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出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2015/09/20 01:13:12」(JST)

Cloperastine is a cough suppressant that acts on the central nervous system.^[1]

References

^ De Blasio, F.; Dicpinigaitis, P. V.; Rubin, B. K.; De Danieli, G.; Lanata, L.; Zanasi, A. (2012). "An observational study on cough in children: Epidemiology, impact on quality of sleep and treatment outcome". Cough 8 (1): 1. doi:10.1186/1745-9974-8-1. PMC 3274450. PMID 22269875.

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Cloperastine rescues impairment of passive avoidance response in mice prenatally exposed to diethylstilbestrol.

Soeda F1, Hirakawa E, Inoue M, Shirasaki T, Takahama K.
Environmental toxicology.Environ Toxicol.2014 Feb;29(2):216-25. doi: 10.1002/tox.21749. Epub 2012 Jan 5.
We previously reported that prenatal exposure to diethylstilbestrol (DES) impaired passive avoidance responses in mice. Apart from the above, we also found that cloperastine, a centrally acting antitussive, ameliorated depression-like and anxiety-like behaviors in rodents at antitussive-effective do
PMID 22223406

Gregori-Puigjané E1, Setola V, Hert J, Crews BA, Irwin JJ, Lounkine E, Marnett L, Roth BL, Shoichet BK.
Proceedings of the National Academy of Sciences of the United States of America.Proc Natl Acad Sci U S A.2012 Jul 10;109(28):11178-83. doi: 10.1073/pnas.1204524109. Epub 2012 Jun 18.
Notwithstanding their key roles in therapy and as biological probes, 7% of approved drugs are purported to have no known primary target, and up to 18% lack a well-defined mechanism of action. Using a chemoinformatics approach, we sought to "de-orphanize" drugs that lack primary targets. Surprisingly
PMID 22711801

Development of chromatographic methods for the determination of genotoxic impurities in cloperastine fendizoate.

García A1, Rupérez FJ, Ceppa F, Pellati F, Barbas C.
Journal of pharmaceutical and biomedical analysis.J Pharm Biomed Anal.2012 Mar 5;61:230-6. doi: 10.1016/j.jpba.2011.12.014. Epub 2011 Dec 19.
The classification of an impurity of a drug substance as genotoxic means that the "threshold of toxicological concern" (TTC) value of 1.5 μg/day intake, considered to be associated with an acceptable risk, should be the admissible limit in the raw material and that leads to new analytical challenge
PMID 22226040

Effects of the Antitussive Drug Cloperastine on Ventricular Repolarization in Halothane-Anesthetized Guinea Pigs

Takahara Akira,Fujiwara Kaori,Ohtsuki Atsushi [他],OKA Takayuki,NAMEKATA Iyuki,TANAKA Hikaru
Journal of pharmacological sciences 120(3), 165-175, 2012-11-20
… Cloperastine is an antitussive drug, which can be received as an over-the-counter cold medicine. … The chemical structure of cloperastine is quite similar to that of the antihistamine drug diphenhydramine, which is reported to inhibit hERG K+ … To analyze its proarrhythmic potential, we compared effects of cloperastine and diphenhydramine on the hERG K+ … Cloperastine inhibited the hERG K+ …
NAID 10031147563

山本巌,副田二三夫,白哲哉 [他],高濱和夫
薬学雑誌. 乙号 131(4), 523-532, 2011
… We previously reported that dextromethorphan (DM) and cloperastine (CP), centrally acting antitussives, reduce the frequency of micturition reflex and increase the threshold pressure in anesthetized rats. …
NAID 130000678832

川浦一晃,本田宗吉,副田二三夫 [他],白哲哉,高濱和夫
薬学雑誌. 乙号 130(5), 699-705, 2010
… Tipepidine, cloperastine and caramiphen significantly reduced the immobility in forced swimming test (FST) using normal rats. …
NAID 130000259458

Cloperastine
Systematic (IUPAC) name
	1-[2-[(4-chlorophenyl)-phenyl-methoxy]ethyl]piperidine
Clinical data
AHFS/Drugs.com	International Drug Names
Identifiers
CAS Registry Number	3703-76-2
ATC code	R05DB21
PubChem	CID: 2805
DrugBank	DB09002
ChemSpider	2703
UNII	69M5L7BXEK
KEGG	D03557
ChEMBL	CHEMBL415087
Chemical data
Formula	C20H24ClNO
Molecular mass	329.863 g/mol
	SMILES Clc1ccc(cc1)C(OCCN2CCCCC2)c3ccccc3 ;
	InChI InChI=1S/C20H24ClNO/c21-19-11-9-18(10-12-19)20(17-7-3-1-4-8-17)23-16-15-22-13-5-2-6-14-22/h1,3-4,7-12,20H,2,5-6,13-16H2 ; Key:FLNXBVJLPJNOSI-UHFFFAOYSA-N ;
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