crystallisation

結晶化

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crystallization、crystallize

WordNet

1. cause to form crystals or assume crystalline form; "crystallize minerals" (同)crystallise, crystalize, crystalise
2. cause to take on a definite and clear shape; "He tried to crystallize his thoughts" (同)crystallise, crystalise, crystalize
3. assume crystalline form; become crystallized (同)crystalize, crystalise, effloresce
4. the formation of crystals (同)crystallisation, crystallizing
5. a mental synthesis that becomes fixed or concrete by a process resembling crystal formation

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1. 結晶作用;〈C〉結晶体

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出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2017/06/19 11:40:17」(JST)

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"Crystallizing" and "Crystallized" redirect here. For the song, see Crystalised. For other uses, see Crystallization (disambiguation).

Crystallization
Concepts
Crystallization · Crystal growth Recrystallization · Seed crystal Protocrystalline · Single crystal
Methods and technology
Boules Bridgman–Stockbarger technique Czochralski process Fractional crystallization Fractional freezing Hydrothermal synthesis Laser-heated pedestal growth Crystal bar process
Fundamentals
Nucleation · Crystal Crystal structure · Solid

Crystallization is the (natural or artificial) process by which a solid forms, where the atoms or molecules are highly organized into a structure known as a crystal. Some of the ways by which crystals form are through precipitating from a solution, melting, or more rarely deposition directly from a gas. Attributes of the resulting crystal depend largely on factors such as temperature, air pressure, and in the case of liquid crystals, time of fluid evaporation.

Crystallization occurs in two major steps. The first is nucleation, the appearance of a crystalline phase from either a supercooled liquid or a supersaturated solvent. The second step is known as crystal growth, which is the increase in the size of particles and leads to a crystal state. An important feature of this step is the fact that loose particles form layers at the crystal's surface lodge themselves into open inconsistencies such as pores, cracks, etc.

The majority of minerals and organic molecules cristallize easliy, and the resulting crystals are generally of good quality, ie. without visible defects. However, larger biochemical particles, like proteins, are often difficult to crystallize. The ease with which molecules will crystallize strongly depends on the intensity of either atomic forces (in the case of mineral substances), intermolecular forces (organic and biochemical substances) or intramolecular forces (biochemical substances).

Crystallization is also a chemical solid–liquid separation technique, in which mass transfer of a solute from the liquid solution to a pure solid crystalline phase occurs. In chemical engineering, crystallization occurs in a crystallizer. Crystallization is therefore related to precipitation, although the result is not amorphous or disordered, but a crystal.

Process

See also: Crystallization § Dynamics

Play media

Time-lapse of growth of a citric acid crystal. The video covers an area of 2.0 by 1.5 mm and was captured over 7.2 min.

The crystallization process consists of two major events, nucleation and crystal growth which are driven by thermodynamic properties as well as chemical properties. In crystallization Nucleation is the step where the solute molecules or atoms dispersed in the solvent start to gather into clusters, on the microscopic scale (elevating solute concentration in a small region), that become stable under the current operating conditions. These stable clusters constitute the nuclei. Therefore, the clusters need to reach a critical size in order to become stable nuclei. Such critical size is dictated by many different factors (temperature, supersaturation, etc.). It is at the stage of nucleation that the atoms or molecules arrange in a defined and periodic manner that defines the crystal structure — note that "crystal structure" is a special term that refers to the relative arrangement of the atoms or molecules, not the macroscopic properties of the crystal (size and shape), although those are a result of the internal crystal structure.

The crystal growth is the subsequent size increase of the nuclei that succeed in achieving the critical cluster size. Crystal growth is a dynamic process occurring in equilibrium where solute molecules or atoms precipitate out of solution, and dissolve back into solution. Supersaturation is one of the driving forces of crystallization, as the solubility of a species is an equilibrium process quantified by Ksp. Depending upon the conditions, either nucleation or growth may be predominant over the other, dictating crystal size.

