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出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2013/01/28 18:11:26」(JST)

Clinofibrate (INN, trade name Lipoclin) is a fibrate.

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English Journal

Effect of food on the single-dose pharmacokinetics and tolerability of clinofibrate tablets in Chinese healthy volunteers.

Li JK1, Ding LK, Li XQ, Chen MC, Wang L, Yang J, Song Y, Song W, Jia YY, Wen AD.
International journal of clinical pharmacology and therapeutics.Int J Clin Pharmacol Ther.2013 Aug;51(8):672-7.
The aim of this study is to investigate a food effect on the single-dose pharmacokinetics and tolerability of clinofibrate tablets in 12 Chinese healthy volunteers. The authors evaluated the effect of being under a fasting or fed state at the time of drug intake on the single-dose of clinofibrate 40
PMID 23849436

High-performance liquid chromatographic method for determination of clinofibrate and its application to a pharmacokinetic study in healthy volunteers.

Jian-Kang L1, Ying S, Lei W, Minchun C, Wei S, Xueqing L, Xiao-Li S, Guangqing L, Yan-Yan J, Ai-Dong W.
Journal of pharmaceutical and biomedical analysis.J Pharm Biomed Anal.2013 Mar 25;76:152-6. doi: 10.1016/j.jpba.2012.12.008. Epub 2012 Dec 20.
A convenient and rapid HPLC method was developed for the determination of clinofibrate in human plasma using simple protein precipitation with the mixture of acetonitrile and 1M hydrochloric acid (95:5, v/v) followed by separation using an Inspire C(18) column with isocratic elution. The detection w
PMID 23319135

In vitro evaluation of inhibitory effects of antidiabetic and antihyperlipidemic drugs on human carboxylesterase activities.

Fukami T1, Takahashi S, Nakagawa N, Maruichi T, Nakajima M, Yokoi T.
Drug metabolism and disposition: the biological fate of chemicals.Drug Metab Dispos.2010 Dec;38(12):2173-8. doi: 10.1124/dmd.110.034454. Epub 2010 Sep 1.
Human carboxylesterase (CES) 1A is responsible for the biotransformation of angiotensin-converting enzyme (ACE) inhibitors such as imidapril and temocapril. Because antidiabetic or antihyperlipidemic drugs are often coadministered with ACE inhibitors in clinical pharmacotherapy, the inhibitory effec
PMID 20810539

A case of familial hypercholesterolemia; secession from LDL-apheresis by the drug treatment with potent statin and resin

SHIINA Yutaka,HOMMA Yasuhiko,OGUMA Toshiaki,FUSEGAWA Yuichi,OZAWA Hideki,HANDA Shunnosuke,TANABE Teruhisa
Tokai journal of experimental and clinical medicine 30(3), 149-155, 2005-09
… LDL-cholesterol (C) level was not successfully controlled despite the administration of a statin, pravastatin, a fibrate, clinofibrate and probucol at maximum doses Concomitantly. …
NAID 110005052006

Clinical efficacy of Clinofibrate in combination with pravastatin in patients with hyperlipidemia The Journal of medicine

リンク元	「クリノフィブラート」「クリノフィブレート」

Clinofibrate
Systematic (IUPAC) name
	2-(4-{1-[4-(1-carboxy-1-methylpropoxy)phenyl]cyclohexyl}phenoxy)-2-methylbutanoic acid
Clinical data
AHFS/Drugs.com	International Drug Names
Pregnancy cat.	?
Legal status	℞ Prescription only
Routes	Oral
Identifiers
CAS number	30299-08-2
ATC code	None
PubChem	CID 2787
ChemSpider	21613360
UNII	0374EZJ8CU
KEGG	D01300
Chemical data
Formula	C28H36O6
Mol. mass	468.58 g/mol
	SMILES CCC(C)(C(=O)O)OC1=CC=C(C=C1)C2(CCCCC2)C3=CC=C(C=C3)OC(C)(CC)C(=O)O;
	InChI InChI=1S/C28H36O6/c1-5-26(3,24(29)30)33-22-15-13-20(14-16-22)28(17-8-7-9-18-28)21-11-10-12-23(19-21)34-27(4,6-2)25(31)32/h10-16,19H,5-9,17-18H2,1-4H3,(H,29,30)(H,31,32) ; Key:OGGAHXJZRRGBTK-UHFFFAOYSA-N ;
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