cyclofenil

シクロフェニル

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出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2014/08/18 15:56:26」(JST)

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Not to be confused with Cycloguanil.

Cyclofenil

Systematic (IUPAC) name
[4-[(4-acetoxyphenyl)-cyclohexylidene-methyl]phenyl] acetate
Clinical data
AHFS/Drugs.com	International Drug Names
Legal status	?
Routes	Oral
Identifiers
CAS number	2624-43-3
ATC code	G03GB01
PubChem	CID 2898
ChemSpider	2795
UNII	J468V64WZ1 Y
KEGG	D01281
ChEMBL	CHEMBL141305
Synonyms	bis(p-acetoxyphenyl)cyclohexylidenemethane
Chemical data
Formula	C23H24O4
Mol. mass	364.434 g/mol
SMILES O=C(Oc3ccc(C(/c1ccc(OC(=O)C)cc1)=C2\CCCCC2)cc3)C

Cyclofenil (INN, trade names Ondogyne, Sexovid, and others) is a selective estrogen receptor modulator.

It was investigated as a possible treatment for scleroderma in the 1980s, but was found to be ineffective. Later study of its efficacy in treating Raynaud's phenomenon in people with scleroderma also found no statistically significant benefit.

References

English Journal

• Meta-analysis of healing and prevention of digital ulcers in systemic sclerosis.

• Tingey T, Shu J, Smuczek J, Pope J.SourceMcMaster University, Hamilton, Ontario, Canada.
• Arthritis care & research.Arthritis Care Res (Hoboken).2013 Sep;65(9):1460-71. doi: 10.1002/acr.22018.
• OBJECTIVE: To assess the efficacy of therapies in healing and preventing digital ulcers (DUs) in systemic sclerosis (SSc; scleroderma).METHODS: Medline and EMBASE databases, and American College of Rheumatology and European League Against Rheumatism abstracts, were searched. Randomized controlled tr
• PMID 23554239

• Cyclofenil as a possible cause of non-arteritic anterior ischaemic optic neuropathy.

• Clarke B, Sykakis E, Parmar DN.SourceDepartment of Ophthalmology, Whipps Cross University Hospital, London, UK. esykakis@gmail.com
• BMJ case reports.BMJ Case Rep.2012 Dec 20;2012. pii: bcr2012007825. doi: 10.1136/bcr-2012-007825.
• A 27-year-old woman receiving the steroid drug cyclofenil as a fertility adjunct, experienced blurred vision 24 h after missing a dose and taking a double dose to 'catch up' with her therapeutic protocol. She was found to have a non-arteritic anterior ischaemic optic neuropathy with a visual hemifie
• PMID 23264159

• Treatments for suppression of lactation.

• Oladapo OT, Fawole B.SourceMaternal and Fetal Health Research Unit, Department of Obstetrics and Gynaecology, Obafemi Awolowo College of Health Sciences, Olabisi Onabanjo University, Sagamu, Ogun State, Nigeria. tixon_y2k@hotmail.com.
• The Cochrane database of systematic reviews.Cochrane Database Syst Rev.2012 Sep 12;9:CD005937. doi: 10.1002/14651858.CD005937.pub3.
• BACKGROUND: Various pharmacologic and non-pharmacologic interventions have been used to suppress lactation after childbirth and relieve associated symptoms. Despite the large volume of literature on the subject, there is currently no universal guideline on the most appropriate approach for suppressi
• PMID 22972088

Japanese Journal

• シクロフェニル周期におけるARTの臨床的検討

• Journal of mammalian ova research = 日本哺乳動物卵子学会誌 20(2), S50, 2003-08-01
• NAID 10011252440

• 子宮内膜脱落膜化モデルを用いた，ｃｌｏｍｉｆｅｎｅ　ｃｉｔｒａｔｅおよびｃｙｃｌｏｆｅｎｉｌの脱落膜化に及ぼす影響の評価

• 産婦人科の進歩 53(3), 232-234, 2001
• NAID 130001223828

• 排卵障害のない不妊症患者に対する排卵誘発の有効性

• 産婦人科の進歩 52(1), 1-5, 2000
• NAID 130004188267

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