シスタチオニンγ-リアーゼ
WordNet
- a unit of magnetic field strength equal to one-hundred-thousandth of an oersted
- the 3rd letter of the Greek alphabet
- a herd of whales
PrepTutorEJDIC
- ガンマ(ギリシア語アルファベットの第3字Γ,γ;英語のG,gに相当)
- (特に女性の)魅力的な脚,すんなりした脚
Wikipedia preview
出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2013/04/04 19:11:39」(JST)
[Wiki en表示]
| cystathionine gamma-lyase |
|
| Cysteine metabolism. Cystathionase catalyzes the lower reaction. |
| Identifiers |
| EC number |
4.4.1.1 |
| CAS number |
9012-96-8 |
| Databases |
| IntEnz |
IntEnz view |
| BRENDA |
BRENDA entry |
| ExPASy |
NiceZyme view |
| KEGG |
KEGG entry |
| MetaCyc |
metabolic pathway |
| PRIAM |
profile |
| PDB structures |
RCSB PDB PDBe PDBsum |
| Gene Ontology |
AmiGO / EGO |
| Search |
| PMC |
articles |
| PubMed |
articles |
| NCBI |
proteins |
|
Cystathionine gamma-lyase (or cystathionase) is an enzyme which breaks down cystathionine into cysteine and α-ketobutyrate. Pyridoxal phosphate is a prosthetic group of this enzyme.
Cystathionine gamma-lyase also catalyses the following elimination reactions:
- L-homoserine to form H2O, NH3 and 2-oxobutanoate
- L-cystine, producing thiocysteine, pyruvate and NH3
- L-cysteine producing pyruvate, NH3 and H2S
In some bacteria and mammals, including humans, this enzyme takes part in generating hydrogen sulfide.[1]
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Contents
- 1 Examples
- 2 Pathology
- 3 See also
- 4 External links
- 5 References
|
Examples
The following cystathionine gamma-lyase is expressed in humans:
| cystathionase (cystathionine gamma-lyase) |
| Identifiers |
| Symbol |
CTH |
| Entrez |
1491 |
| HUGO |
2501 |
| OMIM |
607657 |
| RefSeq |
NM_001902 |
| UniProt |
P32929 |
| Other data |
| EC number |
4.4.1.1 |
| Locus |
Chr. 1 p31.1 |
|
Pathology
An deficiency is associated with cystathioninuria.
See also
External links
- Cystathionine gamma-lyase at the US National Library of Medicine Medical Subject Headings (MeSH)
References
- ^ Wang R (March 2010). "Toxic Gas, Lifesaver". Scientific American: 52.
|
Carbon-sulfur lyases (EC 4.4)
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|
| 4.4.1 |
- Cystathionine gamma-lyase
- Cystathionine beta-lyase
- Leukotriene C4 synthase
|
|
- B
- enzm
- 1.1
- 2
- 3
- 4
- 5
- 6
- 7
- 8
- 10
- 11
- 13
- 14
- 15-18
- 2.1
- 2.7.10
- 2.7.11-12
- 3.1
- 4.1
- 5.1
- 6.1-3
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Metabolism: amino acid metabolism · synthesis and catabolism enzymes (essential in CAPS)
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|
| K→acetyl-CoA |
|
LYSINE→
|
- Saccharopine dehydrogenase
- Glutaryl-CoA dehydrogenase
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|
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LEUCINE→
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- Branched chain aminotransferase
- Branched-chain alpha-keto acid dehydrogenase complex
- Isovaleryl coenzyme A dehydrogenase
- Methylcrotonyl-CoA carboxylase
- Methylglutaconyl-CoA hydratase
- 3-hydroxy-3-methylglutaryl-CoA lyase
|
|
|
TRYPTOPHAN→
|
- Indoleamine 2,3-dioxygenase/Tryptophan 2,3-dioxygenase
- Arylformamidase
- Kynureninase
- 3-hydroxyanthranilate oxidase
- Aminocarboxymuconate-semialdehyde decarboxylase
- Aminomuconate-semialdehyde dehydrogenase
|
|
|
PHENYLALANINE→tyrosine→
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(see below)
|
|
|
| G |
|
G→pyruvate
→citrate
|
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glycine→serine→
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- Serine hydroxymethyltransferase
- Serine dehydratase
- glycine→creatine: Guanidinoacetate N-methyltransferase
- Creatine kinase
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|
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alanine→
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cysteine→
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|
|
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threonine→
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- L-threonine dehydrogenase
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|
|
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G→glutamate→
α-ketoglutarate
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HISTIDINE→
|
- Histidine ammonia-lyase
- Urocanate hydratase
- Formiminotransferase cyclodeaminase
|
|
|
proline→
|
- Proline oxidase
- Pyrroline-5-carboxylate reductase
- 1-Pyrroline-5-carboxylate dehydrogenase/ALDH4A1
- PYCR1
|
|
|
arginine→
|
- Ornithine aminotransferase
- Ornithine decarboxylase
- Agmatinase
|
|
|
→alpha-ketoglutarate→TCA
|
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|
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Other
|
- cysteine+glutamate→glutathione: Gamma-glutamylcysteine synthetase
- Glutathione synthetase
- Gamma-glutamyl transpeptidase
- glutamate→glutamine: Glutamine synthetase
- Glutaminase
|
|
|
|
G→propionyl-CoA→
succinyl-CoA
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VALINE→
|
- Branched chain aminotransferase
- Branched-chain alpha-keto acid dehydrogenase complex
- Enoyl-CoA hydratase
- 3-hydroxyisobutyryl-CoA hydrolase
- 3-hydroxyisobutyrate dehydrogenase
