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English Journal

Folic Acid Supplementation in Postpolypectomy Patients in a Randomized Controlled Trial Increases Tissue Folate Concentrations and Reduces Aberrant DNA Biomarkers in Colonic Tissues Adjacent to the Former Polyp Site.

O'Reilly SL1, McGlynn AP2, McNulty H2, Reynolds J3, Wasson GR2, Molloy AM4, Strain JJ2, Weir DG4, Ward M2, McKerr G2, Scott JM1, Downes CS5.
The Journal of nutrition.J Nutr.2016 May;146(5):933-9. doi: 10.3945/jn.115.222547. Epub 2016 Apr 13.
BACKGROUND: Low folate status is associated with an increased risk of colorectal carcinogenesis. Optimal folate status may be genoprotective by preventing uracil misincorporation into DNA and DNA hypomethylation. Adenomatous polyps have low folate status compared with normal colonic mucosa, and they
PMID 27075913

Detrimental effects for colonocytes of an increased exposure to luminal hydrogen sulfide: The adaptive response.

Beaumont M1, Andriamihaja M1, Lan A1, Khodorova N1, Audebert M2, Blouin JM1, Grauso M1, Lancha L3, Benetti PH1, Benamouzig R4, Tomé D1, Bouillaud F5, Davila AM1, Blachier F6.
Free radical biology & medicine.Free Radic Biol Med.2016 Apr;93:155-64. doi: 10.1016/j.freeradbiomed.2016.01.028. Epub 2016 Feb 2.
Protein fermentation by the gut microbiota releases in the large intestine lumen various amino-acid derived metabolites. Among them, hydrogen sulfide (H2S) in excess has been suspected to be detrimental for colonic epithelium energy metabolism and DNA integrity. The first objective of this study was
PMID 26849947

NEMO Prevents RIP Kinase 1-Mediated Epithelial Cell Death and Chronic Intestinal Inflammation by NF-κB-Dependent and -Independent Functions.

Vlantis K1, Wullaert A1, Polykratis A1, Kondylis V1, Dannappel M1, Schwarzer R1, Welz P1, Corona T1, Walczak H2, Weih F3, Klein U4, Kelliher M5, Pasparakis M6.
Immunity.Immunity.2016 Mar 15;44(3):553-67. doi: 10.1016/j.immuni.2016.02.020.
Intestinal epithelial cells (IECs) regulate gut immune homeostasis, and impaired epithelial responses are implicated in the pathogenesis of inflammatory bowel diseases (IBD). IEC-specific ablation of nuclear factor κB (NF-κB) essential modulator (NEMO) caused Paneth cell apoptosis and impaired ant
PMID 26982364