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出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2016/01/18 11:50:09」(JST)
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| dCMP deaminase |
| Identifiers |
| EC number |
3.5.4.12 |
| CAS number |
9026-92-0 |
| Databases |
| IntEnz |
IntEnz view |
| BRENDA |
BRENDA entry |
| ExPASy |
NiceZyme view |
| KEGG |
KEGG entry |
| MetaCyc |
metabolic pathway |
| PRIAM |
profile |
| PDB structures |
RCSB PDB PDBe PDBsum |
| Gene Ontology |
AmiGO / EGO |
| Search |
| PMC |
articles |
| PubMed |
articles |
| NCBI |
proteins |
|
| dCMP deaminase |
| Identifiers |
| Symbol |
DCTD |
| Entrez |
1635 |
| HUGO |
2710 |
| OMIM |
607638 |
| RefSeq |
NM_001921 |
| UniProt |
P32321 |
| Other data |
| EC number |
3.5.4.12 |
| Locus |
Chr. 4 q35.1 |
dCMP deaminase (EC 3.5.4.12, deoxycytidylate deaminase, deoxy-CMP-deaminase, deoxycytidylate aminohydrolase, deoxycytidine monophosphate deaminase, deoxycytidine-5'-phosphate deaminase, deoxycytidine-5'-monophosphate aminohydrolase) is an enzyme which converts deoxycytidylic acid to deoxyuridylic acid.[1][2][3]
-
Deoxycytidine monophosphate
-
Deoxyuridine monophosphate
References
- ^ Scarano, E. (1960). "The enzymatic deamination of 6-aminopyrimidine deoxyribonucleotides. I. The enzymatic deamination of deoxycytidine 5′-phosphate and of 5-methyldeoxycytidine 5-methyldeoxycytidine 5′-phosphate". J. Biol. Chem. 235: 706–713. PMID 14442222.
- ^ Scarano, E., Bonaduce, L. and de Petrocellis, B. (1960). "The enzymatic deamination of 6-aminopyrimidine deoxyribonucleotides. II. Purification and properties of a 6-aminopyrimidine deoxyribonucleoside 5′-phosphate deaminase from unfertilized eggs of sea urchin". J. Biol. Chem. 235: 3556–3561. PMID 13747062.
- ^ Sergott, R.C., Debeer, L.J. and Bessman, M.J. (1971). "On the regulation of a bacterial deoxycytidylate deaminase". J. Biol. Chem. 246: 7755–7758. PMID 5002683.
External links
- dCMP deaminase at the US National Library of Medicine Medical Subject Headings (MeSH)
|
Hydrolases: carbon-nitrogen non-peptide (EC 3.5)
|
|
3.5.1: Linear amides /
Amidohydrolases |
- Asparaginase
- Glutaminase
- Urease
- Biotinidase
- Aspartoacylase
- Ceramidase
- Aspartylglucosaminidase
- Fatty acid amide hydrolase
- Histone deacetylase
|
|
3.5.2: Cyclic amides/
Amidohydrolases |
- Barbiturase
- Beta-lactamase
|
|
3.5.3: Linear amidines/
Ureohydrolases |
- Arginase
- Agmatinase
- Protein-arginine deiminase
|
|
3.5.4: Cyclic amidines/
Aminohydrolases |
- Guanine deaminase
- Adenosine deaminase
- AMP deaminase
- Inosine monophosphate synthase
- DCMP deaminase
- GTP cyclohydrolase I
- Cytidine deaminase
- AICDA
- Activation-induced cytidine deaminase
|
|
3.5.5: Nitriles/
Aminohydrolases |
|
|
| 3.5.99: Other |
- Riboflavinase
- Thiaminase II
|
|
- Biochemistry overview
- Enzymes overview
- By EC number: 1.1
- 2
- 3
- 4
- 5
- 6
- 7
- 8
- 9
- 10
- 11
- 12
- 13
- 14
- 15-99
- 2.1
- 3.1
- 4.1
- 5.1
- 6.1-3
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|
|
|
- Metabolism: amino acid metabolism
- nucleotide enzymes
|
|
| Purine metabolism |
| Anabolism |
| R5P→IMP: |
- Ribose-phosphate diphosphokinase
- Amidophosphoribosyltransferase
- Phosphoribosylglycinamide formyltransferase
- AIR synthetase (FGAM cyclase)
- Phosphoribosylaminoimidazole carboxylase
- Phosphoribosylaminoimidazolesuccinocarboxamide synthase
- IMP synthase
|
|
| IMP→AMP: |
- Adenylosuccinate synthase
- Adenylosuccinate lyase
- reverse
|
|
| IMP→GMP: |
- IMP dehydrogenase
- GMP synthase
- reverse
|
|
|
| Nucleotide salvage |
- Hypoxanthine-guanine phosphoribosyltransferase
- Adenine phosphoribosyltransferase
|
|
| Catabolism |
- Adenosine deaminase
- Purine nucleoside phosphorylase
- Guanine deaminase
- Xanthine oxidase
- Urate oxidase
|
|
|
| Pyrimidine metabolism |
| Anabolism |
- CAD
- Carbamoyl phosphate synthase II
- Aspartate carbamoyltransferase
- Dihydroorotase
|
|
- Dihydroorotate dehydrogenase
- Orotidine 5'-phosphate decarboxylase/Uridine monophosphate synthetase