- Methylmalonate semialdehyde dehydrogenase
|
|
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ISOLEUCINE→
|
- Branched chain aminotransferase
- Branched-chain alpha-keto acid dehydrogenase complex
- 3-hydroxy-2-methylbutyryl-CoA dehydrogenase
|
|
|
METHIONINE→
|
- generation of homocysteine: Methionine adenosyltransferase
- Adenosylhomocysteinase
- regeneration of methionine: Methionine synthase/Homocysteine methyltransferase
- Betaine-homocysteine methyltransferase
- conversion to cysteine: Cystathionine beta synthase
- Cystathionine gamma-lyase
|
|
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THREONINE→
|
|
|
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→succinyl-CoA→TCA
|
- Propionyl-CoA carboxylase
- Methylmalonyl CoA epimerase
- Methylmalonyl-CoA mutase
|
|
|
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G→fumarate
|
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PHENYLALANINE→tyrosine→
|
- Phenylalanine hydroxylase
- Tyrosine aminotransferase
- 4-Hydroxyphenylpyruvate dioxygenase
- Homogentisate 1,2-dioxygenase
- Fumarylacetoacetate hydrolase
- tyrosine→melanin: Tyrosinase
|
|
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G→oxaloacetate
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asparagine→aspartate→
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- Asparaginase/Asparagine synthetase
- Aspartate transaminase
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|
|
|
|
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mt, k, c/g/r/p/y/i, f/h/s/l/o/e, a/u, n, m
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k, cgrp/y/i, f/h/s/l/o/e, au, n, m, epon
|
m (A16/C10), i (k, c/g/r/p/y/i, f/h/s/o/e, a/u, n, m)
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UpToDate Contents
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English Journal
- Reduced Cystathionine γ-Lyase and Increased miR-21 Expression Are Associated with Increased Vascular Resistance in Growth-Restricted Pregnancies: Hydrogen Sulfide as a Placental Vasodilator.
- Cindrova-Davies T, Herrera EA, Niu Y, Kingdom J, Giussani DA, Burton GJ.SourceDepartment of Physiology, Development, and Neuroscience and the Centre for Trophoblast Research, University of Cambridge, Cambridge, United Kingdom.
- The American journal of pathology.Am J Pathol.2013 Apr;182(4):1448-58. doi: 10.1016/j.ajpath.2013.01.001. Epub 2013 Feb 12.
- Increased vascular impedance in the fetoplacental circulation is associated with fetal hypoxia and growth restriction. We sought to investigate the role of hydrogen sulfide (H2S) in regulating vasomotor tone in the fetoplacental vasculature. H2S is produced endogenously by catalytic activity of cyst
- PMID 23410520
- The inhibitory role of hydrogen sulfide in airway hyperresponsiveness and inflammation in a mouse model of asthma.
- Zhang G, Wang P, Yang G, Cao Q, Wang R.SourceDepartment of Biology, Lakehead University, Thunder Bay, Ontario, Canada.
- The American journal of pathology.Am J Pathol.2013 Apr;182(4):1188-95. doi: 10.1016/j.ajpath.2012.12.008. Epub 2013 Feb 8.
- Cystathionine γ-lyase (CSE) is one of the major enzymes producing hydrogen sulfide (H2S) in lungs, participating in the regulation of respiratory functions. The role of CSE-derived H2S in eosinophil-dominant inflammation in allergic diseases has been unclear. The objective of this study was to expl
- PMID 23395089
- In African American type 2 diabetic patients, is vitamin D deficiency associated with lower blood levels of hydrogen sulfide and cyclic adenosine monophosphate, and elevated oxidative stress?
- Jain SK, Manna P, Micinski D, Lieblong BJ, Kahlon G, Morehead L, Hoeldtke R, Bass PF 3rd, Levine SN.SourceDepartment of Pediatrics, Louisiana State University Health Sciences Center, Shreveport, LA 71130, USA. sjain@lsuhsc.edu
- Antioxidants & redox signaling.Antioxid Redox Signal.2013 Apr 1;18(10):1154-8. doi: 10.1089/ars.2012.4843. Epub 2012 Sep 13.
- African Americans (AA) have a higher incidence of cardiovascular disease and vitamin D (VD) deficiency compared with Caucasians. Hydrogen sulfide (H(2)S) is an important signaling molecule. This study examined the hypothesis that blood levels of H(2)S are lower in AA type 2 diabetic patients (T2D).
- PMID 22852873
Japanese Journal
- Gastric acid induces mucosal H₂S release in rats by upregulating mRNA and protein expression of cystathionine gamma lyase
- Distribution of Hepatic Cystathionine .GAMMA.-Lyase Activity in Fish
- Murine cystathionine gamma-lyase : complete cDNA and genomic sequences, promoter activity, tissue distribution and developmental expression
Related Links
- Cystathionase uses pyridoxal phosphate to facilitate the cleavage of the sulfur-gamma carbon bond of cystathionine, resulting in the release of cysteine. [3] Afterwards the external ketimine is hydrolyzed, causing the release of α ...
- Catalyzes the last step in the trans-sulfuration pathway from methionine to cysteine. Has broad substrate specificity. Converts cystathionine to cysteine, ammonia and 2-oxobutanoate. Converts two cysteine molecules to lanthionine ...
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γ ガンマ