Many compounds have the ability to crystallize with some having different crystal structures, a phenomenon called polymorphism. Each polymorph is in fact a different thermodynamic solid state and crystal polymorphs of the same compound exhibit different physical properties, such as dissolution rate, shape (angles between facets and facet growth rates), melting point, etc. For this reason, polymorphism is of major importance in industrial manufacture of crystalline products. Additionally, crystal phases can sometimes be interconverted by varying factors such as temperature.

In nature

Snowflakes are a very well-known example, where subtle differences in crystal growth conditions result in different geometries.

Crystallized honey

There are many examples of natural process that involve crystallization.

Geological time scale process examples include:

• Natural (mineral) crystal formation (see also gemstone);
• Stalactite/stalagmite, rings formation.

Usual time scale process examples include:

• Snow flakes formation;
• Honey crystallization (nearly all types of honey crystallize).

Methods

Crystal formation can be divided into two types, where the first type of crystals are composed of a cation and anion, also known as a salt, such as sodium acetate. The second type of crystals are composed of uncharged species, for example menthol.

Crystal formation can be achieved by various methods, such as: cooling, evaporation, addition of a second solvent to reduce the solubility of the solute (technique known as antisolvent or drown-out), solvent layering, sublimation, changing the cation or anion, as well as other methods.

The formation of a supersaturated solution does not guarantee crystal formation, and often a seed crystal or scratching the glass is required to form nucleation sites.

A typical laboratory technique for crystal formation is to dissolve the solid in a solution in which it is partially soluble, usually at high temperatures to obtain supersaturation. The hot mixture is then filtered to remove any insoluble impurities. The filtrate is allowed to slowly cool. Crystals that form are then filtered and washed with a solvent in which they are not soluble, but is miscible with the mother liquor. The process is then repeated to increase the purity in a technique known as recrystallization.

Typical equipment

Equipment for the main industrial processes for crystallization.

1. Tank crystallizers. Tank crystallization is an old method still used in some specialized cases. Saturated solutions, in tank crystallization, are allowed to cool in open tanks. After a period of time the mother liquor is drained and the crystals removed. Nucleation and size of crystals are difficult to control. Typically, labor costs are very high.

Thermodynamic view

Low-temperature SEM magnification series for a snow crystal. The crystals are captured, stored, and sputter coated with platinum at cryo-temperatures for imaging.

The nature of a crystallization process is governed by both thermodynamic and kinetic factors, which can make it highly variable and difficult to control. Factors such as impurity level, mixing regime, vessel design, and cooling profile can have a major impact on the size, number, and shape of crystals produced.

Now put yourself in the place of a molecule within a pure and perfect crystal, being heated by an external source. At some sharply defined temperature, the complicated architecture of the crystal collapses to that of a liquid. Textbook thermodynamics says that melting occurs because the entropy, S, gain in your system by spatial randomization of the molecules has overcome the enthalpy, H, loss due to breaking the crystal packing forces:

$T(S_{liquid}-S_{solid})>H_{liquid}-H_{solid}$

$G_{liquid}<G_{solid}$

This rule suffers no exceptions when the temperature is rising. By the same token, on cooling the melt, at the very same temperature the bell should ring again, and molecules should click back into the very same crystalline form. The entropy decrease due to the ordering of molecules within the system is overcompensated by the thermal randomization of the surroundings, due to the release of the heat of fusion; the entropy of the universe increases.

But liquids that behave in this way on cooling are the exception rather than the rule; in spite of the second principle of thermodynamics, crystallization usually occurs at lower temperatures (supercooling). This can only mean that a crystal is more easily destroyed than it is formed. Similarly, it is usually much easier to dissolve a perfect crystal in a solvent than to grow again a good crystal from the resulting solution. The nucleation and growth of a crystal are under kinetic, rather than thermodynamic, control.