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|
|
|
|
|
| Catabolism |
- Dihydropyrimidine dehydrogenase
- Dihydropyrimidinase/DPYS
- Beta-ureidopropionase/UPB1
|
|
|
| Deoxyribonucleotides |
- Ribonucleotide reductase
- Nucleoside-diphosphate kinase
- DCMP deaminase
- Thymidylate synthase
- Dihydrofolate reductase
|
|
|
Index of inborn errors of metabolism
|
|
| Description |
- Metabolism
- Enzymes and pathways: citric acid cycle
- pentose phosphate
- glycoproteins
- glycosaminoglycans
- phospholipid
- cholesterol and steroid
- sphingolipids
- eicosanoids
- amino acid
- urea cycle
- nucleotide
|
|
| Disorders |
- Citric acid cycle and electron transport chain
- Glycoprotein
- Proteoglycan
- Fatty-acid
- Phospholipid
- Cholesterol and steroid
- Eicosanoid
- Amino acid
- Purine-pyrimidine
- Heme metabolism
- Symptoms and signs
|
|
| Treatment |
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|
UpToDate Contents
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English Journal
- The First Crystal Structure of a dTTP Bound Deoxycytidylate Deaminase Validates and Details the Allosteric-Inhibitor Binding Site.
- Marx A1, Alian A2.
- The Journal of biological chemistry.J Biol Chem.2014 Nov 17. pii: jbc.M114.617720. [Epub ahead of print]
- Deoxycytidylate deaminase is unique within the zinc dependent cytidine deaminase family as being allosterically regulated; activated by dCTP and inhibited by dTTP. Here we present the first crystal structure of a dTTP bound deoxycytidylate deaminase from the bacteriophage S-TIM5, confirming that thi
- PMID 25404739
- STRIPE2 Encodes a Putative dCMP Deaminase that Plays an Important Role in Chloroplast Development in Rice.
- Xu J1, Deng Y1, Li Q1, Zhu X2, He Z3.
- Journal of genetics and genomics = Yi chuan xue bao.J Genet Genomics.2014 Oct 20;41(10):539-48. doi: 10.1016/j.jgg.2014.05.008. Epub 2014 Jun 19.
- Mutants with abnormal leaf coloration are good genetic materials for understanding the mechanism of chloroplast development and chlorophyll biosynthesis. In this study, a rice mutant st2 (stripe2) with stripe leaves was identified from the γ-ray irradiated mutant pool. The st2 mutant exhibited decr
- PMID 25438698
- Pyrimidine requirements in deoxyuridine triphosphate nucleotidohydrolase deficient Trypanosoma brucei mutants.
- Castillo-Acosta VM1, Aguilar-Pereyra F, García-Caballero D, Vidal AE, Ruiz-Pérez LM, González-Pacanowska D.
- Molecular and biochemical parasitology.Mol Biochem Parasitol.2013 Jan;187(1):9-13. doi: 10.1016/j.molbiopara.2012.11.003. Epub 2012 Nov 29.
- Trypanosomal all-alpha dUTPases are homodimeric enzymes that catalyze the hydrolysis of dUTP and dUDP to dUMP and PPi. Trypanosomes lack dCTP/dCMP deaminase and therefore strongly depend on dUDP/dUTP hydrolysis for dUMP production. Here we have addressed by gene replacement the consequences of elimi
- PMID 23201394
Japanese Journal
- 急性非リンパ性白血病のベヘノイル‐アラ‐Ｃ，アクラシノマイシンＡ，６ＭＰおよびプレドニソロンの４薬剤併用療法の試み
- 平野 正美,森下 剛久,井野 晶夫,松井 俊和,清水 鈴昭,重村 はるひ,中村 康一,小野 芳孝,斉藤 稔
- 臨床血液 22(3), 299-305, 1981
- … N4-behenoyl-1-β-D arabinofuranosylcytosine (BH-AC) is a newly synthesized derivative of cytosine arabinoside which is resistant to cytidine deaminase and is remarkably dose-independent in its antileukemia L 1210 effect. … It is to note that a complete remission was attained in two of three patients who had been resistant to DCMP therapy. …
- NAID 130004498325
Related Links
- DCMP Deaminase (n.) 1. (MeSH) An enzyme that catalyzes the hydrolytic deamination of deoxycytidylic acid to deoxyuridylic acid and ammonia. It plays an important role in the regulation of the pool of deoxynucleotides in higher ...
- Definition of dcmp deaminase in the Definitions.net dictionary. Meaning of dcmp deaminase. What does dcmp deaminase mean? Information and translations of dcmp deaminase in the most comprehensive dictionary definitions ...
★リンクテーブル★
[★]
- 関
- deoxycytidine monophosphate
[★]
- 関
- CdR、deoxycytidine
[★]
デアミナーゼ、脱アミノ酵素