同: deoxyribonucleoside triphosphate

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出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2013/09/20 11:17:30」(JST)

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A deoxyribonucleotide is the monomer, or single unit, of DNA, or deoxyribonucleic acid. Each deoxyribonucleotide comprises three parts: a nitrogenous base, a deoxyribose sugar, and one phosphate group.^[1] The nitrogenous base is always bonded to the 1' carbon of the deoxyribose, which is distinguished from ribose by the presence of a proton on the 2' carbon rather than an -OH group. The phosphate groups bind to the 5' carbon of the sugar.

When deoxyribonucleotides polymerize to form DNA, the phosphate group from one nucleotide will bond to the 3' carbon on another nucleotide, forming a phosphodiester bond via dehydration synthesis. New nucleotides are always added to the 3' carbon of the last nucleotide, so synthesis always proceeds from 5' to 3'.

References[edit source | edit]

^ Coghill, Anne M.; Garson, Lorrin R., ed. (2006). The ACS style guide: effective communication of scientific information (3rd ed.). Washington, D.C.: American Chemical Society. p. 244. ISBN 978-0-8412-3999-9.

External links[edit source | edit]

Deoxyribonucleotides at the US National Library of Medicine Medical Subject Headings (MeSH)

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1. 毛細血管拡張性運動失調症 ataxia telangiectasia

English Journal

Small Molecule Inhibition of SAMHD1 dNTPase by Tetramer Destabilization.

Seamon KJ1, Hansen EC, Kadina AP, Kashemirov BA, McKenna CE, Bumpus NN, Stivers JT.
Journal of the American Chemical Society.J Am Chem Soc.2014 Jul 8. [Epub ahead of print]
SAMHD1 is a GTP-activated nonspecific dNTP triphosphohydrolase that depletes dNTP pools in resting CD4+ T cells and macrophages and effectively restricts infection by HIV-1. We have designed a nonsubstrate dUTP analogue with a methylene bridge connecting the α phosphate and 5' carbon that potently
PMID 24983818

Atypical Aicardi-Goutieres syndrome: Is the WRN locus a modifier?

Lessel D1, Saha B, Hisama F, Kaymakamzade B, Nurlu G, Gursoy-Özdemir Y, Thiele H, Nürnberg P, Martin GM, Kubisch C, Oshima J.
American journal of medical genetics. Part A.Am J Med Genet A.2014 Jul 2. doi: 10.1002/ajmg.a.36664. [Epub ahead of print]
We describe a 28-year-old Turkish man with consanguineous parents who presented with an aged appearance with prematurely gray hair and scleroderma-like skin, spastic paraplegia, and apparent disability. The proband and each of his parents were heterozygous for a mutation in WRN, which could not expl
PMID 24989684

Reciprocal regulation of autophagy and dNTP pools in human cancer cells.

Chen W1, Zhang L2, Zhang K3, Zhou B3, Kuo ML3, Hu S3, Chen L3, Tang M3, Chen YR3, Yang L3, Ann DK3, Yen Y4.
Autophagy.Autophagy.2014 Jul 1;10(7):1272-84. doi: 10.4161/auto.28954. Epub 2014 May 16.
Ribonucleotide reductase (RNR) plays a critical role in catalyzing the biosynthesis and maintaining the intracellular concentration of 4 deoxyribonucleoside triphosphates (dNTPs). Unbalanced or deficient dNTP pools cause serious genotoxic consequences. Autophagy is the process by which cytoplasmic c
PMID 24905824

Japanese Journal

Quick replication fork stop by overproduction of Escherichia coli DinB produces non-proliferative cells with an aberrant chromosome

Ikeda Mio,Shinozaki Yutaka,Uchida Kaori [他],OHSHIKA Yasuha,FURUKOHRI Asako,MAKI Hisaji,AKIYAMA TATSUMI Masahiro
Genes & genetic systems 87(4), 221-231, 2012-08-25
… Here, we show that the reduced colony-forming ability in the dinB-overexpressing cells is independent of the specific toxin genes that trigger programmed bacterial cell death when replication is blocked by depletion of the dNTP pool. …
NAID 10031126615

Mechanisms of dNTP supply that play an essential role in maintaining genome integrity in eukaryotic cells

NIIDA Hiroyuki,SHIMADA Midori,MURAKAMI Hiroshi,NAKANISHI Makoto
Cancer science 101(12), 2505-2509, 2010-12-10
NAID 10027834110

Silencing of the p53R2 gene by RNA interference inhibits growth and enhances 5-fluorouracil sensitivity of oral cancer cells

Yanamoto Souichi,Iwamoto Tsutomu,Kawasaki Goro,Yoshitomi Izumi,Baba Nobuyuki,Mizuno Akio
Cancer Letters 223(1), 67-76, 2005-06-01
… The p53R2 gene product causes an increase in the deoxynucleotide triphosphate (dNTP) pool in the nucleus, which facilitates DNA repair and synthesis. …
NAID 120000915750

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