Dynamics

As mentioned above, a crystal is formed following a well-defined pattern, or structure, dictated by forces acting at the molecular level. As a consequence, during its formation process the crystal is in an environment where the solute concentration reaches a certain critical value, before changing status. Solid formation, impossible below the solubility threshold at the given temperature and pressure conditions, may then take place at a concentration higher than the theoretical solubility level. The difference between the actual value of the solute concentration at the crystallization limit and the theoretical (static) solubility threshold is called supersaturation and is a fundamental factor in crystallization.

Nucleation

Main article: Nucleation

Nucleation is the initiation of a phase change in a small region, such as the formation of a solid crystal from a liquid solution. It is a consequence of rapid local fluctuations on a molecular scale in a homogeneous phase that is in a state of metastable equilibrium. Total nucleation is the sum effect of two categories of nucleation – primary and secondary.

Primary nucleation

Primary nucleation is the initial formation of a crystal where there are no other crystals present or where, if there are crystals present in the system, they do not have any influence on the process. This can occur in two conditions. The first is homogeneous nucleation, which is nucleation that is not influenced in any way by solids. These solids include the walls of the crystallizer vessel and particles of any foreign substance. The second category, then, is heterogeneous nucleation. This occurs when solid particles of foreign substances cause an increase in the rate of nucleation that would otherwise not be seen without the existence of these foreign particles. Homogeneous nucleation rarely occurs in practice due to the high energy necessary to begin nucleation without a solid surface to catalyse the nucleation.

Primary nucleation (both homogeneous and heterogeneous) has been modelled with the following:

$B={\dfrac {dN}{dt}}=k_{n}(c-c^{*})^{n}$

• B is the number of nuclei formed per unit volume per unit time.
• N is the number of nuclei per unit volume.
• k_n is a rate constant.
• c is the instantaneous solute concentration.
• c^* is the solute concentration at saturation.
• (c–c^*) is also known as supersaturation.
• n is an empirical exponent that can be as large as 10, but generally ranges between 3 and 4.

Secondary nucleation

Secondary nucleation is the formation of nuclei attributable to the influence of the existing microscopic crystals in the magma. Simply put, secondary nucleation is when crystal growth is initiated with contact of other existing crystals or "seeds." The first type of known secondary crystallization is attributable to fluid shear, the other due to collisions between already existing crystals with either a solid surface of the crystallizer or with other crystals themselves. Fluid shear nucleation occurs when liquid travels across a Crystal at a high speed, sweeping away nuclei that would otherwise be incorporated into a Crystal, causing the swept-away nuclei to become new crystals. Contact nucleation has been found to be the most effective and common method for nucleation. The benefits include the following:

• Low kinetic order and rate-proportional to supersaturation, allowing easy control without unstable operation.
• Occurs at low supersaturation, where growth rate is optimum for good quality.
• Low necessary energy at which crystals strike avoids the breaking of existing crystals into new crystals.
• The quantitative fundamentals have already been isolated and are being incorporated into practice.

The following model, although somewhat simplified, is often used to model secondary nucleation:

$B={\dfrac {dN}{dt}}=k_{1}M_{T}^{j}(c-c^{*})^{b}$

• k₁ is a rate constant.
• M_T is the suspension density.
• j is an empirical exponent that can range up to 1.5, but is generally 1.
• b is an empirical exponent that can range up to 5, but is generally 2.
  Crystal growth

Growth

Main article: Crystal growth

Once the first small crystal, the nucleus, forms it acts as a convergence point (if unstable due to supersaturation) for molecules of solute touching – or adjacent to – the crystal so that it increases its own dimension in successive layers. The pattern of growth resembles the rings of an onion, as shown in the picture, where each colour indicates the same mass of solute; this mass creates increasingly thin layers due to the increasing surface area of the growing crystal. The supersaturated solute mass the original nucleus may capture in a time unit is called the growth rate expressed in kg/(m²*h), and is a constant specific to the process. Growth rate is influenced by several physical factors, such as surface tension of solution, pressure, temperature, relative crystal velocity in the solution, Reynolds number, and so forth.

