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sarcoma of fat cells

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出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2016/04/19 18:14:04」(JST)

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Liposarcoma is a cancer that arises in fat cells in deep soft tissue, such as that inside the thigh or in the retroperitoneum.^[1] Liposarcoma is a rare type of cancer that bears a resemblance to fat cells when examined under a microscope.^[2]

They are typically large bulky tumors, and tend to have multiple smaller satellites that extend beyond the main confines of the tumor.

Liposarcomas, like all sarcomas, are rare.^[3]

Signs and symptoms

Left leg swelling caused by underlying liposarcoma

Patients usually note a deep seated mass in their soft tissue. Only when the tumor is very large do symptoms of pain or functional disturbances occur.

Retroperitoneal tumors may present themselves with signs of weight loss and emaciation and abdominal pain. These tumors may also compress the kidney or ureter leading to kidney failure.

Diagnosis

CT image showing a lesion that proved to be a liposarcoma.

The diagnosis is established by histologic examination of the tissue, i.e., biopsy or excision. Lipoblasts are often present; these are cells with an abundant clear multi-vacuolated cytoplasm and an eccentric darkly staining nucleus that is indented by the vacuoles.

Subtypes

Several subtypes of liposarcoma exist:

Well-differentiated liposarcoma, synonymous with atypical lipomatous tumor—the former term is used almost exclusively for lesions in the retroperitoneum, while the latter is used for lesions arising elsewhere
Dedifferentiated liposarcoma—well-differentiated (high-grade) liposarcoma adjacent to a more poorly differentiated tumor
Myxoid/round cell liposarcoma.
Pleomorphic liposarcoma.

Micrograph of a myxoid liposarcoma. H&E stain.
Micrograph of a dedifferentiated liposarcoma. H&E stain.

Prognosis

The prognosis varies depending on the site of origin, the type of cancer cell, the tumor size, the depth, and proximity to lymph nodes. Well-differentiated liposarcomas treated with surgery, intra-operative distilled water lavage^[4] and radiation have a low recurrence rate (about 10%) and rarely metastasize.^[5]

Five-year survival rates vary from 100% to 56% based on histological subtype.^[5]

Epidemiology

Most frequent in middle-aged and older adults (age 40 and above), liposarcomas are the second most common of all soft-tissue sarcomas following malignant fibrous histiocytomas. Annually 2.5 cases occur per million population.

Society and culture

Notable cases

Chad Brown (1961–2014), a poker player
Richard Feynman (1918–1988), a theoretical physicist died following surgery to address the disease
Rob Ford (1969–2016), former mayor of Toronto who died of pleomorphic liposarcoma
Hokie Gajan (1959–2016), former running back for the New Orleans Saints and radio color commentator for the team

Philanthropy

The Liposarcoma Genome Project at the Massachusetts General Hospital Cancer Center is currently researching liposarcoma to learn more about its genetic drivers and design effective new treatment options for patients.

The Wendy Walk is an organization devoted to funding research for liposarcoma.

References

^ Dei Tos AP (August 2000). "Liposarcoma: new entities and evolving concepts". Ann Diagn Pathol 4 (4): 252–66. doi:10.1053/adpa.2000.8133. PMID 10982304.
^ Bell, Teresa (October 2012). "What is Liposarcoma?". The Liddy Shriver Sarcoma Initiative. Retrieved 2015-04-22.
^ Goldstein-Rice, E (2008). "The Importance of Treatment at a Specialty Center for Sarcomas". ESUN.
^ Song CH, Chai FY, Saukani MFM, Singh H, Jiffre D (July 2013). "Management and Prevention of Recurrent Paratesticular Liposarcoma". Malays J Med Sci. 20 (4): 95–97. PMC: 3773360. PMID 24044004.
^ ^a ^b Gebhardt, M and Buecker, PJ (2004). "Liposarcoma". ESUN.

External links

humpath #2495 (Pathology images)
Information from The Doctor's Doctor website
Liposarcoma by Dr. Gebhardt and Dr. Buecker

UpToDate Contents

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1. 後腹膜軟部組織肉腫の臨床的特徴、評価、および治療 clinical features evaluation and treatment of retroperitoneal soft tissue sarcoma
2. 軟部組織肉腫の臨床所見、病理組織学的検査、診断的評価、および病期分類 clinical presentation histopathology diagnostic evaluation and staging of soft tissue sarcoma
3. 転移性軟部組織肉腫の全身治療 systemic treatment of metastatic soft tissue sarcoma
4. 四肢の軟部組織肉腫に対する補助化学療法および術前補助化学療法 adjuvant and neoadjuvant chemotherapy for soft tissue sarcoma of the extremities
5. 転移性軟部肉腫に対する外科治療およびその他の局所療法 surgical treatment and other localized therapy for metastatic soft tissue sarcoma

English Journal

Patterns of TPD52 overexpression in multiple human solid tumor types analyzed by quantitative PCR.

