WordNet

lose specialization in form or function
the loss of specialization in form or function
having experienced or undergone dedifferentiation or the loss of specialization in form or function; "the hebephrenic--the most severely dedifferentiated of all schizophrenic patients"

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Massive rearrangements of cellular miRNA signatures are key drivers of hepatocyte dedifferentiation.

Lauschke VM1, Vorrink SU1, Moro SM1, Reyazee F1, Nordling Å1, Hendriks DF1, Bell CC1, Sison-Young R2, Park BK2, Goldring CE2, Ellis E3, Johansson I1, Mkrtchian S1, Andersson TB1,4, Ingelman-Sundberg M1.
Hepatology (Baltimore, Md.).Hepatology.2016 Aug 17. doi: 10.1002/hep.28780. [Epub ahead of print]
Hepatocytes are dynamic cells that upon injury can alternate between non-dividing differentiated and dedifferentiated proliferating states in vivo. However, in 2D cultures primary human hepatocytes rapidly dedifferentiate resulting in the loss of hepatic functions which significantly limits their us
PMID 27532775

Thyroid hormone activates Wnt/β-catenin signaling involved in adult epithelial development during intestinal remodeling in Xenopus laevis.

Hasebe T1, Fujimoto K1, Kajita M2, Ishizuya-Oka A3.
Cell and tissue research.Cell Tissue Res.2016 Aug;365(2):309-18. doi: 10.1007/s00441-016-2396-8. Epub 2016 Apr 11.
During amphibian intestinal remodeling, thyroid hormone (TH) induces some larval epithelial cells to dedifferentiate into adult stem cells, which newly generate the absorptive epithelium analogous to the mammalian epithelium. To clarify molecular mechanisms underlying adult epithelial development, w
PMID 27068920

Huch M1, Dollé L2.
Hepatology (Baltimore, Md.).Hepatology.2016 Aug;64(2):652-62. doi: 10.1002/hep.28469. Epub 2016 Mar 17.
Adult liver cells have been considered restricted regarding their fate and lineage potential. That is, hepatocytes have been thought able only to generate hepatocytes and duct cells, only duct cells. While this may be the case for the majority of scenarios in a state of quiescence or homeostasis, ev
PMID 26799921

ERK1/2 and AKT are vital factors in regulation of the migration of rat Schwann cells

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Journal of Veterinary Medical Science 77(4), 427-432, 2015
… During the process of degeneration, Schwann cells (SCs) dedifferentiate, proliferate and migrate to align in "bands of Büngner", providing structural guidance and growth-promoting substrates to regenerating axons. …
NAID 130005067026

ERK1/2 and AKT are vital factors in regulation of the migration of rat Schwann cells

, , , , , ,
Journal of Veterinary Medical Science advpub(0), 2015
… During the process of degeneration, Schwann cells (SCs) dedifferentiate, proliferate and migrate to align in "bands of Büngner", providing structural guidance and growth-promoting substrates to regenerating axons. …
NAID 130004781067

Time-lapse observation of the dedifferentiation process in mouse chondrocytes using chondrocyte-specific reporters

Minegishi Y.,Hosokawa K.,Tsumaki N.
Osteoarthritis and Cartilage 21, 1968-1975, 2013-12
… We also evaluated whether chondrocytes dedifferentiate because they proliferate or because they are cultured in monolayers.MethodsChondrocytes were prepared from Col11a2-EGFP transgenic mice and Col11a2-Cre; …
NAID 120005539508