The main values to control are therefore:

• Supersaturation value, as an index of the quantity of solute available for the growth of the crystal;
• Total crystal surface in unit fluid mass, as an index of the capability of the solute to fix onto the crystal;
• Retention time, as an index of the probability of a molecule of solute to come into contact with an existing crystal;
• Flow pattern, again as an index of the probability of a molecule of solute to come into contact with an existing crystal (higher in laminar flow, lower in turbulent flow, but the reverse applies to the probability of contact).

The first value is a consequence of the physical characteristics of the solution, while the others define a difference between a well- and poorly designed crystallizer.

Size distribution

The appearance and size range of a crystalline product is extremely important in crystallization. If further processing of the crystals is desired, large crystals with uniform size are important for washing, filtering, transportation, and storage. The importance lies in the fact that large crystals are easier to filter out of a solution than small crystals. Also, larger crystals have a smaller surface area to volume ratio, leading to a higher purity. This higher purity is due to less retention of mother liquor which contains impurities, and a smaller loss of yield when the crystals are washed to remove the mother liquor. The theoretical crystal size distribution can be estimated as a function of operating conditions with a fairly complicated mathematical process called population balance theory (using population balance equations).

Main crystallization processes

Some of the important factors influencing solubility are:

• Concentration
• Temperature
• Polarity
• Ionic Strength

So we may identify two main families of crystallization processes:

• Cooling crystallization
• Evaporative crystallization

This division is not really clear-cut, since hybrid systems exist, where cooling is performed through evaporation, thus obtaining at the same time a concentration of the solution.

A crystallization process often referred to in chemical engineering is the fractional crystallization. This is not a different process, rather a special application of one (or both) of the above.

Cooling crystallization

Application

Most chemical compounds, dissolved in most solvents, show the so-called direct solubility that is, the solubility threshold increases with temperature.

Solubility of the system Na₂SO₄ – H₂O

So, whenever the conditions are favourable, crystal formation results from simply cooling the solution. Here cooling is a relative term: austenite crystals in a steel form well above 1000 °C. An example of this crystallization process is the production of Glauber's salt, a crystalline form of sodium sulfate. In the diagram, where equilibrium temperature is on the x-axis and equilibrium concentration (as mass percent of solute in saturated solution) in y-axis, it is clear that sulfate solubility quickly decreases below 32.5 °C. Assuming a saturated solution at 30 °C, by cooling it to 0 °C (note that this is possible thanks to the freezing-point depression), the precipitation of a mass of sulfate occurs corresponding to the change in solubility from 29% (equilibrium value at 30 °C) to approximately 4.5% (at 0 °C) – actually a larger crystal mass is precipitated, since sulfate entrains hydration water, and this has the side effect of increasing the final concentration.

There are of course limitation in the use of cooling crystallization:

• Many solutes precipitate in hydrate form at low temperatures: in the previous example this is acceptable, and even useful, but it may be detrimental when, for example, the mass of water of hydration to reach a stable hydrate crystallization form is more than the available water: a single block of hydrate solute will be formed – this occurs in the case of calcium chloride);
• Maximum supersaturation will take place in the coldest points. These may be the heat exchanger tubes which are sensitive to scaling, and heat exchange may be greatly reduced or discontinued;
• A decrease in temperature usually implies an increase of the viscosity of a solution. Too high a viscosity may give hydraulic problems, and the laminar flow thus created may affect the crystallization dynamics.
• It is of course not applicable to compounds having reverse solubility, a term to indicate that solubility increases with temperature decrease (an example occurs with sodium sulfate where solubility is reversed above 32.5 °C).

Cooling crystallizers

Vertical cooling crystallizer in a beet sugar factory

The simplest cooling crystallizers are tanks provided with a mixer for internal circulation, where temperature decrease is obtained by heat exchange with an intermediate fluid circulating in a jacket. These simple machines are used in batch processes, as in processing of pharmaceuticals and are prone to scaling. Batch processes normally provide a relatively variable quality of product along the batch.

