慢性移植腎症
WordNet
- being long-lasting and recurrent or characterized by long suffering; "chronic indigestion"; "a chronic shortage of funds"; "a chronic invalid"
- of long duration; "chronic money problems" (同)continuing
- habitual; "a chronic smoker" (同)inveterate
PrepTutorEJDIC
- (病気が)長期にわたる,慢性の / 《名詞の前にのみ用いて》常習の,癖になった
Wikipedia preview
出典(authority):フリー百科事典『ウィキペディア(Wikipedia)』「2017/10/03 23:59:45」(JST)
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Chronic allograft nephropathy |
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Micrograph of chronic allograft nephropathy. PAS stain. |
Classification and external resources |
Specialty |
urology |
[edit on Wikidata]
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Chronic allograft nephropathy, abbreviated CAN and also known as sclerosing/chronic allograft nephropathy, is the leading cause of kidney transplant failure[1] and happens month to years after the transplant.
Contents
- 1 Symptoms
- 2 Diagnosis
- 3 Pathology
- 4 References
Symptoms
CAN is characterized by a gradual decline in kidney function and, typically, accompanied by high blood pressure and hematuria.[2]
Diagnosis
CAN is diagnosed by examination of tissue, e.g. a kidney biopsy.
Pathology
The histopathology is characterized by interstitial fibrosis, tubular atrophy, fibrotic intimal thickening of arteries and glomerulosclerosis.[2][3]
References
- ^ Paul, LC. (Sep 1999). "Chronic allograft nephropathy: An update.". Kidney Int. 56 (3): 783–93. PMID 10469349. doi:10.1046/j.1523-1755.1999.00611.x.
- ^ a b Joosten, SA.; Sijpkens, YW.; van Kooten, C.; Paul, LC. (Jul 2005). "Chronic renal allograft rejection: pathophysiologic considerations.". Kidney Int. 68 (1): 1–13. PMID 15954891. doi:10.1111/j.1523-1755.2005.00376.x.
- ^ Nankivell, BJ.; Chapman, JR. (Mar 2006). "Chronic allograft nephropathy: current concepts and future directions.". Transplantation. 81 (5): 643–54. PMID 16534463. doi:10.1097/01.tp.0000190423.82154.01.
UpToDate Contents
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English Journal
- Early subclinical rejection treated with low dose i.v. steroids is not associated to graft survival impairment: 13-years' experience at a single center.
- Gigliotti P1, Lofaro D, Leone F, Papalia T, Senatore M, Greco R, Perri A, Vizza D, Lupinacci S, Toteda G, La Russa A, De Stefano R, Romeo F, Bonofiglio R.
- Journal of nephrology.J Nephrol.2015 May 13. [Epub ahead of print]
- Subclinical rejection (SCR) has been variably associated with reduced graft survival, development and progression of interstitial fibrosis/tubular atrophy and chronic allograft nephropathy, but data are controversial concerning SCR treatment in terms of graft survival improvement. In this single-cen
- PMID 25966801
- Different Risk Factor Profiles Distinguish Early-onset from Late-onset BKV-Replication.
- Schachtner T1,2, Babel N1,2, Reinke P1,2.
- Transplant international : official journal of the European Society for Organ Transplantation.Transpl Int.2015 May 9. doi: 10.1111/tri.12601. [Epub ahead of print]
- BACKGROUND: Two of three reactivations of latent BKV-infection occur within in the first 6 months after renal transplantation. However, a clear differentiation between early-onset and late-onset BKV-replication is lacking.METHODS: Here, we studied all kidney transplant recipients (KTRs) at our singl
- PMID 25959355
- Urinary biomarkers of chronic allograft nephropathy.
- Cassidy H1, Slyne J1, O'Kelly P2, Traynor C3, Conlon PJ2, Johnston O4, Slattery C1, Ryan MP1, McMorrow T1.
- Proteomics. Clinical applications.Proteomics Clin Appl.2015 May 8. doi: 10.1002/prca.201400200. [Epub ahead of print]
- PURPOSE: Chronic Allograft Nephropathy (CAN) is widely accepted as the leading cause of renal allograft loss after the first year post transplantation. This study aimed to identify urinary biomarkers which could predict CAN in transplant patients.METHOD: The study included 34 renal transplant patien
- PMID 25951805
Japanese Journal
- Reduced-dose Cyclosporine with Mycophenolate Mofetil and Prednisone Significantly Improves the Long-term Glomerular Filtration Rate and Graft Survival
- Wang Rending,Xu Ying,Wu Jianyong,Wang Yimin,He Qiang,Chen Jianghua
- Internal Medicine 52(9), 947-953, 2013
- … Objective It remains debated whether reduced doses of chronic calcineurin inhibitors benefit graft survival. … The Modification of Diet in Renal Disease (MDRD) glomerular filtration rate (GFR) calculated at different time points, graft survival, the incidence of chronic allograft nephropathy (CAN) and the acute rejection rate within six months were analyzed and compared between the two groups. …
- NAID 130003366012
- Long-term graft outcome in patients with chronic allograft nephropathy after immunosuppression modifications
- EL-AGROUDY Amgad E.,EL-DAHSHAN Khaled F.,MAHMOUD Khaled,ISMAIL Amani M.,EL-BAZ Mahmoud,SHOKEIR Ahmed A.,GHONEIM Mohamed A.
- Clinical and experimental nephrology 13(1), 66-72, 2009-02-01
- NAID 10025585808
- Association of cytokine polymorphisms with subclinical progressive chronic allograft nephropathy in Japanese renal transplant recipients : Preliminary study
- SATOH Shigeru,SAITO Mitsuru,INOUE Kazuyuki,MIURA Masatomo,KOMATSUDA Atsushi,HABUCHI Tomonori
- International journal of urology 14(11), 990-994, 2007-11-01
- NAID 10019799301
Related Links
- Perspectives in Renal Medicine Kidney International (1999) 56, 783–793; doi:10.1046/j.1523-1755.1999.00611.x Chronic allograft nephropathy: An update ... Department of Nephrology, Leiden University Medical Center, Leiden, The ...
- Chronic allograft nephropathy (CAN) is the leading cause of renal allograft loss in paediatric renal transplant recipients. CAN is the result of immunological and nonimmunological injury, including acute rejection episodes ...
★リンクテーブル★
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- 英
- chronic allograft nephropathy
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- 関
- chronically、chronicity