WordNet

being long-lasting and recurrent or characterized by long suffering; "chronic indigestion"; "a chronic shortage of funds"; "a chronic invalid"
of long duration; "chronic money problems" (同)continuing
habitual; "a chronic smoker" (同)inveterate
a pathological condition resulting from an excessive intake of fluorine (usually from drinking water)

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1. 食物中の微量ミネラルの概要 overview of dietary trace minerals
2. 骨軟化症の疫学および病因 epidemiology and etiology of osteomalacia
3. 成人における低カルシウム血症の原因 etiology of hypocalcemia in adults
4. 乳幼児に対する予防的デンタルケアおよびカウンセリング preventive dental care and counseling for infants and young children
5. 歯の発達障害 developmental defects of the teeth

Analysis of Naturally Occurring Fluoride in Commercial Teas and Estimation of Its Daily Intake through Tea Consumption.

Peng CY, Cai HM, Zhu XH1, Li DX1, Yang YQ1, Hou RY1, Wan XC1.
Journal of food science.J Food Sci.2015 Dec 8. doi: 10.1111/1750-3841.13180. [Epub ahead of print]
The aim of this study was to determine the levels of fluoride in commercial teas and to estimate the contribution of tea consumption to the fluoride recommended daily allowance. A total of 558 tea products in 6 categories, green tea, black tea, oolong tea, pu'er tea, white tea, and reprocessed tea,
PMID 26647101

Fluoride induces oxidative damage and SIRT1/autophagy through ROS-mediated JNK signaling.

Suzuki M1, Bandoski C1, Bartlett JD2.
Free radical biology & medicine.Free Radic Biol Med.2015 Dec;89:369-78. doi: 10.1016/j.freeradbiomed.2015.08.015. Epub 2015 Sep 30.
Fluoride is an effective caries prophylactic, but at high doses can also be an environmental health hazard. Acute or chronic exposure to high fluoride doses can result in dental enamel and skeletal and soft tissue fluorosis. Dental fluorosis is manifested as mottled, discolored, porous enamel that i
PMID 26431905

Impact of early developmental fluoride exposure on the peripheral pain sensitivity in mice.

Ma J1, Liu F2, Liu P3, Dong YY4, Chu Z3, Hou TZ5, Dang YH6.
International journal of developmental neuroscience : the official journal of the International Society for Developmental Neuroscience.Int J Dev Neurosci.2015 Dec;47(Pt B):165-71. doi: 10.1016/j.ijdevneu.2015.09.005. Epub 2015 Sep 30.
Consumption of high concentration of fluoride in the drinking water would cause the fluorosis and chronic pain. Similar pain syndrome appeared in the patients in fluoride therapy of osteoporotic. The aim of the current study was to examine whether exposing immature mice to fluoride would modify the
PMID 26431775

藤江奏,高橋宏通,岩田久敬
日本畜産学会報 31(1), 1960
… Relations between the fluorine contents of the animal body, drinking water, and feedstuffs, and chronic fluorine poisoning were studied by determining the fluorine contents in them.2. …
NAID 130000739984