The Swenson-Walker crystallizer is a model, specifically conceived by Swenson Co. around 1920, having a semicylindric horizontal hollow trough in which a hollow screw conveyor or some hollow discs, in which a refrigerating fluid is circulated, plunge during rotation on a longitudinal axis. The refrigerating fluid is sometimes also circulated in a jacket around the trough. Crystals precipitate on the cold surfaces of the screw/discs, from which they are removed by scrapers and settle on the bottom of the trough. The screw, if provided, pushes the slurry towards a discharge port.

A common practice is to cool the solutions by flash evaporation: when a liquid at a given T₀ temperature is transferred in a chamber at a pressure P₁ such that the liquid saturation temperature T₁ at P₁ is lower than T₀, the liquid will release heat according to the temperature difference and a quantity of solvent, whose total latent heat of vaporization equals the difference in enthalpy. In simple words, the liquid is cooled by evaporating a part of it.

In the sugar industry, vertical cooling crystallizers are used to exhaust the molasses in the last crystallization stage downstream of vacuum pans, prior to centrifugation. The massecuite enters the crystallizers at the top, and cooling water is pumped through pipes in counterflow.

Evaporative crystallization

Another option is to obtain, at an approximately constant temperature, the precipitation of the crystals by increasing the solute concentration above the solubility threshold. To obtain this, the solute/solvent mass ratio is increased using the technique of evaporation. This process is of course insensitive to change in temperature (as long as hydration state remains unchanged).

All considerations on control of crystallization parameters are the same as for the cooling models.

Evaporative crystallizers

Most industrial crystallizers are of the evaporative type, such as the very large sodium chloride and sucrose units, whose production accounts for more than 50% of the total world production of crystals. The most common type is the forced circulation (FC) model (see evaporator). A pumping device (a pump or an axial flow mixer) keeps the crystal slurry in homogeneous suspension throughout the tank, including the exchange surfaces; by controlling pump flow, control of the contact time of the crystal mass with the supersaturated solution is achieved, together with reasonable velocities at the exchange surfaces. The Oslo, mentioned above, is a refining of the evaporative forced circulation crystallizer, now equipped with a large crystals settling zone to increase the retention time (usually low in the FC) and to roughly separate heavy slurry zones from clear liquid. Evaporative crystallizers tend to yield larger average crystal size and narrows the crystal size distribution curve.

DTB crystallizer

DTB Crystallizer

Schematic of DTB

Whichever the form of the crystallizer, to achieve an effective process control it is important to control the retention time and the crystal mass, to obtain the optimum conditions in terms of crystal specific surface and the fastest possible growth. This is achieved by a separation – to put it simply – of the crystals from the liquid mass, in order to manage the two flows in a different way. The practical way is to perform a gravity settling to be able to extract (and possibly recycle separately) the (almost) clear liquid, while managing the mass flow around the crystallizer to obtain a precise slurry density elsewhere. A typical example is the DTB (Draft Tube and Baffle) crystallizer, an idea of Richard Chisum Bennett (a Swenson engineer and later President of Swenson) at the end of the 1950s. The DTB crystallizer (see images) has an internal circulator, typically an axial flow mixer – yellow – pushing upwards in a draft tube while outside the crystallizer there is a settling area in an annulus; in it the exhaust solution moves upwards at a very low velocity, so that large crystals settle – and return to the main circulation – while only the fines, below a given grain size are extracted and eventually destroyed by increasing or decreasing temperature, thus creating additional supersaturation. A quasi-perfect control of all parameters is achieved as DTF crystallizers offer superior control over crystal size and characteristics. This crystallizer, and the derivative models (Krystal, CSC, etc.) could be the ultimate solution if not for a major limitation in the evaporative capacity, due to the limited diameter of the vapour head and the relatively low external circulation not allowing large amounts of energy to be supplied to the system.

