cytidylic acid

• シチジル酸

関

CMP、cytidine monophosphate

WordNet

1. street name for lysergic acid diethylamide (同)back breaker, battery-acid, dose, dot, Elvis, loony toons, Lucy in the sky with diamonds, pane, superman, window pane, Zen
2. any of various water-soluble compounds having a sour taste and capable of turning litmus red and reacting with a base to form a salt
3. having the characteristics of an acid; "an acid reaction"

PrepTutorEJDIC

1. 酸性の / 酸味のある,すっぱい(sour) / (言葉・態度などが)厳しい,しんらつな / 酸 / すっぱいもの / 《俗》=LSD

Wikipedia preview

出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2012/10/15 13:36:16」(JST)

wiki en

[Wiki en表示]

Cytidine monophosphate
Other names 5'-Cytidylic acid
Identifiers
CAS number	63-37-6 Y
PubChem	6131
ChemSpider	5901 Y
ChEBI	CHEBI:17361 Y
ChEMBL	CHEMBL307679 Y
Jmol-3D images	Image 1
SMILES c1cn(c(=O)nc1N)[C@H]2[C@@H]([C@@H]([C@H](O2)COP(=O)(O)O)O)O
InChI InChI=1S/C9H14N3O8P/c10-5-1-2-12(9(15)11-5)8-7(14)6(13)4(20-8)3-19-21(16,17)18/h1-2,4,6-8,13-14H,3H2,(H2,10,11,15)(H2,16,17,18)/t4-,6-,7-,8-/m1/s1 Y Key: IERHLVCPSMICTF-XVFCMESISA-N Y InChI=1/C9H14N3O8P/c10-5-1-2-12(9(15)11-5)8-7(14)6(13)4(20-8)3-19-21(16,17)18/h1-2,4,6-8,13-14H,3H2,(H2,10,11,15)(H2,16,17,18)/t4-,6-,7-,8-/m1/s1 Key: IERHLVCPSMICTF-XVFCMESIBY
Properties
Molecular formula	C9H14N3O8P
Molar mass	323.20 g/mol
Acidity (pKa)	0.8, 4.5, 6.3
Y (verify) (what is: Y/N?) Except where noted otherwise, data are given for materials in their standard state (at 25 °C, 100 kPa)
Infobox references

Cytidine monophosphate, also known as 5'-cytidylic acid or simply cytidylate, and abbreviated CMP, is a nucleotide that is used as a monomer in RNA. It is an ester of phosphoric acid with the nucleoside cytidine. CMP consists of the phosphate group, the pentose sugar ribose, and the nucleobase cytosine; hence, a ribonucleoside monophosphate. As a substituent it takes the form of the prefix cytidylyl-.

Metabolism

CMP can be phosphorylated to Cytidine diphosphate by the enzyme CMP kinase, with Adenosine triphosphate or guanine triphosphate donating the phosphate group. Since Cytidine triphosphate is generated by amination of uridine triphosphate, the main source of CMP is from RNA being decomposed, e.g. by RNAse.

Biochemistry

CMP is used to activate mannose in metabolism.

See also

• Nucleoside
• Nucleotide
• DNA
• RNA
• Oligonucleotide
• Ribonucleoside monophosphate

References

UpToDate Contents

全文を閲覧するには購読必要です。 To read the full text you will need to subscribe.

• 1. 胎児の酸塩基の生理学 fetal acid base physiology
• 2. バルプロ酸中毒 valproic acid poisoning
• 3. 胃酸分泌の生理学 physiology of gastric acid secretion
• 4. 非酸性逆流の臨床的意義 clinical importance of non acid reflux
• 5. 尿酸による腎疾患 uric acid renal diseases

English Journal

• Ribonucleotide incorporation by human DNA polymerase η impacts translesion synthesis and RNase H2 activity.

• Mentegari E1, Crespan E1, Bavagnoli L1, Kissova M1, Bertoletti F1, Sabbioneda S1, Imhof R2, Sturla SJ3, Nilforoushan A3, Hübscher U2, van Loon B2, Maga G4.
• Nucleic acids research.Nucleic Acids Res.2016 Dec 19. pii: gkw1275. [Epub ahead of print]
• Ribonucleotides (rNs) incorporated in the genome by DNA polymerases (Pols) are removed by RNase H2. Cytidine and guanosine preferentially accumulate over the other rNs. Here we show that human Pol η can incorporate cytidine monophosphate (rCMP) opposite guanine, 8-oxo-7,8-dihydroguanine, 8-methyl-2
• PMID 27994034

• Silica-supported polymeric monolithic column with a mixed mode of hydrophilic and strong cation-exchange interactions for microcolumn liquid chromatography.

• Ren H1, Zhang X1, Li Z1, Liu Z1, Li J1.
• Journal of separation science.J Sep Sci.2016 Dec 8. doi: 10.1002/jssc.201601035. [Epub ahead of print]
• A novel sulfonic acid group containing hydrophilic strong cation-exchange monolith was prepared by in situ coating 5 μm bare silica particles with the copolymers of glycidyl methacrylate and pentaerythritol triacrylate and further sulfonating the prepared polymer matrix with Na2 SO3 inside a 150 μ
• PMID 27928885

• A Trojan-Horse Peptide-Carboxymethyl-Cytidine Antibiotic from Bacillus amyloliquefaciens.

• Serebryakova M1,2, Tsibulskaya D1, Mokina O1,3, Kulikovsky A1,3, Nautiyal M4, Van Aerschot A4, Severinov K1,3,5, Dubiley S1,3.
• Journal of the American Chemical Society.J Am Chem Soc.2016 Dec 7;138(48):15690-15698. Epub 2016 Nov 29.
• Microcin C and related antibiotics are Trojan-horse peptide-adenylates. The peptide part is responsible for facilitated transport inside the sensitive cell, where it gets processed to release a toxic warhead-a nonhydrolyzable aspartyl-adenylate, which inhibits aspartyl-tRNA synthetase. Adenylation o
• PMID 27934031

Japanese Journal

• Structural Analysis of β-1,3-D-Glucan-Polynucleotide Complex by MOPAC Calculation

• アジア・太平洋化学工学会議発表論文要旨集 2004(0), 421-421, 2004
• NAID 130005052465

• Enzymatic Properties of Double Mutant Enzymes at Asp51 and Trp49 and Asp51 and Tyr57 of RNase Rh from Rhizopus niveus

• Bioscience, biotechnology, and biochemistry 61(11), 1913-1918, 1997-11-23
• NAID 110002678843

• Electro-Optical and Hydrodynamic Properties of Synthetic Polyribonucleotides in Solutions as Studied by Electric Birefringence.

• Bulletin of the Chemical Society of Japan 68(2), 481-492, 1995
• NAID 130004057843

---

★リンクテーブル★

リンク元	「シチジル酸」「CMP」

「シチジル酸」

　　[★]

英

cytidylate, cytidylic acid

関

シチジン、シチジン一リン酸

「CMP」

　　[★]

• シチジン一リン酸

関

cytidine monophosphate、cytidylic acid