胞は感作され、再び抗原刺激を受けるとINF-γやTNF-αなどのサイトカインを産生し炎症を惹起する。この反応は抗原進入後48時間程度でピークとなる。(SPE.291)
ここで活性化されるT細胞がTh2細胞優位である場合、I型アレルギー反応の遅延型反応のような反応を呈する。