See also

• Abnormal grain growth
• Chiral resolution by crystallization
• Crystal habit
• Crystal structure
• Crystallite
• Fractional crystallization (chemistry)
• Igneous differentiation
• Laser heated pedestal growth
• Micro-pulling-down
• Protein crystallization
• Pumpable ice technology
• Quasicrystal
• Recrystallization (chemistry)
• Recrystallization (metallurgy)
• Seed crystal
• Single crystal
• Symplectite
• Vitrification
• X-Ray Crystallography

Further reading

• A. Mersmann, Crystallization Technology Handbook (2001) CRC; 2nd ed. ISBN 0-8247-0528-9
• Tine Arkenbout-de Vroome, Melt Crystallization Technology (1995) CRC ISBN 1-56676-181-6
• "Small Molecule Crystallization" (PDF) at Illinois Institute of Technology website
• Glynn P.D. and Reardon E.J. (1990) "Solid-solution aqueous-solution equilibria: thermodynamic theory and representation". Amer. J. Sci. 290, 164–201.
• Geankoplis, C.J. (2003) "Transport Processes and Separation Process Principles". 4th Ed. Prentice-Hall Inc.
• S.J. Jancic, P.A.M. Grootscholten: “Industrial Crystallization”, Textbook, Delft University Press and Reidel Publishing Company, Delft, The Netherlands, 1984.

External links

• Batch Crystallization
• Industrial Crystallization

English Journal

• Impact of triacylglycerol composition on shear-induced textural changes in highly saturated fats.

• Gregersen SB1, Andersen MD2, Hammershøj M1, Wiking L3.
• Food chemistry.Food Chem.2017 Jan 15;215:438-46. doi: 10.1016/j.foodchem.2016.08.008. Epub 2016 Aug 4.
• This study demonstrates a strong interaction between triacylglycerol (TAG) composition and effects of shear rate on the microstructure and texture of fats. Cocoa butter alternatives with similar saturated fat content, but different major TAGs (PPO-, PSO-, SSO-, POP- and SOS-rich blends) were evaluat
• PMID 27542496

• Crystallisation of minerals from concentrated saline dairy effluent.

• Kezia K1, Lee J2, Zisu B3, Weeks M4, Chen G1, Gras S5, Kentish S6.
• Water research.Water Res.2016 Sep 15;101:300-8. doi: 10.1016/j.watres.2016.05.074. Epub 2016 May 26.
• An understanding of crystallisation within saline effluents is important for the design of both brine crystallisers and brine disposal ponds. In this work, crystallisation of a saline effluent concentrate from the Australian dairy industry has been examined at 22 wt% and 30 wt% total solids and at
• PMID 27267478
• PMID 27221792

Japanese Journal

• Effect of soda-lime-silica glass addition on the physical properties of ceramic obtained from white rice husk ash

• , ,
• Journal of the Ceramic Society of Japan 122(1422), 161-165, 2014
• … The crystallisation behaviour of samples was investigated by XRD analysis after different heat treatments. …
• NAID 130004950929

• Sulphide Capacity and Mineralogy of BaO and B2O3 Modified CaO–Al2O3 Top Slag

• , , , ,
• ISIJ International 54(7), 1570-1577, 2014
• … The crystallisation path of the slag during cooling was predicted based on a Scheil-Gulliver model. …
• NAID 130004678446

• Effects of Valence Control of Iron Ions on Radiative Heat Transfer in Mould Flux

• , , ,
• ISIJ International 53(10), 1725-1731, 2013
• … Some glassy samples were heat-treated for crystallisation. …
• NAID 130003383794

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「crystallization」

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crystal growth、crystallisation、crystallize

　 　 　

「crystallize」

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• 結晶化する、晶出させる

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crystallisation、crystallization

　 　 　

「結晶化」

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crystallization、crystallisation、crystallize

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