WordNet

the direction of an orchestra or choir; "he does not use a baton for conducting"
the way of administering a business
a trodden path (同)footpath

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Early life stress elicits visceral hyperalgesia and functional reorganization of pain circuits in adult rats.

Holschneider DP1, Guo Y2, Mayer EA3, Wang Z4.
Neurobiology of stress.Neurobiol Stress.2016 Jun 1;3:8-22.
Early life stress (ELS) is a risk factor for developing functional gastrointestinal disorders, and has been proposed to be related to a central amplification of sensory input and resultant visceral hyperalgesia. We sought to characterize ELS-related changes in functional brain responses during acute
PMID 26751119

A porohyperelastic finite element model of the eye: the influence of stiffness and permeability on intraocular pressure and optic nerve head biomechanics.

Ayyalasomayajula A1, Park RI2, Simon BR1,3, Vande Geest JP1,4,5.
Computer methods in biomechanics and biomedical engineering.Comput Methods Biomech Biomed Engin.2016 May;19(6):591-602. doi: 10.1080/10255842.2015.1052417. Epub 2015 Jul 21.
Progressively deteriorating visual field is a characteristic feature of primary open-angle glaucoma (POAG), and the biomechanics of optic nerve head (ONH) is believed to be important in its onset. We used porohyperelasticity to model the complex porous behavior of ocular tissues to better understand
PMID 26195024

Downregulation of tumor suppressing STF cDNA 3 promotes epithelial-mesenchymal transition and tumor metastasis of osteosarcoma by the Wnt/GSK-3β/β-catenin/Snail signaling pathway.

Lv YF1, Dai H2, Yan GN1, Meng G3, Zhang X3, Guo QN4.
Cancer letters.Cancer Lett.2016 Apr 10;373(2):164-73. doi: 10.1016/j.canlet.2016.01.046. Epub 2016 Feb 1.
Epithelial to mesenchymal transition (EMT) has received considerable attention as a conceptual paradigm for explaining the invasive and metastatic behavior of cells during cancer progression. Our previous study showed that loss of expression of TSSC3 is positively associated with osteosarcoma malign
PMID 26845447

Discovery of a Novel Nicotinamide Phosphoribosyl Transferase (NAMPT) Inhibitor via in Silico Screening

Takeuchi Mikio,Niimi Tatsuya,Masumoto Mari [他],Orita Masaya,Yokota Hiroyuki,Yamamoto Tomoko
Biological and Pharmaceutical Bulletin 37(1), 31-36, 2014
… Nicotinamide phosphoribosyl transferase (NAMPT) is a key enzyme in the salvage pathway of mammalian nicotinamide adenine dinucleotide (NAD) biosynthesis, catalyzing the synthesis of nicotinamide mononucleotide from nicotinamide (Nam). … However, difficulty in conducting high-throughput NAMPT assay with good sensitivity has hampered the discovery of novel anti-NAMPT drugs with improved profiles. …
NAID 130003382094

1) 多嚢胞性卵巣症候群病態解明に向けた総合戦略(シンポジウム3:生殖「多嚢胞性卵巣症候群(PCOS)の病因・病態と管理」,第65回日本産科婦人科学会・学術講演会)

岩瀬明
日本産科婦人科學會雜誌 65(12), 2683-2697, 2013-12-01
… The biological functions of growth factors on granulosa cell proliferation are mainly mediated by the PI3K-Akt pathway and MEK-ERK 1/2 pathway. … Therefore, conducting analyses of follicular fluid might be helpful in identifying molecules related with the pathogenesis of PCOS. … GnRH neurons are the final common pathway to regulate the hypothalamus-pituitary-gonad axis. …
NAID 110009685694

Cooperative Functions of ZnT1, Metallothionein and ZnT4 in the Cytoplasm Are Required for Full Activation of TNAP in the Early Secretory Pathway

Fujimoto Shigeyuki,Itsumura Naoya,Tsuji Tokuji,Anan Yasumi,Tsuji Natsuko,Ogra Yasumitsu,Kimura Tomoki,Miyamae Yusaku,Masuda Seiji,Nagao Masaya,Kambe Taiho
PLoS ONE 8(10), 2013-10-18
… We have previously shown that secretory and membrane-bound zinc enzymes are activated in the early secretory pathway (ESP) via zinc-loading by the zinc transporter 5 (ZnT5)-ZnT6 hetero-complex and ZnT7 homo-complex (zinc transport complexes). … However, how other proteins conducting zinc metabolism affect the activation of these enzymes remains unknown. … In ZnT1^[−/−]MT^[−/−]ZnT4^[−/−] cells, the secretory pathway normally operates. …
NAID 120005343924