Tennstedt P1, Bölch C2, Strobel G2, Minner S2, Burkhardt L2, Grob T2, Masser S2, Sauter G2, Schlomm T1, Simon R2.Author information 1Martini-Clinic, Section for Translational Prostate Cancer Research, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.2Institute of Pathology, Section for Translational Prostate Cancer Research, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.AbstractTumor protein D52 (TPD52) is located at chromosome 8q21, a region that is frequently gained or amplified in multiple human cancer types. TPD52 has been suggested as a potential target for new anticancer therapies. In order to analyze TPD52 expression in the most prevalent human cancer types, we employed quantitative PCR to measure TPD52 mRNA levels in formalin-fixed tissue samples from more than 900 cancer tissues obtained from 29 different human cancer types. TPD52 was expressed at varying levels in all tested normal tissues, including skin, lymph node, lung, oral mucosa, breast, endometrium, ovary, vulva, myometrium, liver, pancreas, stomach, kidney, prostate, testis, urinary bladder, thyroid gland, brain, muscle and fat tissue. TPD52 was upregulated in 18/29 (62%) tested cancer types. Strongest expression was found in non-seminoma (56-fold overexpression compared to corresponding normal tissue), seminoma (42-fold), ductal (28-fold) and lobular breast cancer (14-fold). In these tumor types, TPD52 upregulation was found in the vast majority (>80%) of tested samples. Downregulation was found in 11 (38%) tumor types, most strongly in papillary renal cell cancer (-8-fold), leiomyosarcoma (-6-fold), clear cell renal cell cancer (-5-fold), liposarcoma (-5-fold) and lung cancer (-4-fold). These results demonstrate that TPD52 is frequently and strongly upregulated in many human cancer types, which may represent candidate tumor types for potential anti-TPD52 therapies.
International journal of oncology.Int J Oncol.2014 Feb;44(2):609-15. doi: 10.3892/ijo.2013.2200. Epub 2013 Nov 29.
Tumor protein D52 (TPD52) is located at chromosome 8q21, a region that is frequently gained or amplified in multiple human cancer types. TPD52 has been suggested as a potential target for new anticancer therapies. In order to analyze TPD52 expression in the most prevalent human cancer types, we empl
PMID 24317684

Myxoid liposarcoma of the spermatic cord: US and MR imaging findings.

Abete L, Simonato A, Toncini C, Carmignani G, Derchi LE.Author information Dipartimento Scienze Chirurgiche, Settore Anatomia Patologica, Università di Genova, Genova, Italy.AbstractWe report a patient with myxoid liposarcoma of the spermatic cord in whom combined use of both ultrasound (US) and MRI helped to suggest the diagnosis. The lesion was solid at US and vascularized at color Doppler. T1-weighted MRI did not show fat within it; on T2-weighted images it had high signal intensity, with a cyst-like appearance. It is known that fat-poor myxoid liposarcomas with high water content may mimic a cystic lesion on non-contrast-enhanced MR; then, a combination of MRI findings, suggesting a cyst, and of US findings, showing the mass was actually solid and vascularized, allowed preoperatively the diagnosis of fat-poor myxoid liposarcoma. © 2013 Wiley Periodicals, Inc. J Clin Ultrasound 42:96-99, 2014.
Journal of clinical ultrasound : JCU.J Clin Ultrasound.2014 Feb;42(2):96-9. doi: 10.1002/jcu.22068. Epub 2013 Jul 17.
We report a patient with myxoid liposarcoma of the spermatic cord in whom combined use of both ultrasound (US) and MRI helped to suggest the diagnosis. The lesion was solid at US and vascularized at color Doppler. T1-weighted MRI did not show fat within it; on T2-weighted images it had high signal i
PMID 23861011

Challenging epithelioid mesenchymal neoplasms: mimics and traps.

Cacciatore M, Dei Tos AP.Author information Departments of Oncology and Pathology, Treviso, Italy.AbstractSUMMARY: Epithelioid mesenchymal malignancies represent a major diagnostic challenge. Epithelioid morphology can be observed in a variety of soft tissue neoplasms, however there exist specific subtypes in which an epithelioid apperance constitutes the most distinctive morphological feature. Moving from epithelioid sarcoma of Enzinger (the prototype of sarcoma with epithelioid morphology), this review will focus on the most relevant entities: namely epithelioid haemangioendothelioma and angiosarcoma, pseudomyogenic haemangioendothelioma, epithelioid malignant peripheral nerve sheath tumour, epithelioid sclerosing fibrosarcoma, epithelioid pleomorphic liposarcoma, alveolar soft part sarcoma, and undifferentiated soft tissue sarcoma with epithelioid morphology. Differential diagnoses and major pitfalls will be discussed in detail.
Pathology.Pathology.2014 Feb;46(2):126-34. doi: 10.1097/PAT.0000000000000063.
SUMMARY: Epithelioid mesenchymal malignancies represent a major diagnostic challenge. Epithelioid morphology can be observed in a variety of soft tissue neoplasms, however there exist specific subtypes in which an epithelioid apperance constitutes the most distinctive morphological feature. Moving f
PMID 24384587

Japanese Journal

症例 Bochdalek孔ヘルニアと鑑別を要した横隔膜脂肪腫の1例

直海晃,親松裕典,成田久仁夫 [他]
胸部外科 = The Japanese journal of thoracic surgery 67(10), 942-945, 2014-09
NAID 40020188581

脂肪芽細胞 : 形態学的特徴と診断学的価値

久岡正典
産業医科大学雑誌 36(2), 115-121, 2014-06-01
脂肪芽細胞は概念的に脂肪細胞の前駆的細胞ないし未成熟な細胞であり,組織学的には脂質を含んだ単ないし多空胞状の細胞質と陥凹し,しばしば帆立貝様の濃染性核を持つことを特徴とする.主として腫瘍性疾患において見られるが,前脂肪細胞のように正常脂肪組織の分化過程をある程度再現する細胞とみなされている.伝統的にその存在は特に脂肪肉腫の診断において強調されてきたが,Lochkern細胞や褐色脂肪,偽脂肪芽細胞な …
NAID 110009823330

急速に増大した後腹膜脂肪肉腫の1例

井出健弘,柳原豊,浅井聖史 [他]
西日本泌尿器科 = The Nishinihon journal of urology 76(4), 132-136, 2014-04
NAID 40020042077

Related Pictures

Liposarcoma | Primary Care Dermatology Pleomorphic Liposarcoma Retroperitoneal Liposarcoma Myxoid liposarcoma | Dermpedia Description Myxoid liposarcoma (05).JPG 18> Images For - Liposarcoma Arm Liposarcoma prognosis treatment Myxoid Liposarcoma | Andrew Comden's Blog

★リンクテーブル★

リンク元	「脂肪肉腫」
拡張検索	「dedifferentiated liposarcoma」

「脂肪肉腫」

Liposarcoma
	Micrograph of myxoid liposarcoma. H&E stain.
Classification and external resources
Specialty	Oncology
ICD-O	M8850/3
DiseasesDB	31482
eMedicine	derm/856
MeSH	D008080
	[edit on Wikidata]

　　[★]

英: liposarcoma
同: 脂肪形成肉腫 lipoplastic sarcoma

「dedifferentiated liposarcoma」

　　[★]

脱分化型脂肪肉腫

関: liposarcoma

[pmid10982304-1] Dei Tos AP (August 2000). "Liposarcoma: new entities and evolving concepts". Ann Diagn Pathol 4 (4): 252–66. doi:10.1053/adpa.2000.8133. PMID 10982304.

[2] Bell, Teresa (October 2012). "What is Liposarcoma?". The Liddy Shriver Sarcoma Initiative. Retrieved 2015-04-22.

[centers-3] Goldstein-Rice, E (2008). "The Importance of Treatment at a Specialty Center for Sarcomas". ESUN.

[PMC3773360-4] Song CH, Chai FY, Saukani MFM, Singh H, Jiffre D (July 2013). "Management and Prevention of Recurrent Paratesticular Liposarcoma". Malays J Med Sci. 20 (4): 95–97. PMC: 3773360. PMID 24044004.

[liposarcoma-5] Gebhardt, M and Buecker, PJ (2004). "Liposarcoma". ESUN.

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案内

案内

liposarcoma