10番染色体、第10染色体、第10番染色体

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a threadlike strand of DNA in the cell nucleus that carries the genes in a linear order; "humans have 22 chromosome pairs plus two sex chromosomes"

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染色体

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出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2015/07/01 18:06:03」(JST)

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Chromosome 10 is one of the 23 pairs of chromosomes in humans. People normally have two copies of this chromosome. Chromosome 10 spans about 135 million base pairs (the building material of DNA) and represents between 4 and 4.5 percent of the total DNA in cells.

Identifying genes on each chromosome is an active area of genetic research. Because researchers use different approaches to predict the number of genes on each chromosome, the estimated number of genes varies. Chromosome 10 likely contains between 800 and 1,200 genes.^[2]

Genes

The following are some of the genes located on chromosome 10:

ALOX5: Arachidonate 5-Lipoxygenase (processes essential fatty acids to leukotrienes, which are important agents in the inflammatory response; also facilitates development and maintenance of cancer stem cells, slow-dividing cells thought to give rise to a variety of cancers, including leukemia);
CAMK1D: calcium/calmodulin-dependent protein kinase ID
CDH23: cadherin-like 23
CXCL12: chemokine (C-X-C motif) ligand 12, SDF-1, scyb12
EGR2: early growth response 2 (Krox-20 homolog, Drosophila)
ERCC6: excision repair cross-complementing rodent repair deficiency, complementation group 6
FGFR2: fibroblast growth factor receptor 2 (bacteria-expressed kinase, keratinocyte growth factor receptor, craniofacial dysostosis 1, Crouzon syndrome, Pfeiffer syndrome, Jackson-Weiss syndrome)
HELLS: Lymphoid-specific helicase
PCBD1: 6-pyruvoyl-tetrahydropterin synthase/dimerization cofactor of hepatocyte nuclear factor 1 alpha (TCF1)
PCDH15: protocadherin 15
PTEN gene: phosphatase and tensin homolog (mutated in multiple advanced cancers 1)
RET: ret proto-oncogene (multiple endocrine neoplasia and medullary thyroid carcinoma 1, Hirschsprung disease)
UROS: uroporphyrinogen III synthase (congenital erythropoietic porphyria)
PROSER2: proline and serine rich 2 or c10orf47

Diseases & disorders

The following diseases are related to genes on chromosome 10:

Apert syndrome
Beare-Stevenson cutis gyrata syndrome
Charcot-Marie-Tooth disease
Charcot-Marie-Tooth disease, type 1
Charcot-Marie-Tooth disease, type 4
Cockayne syndrome
congenital erythropoietic porphyria
Cowden syndrome
Crouzon syndrome
Glioblastoma Multiforme
Hermansky-Pudlak syndrome
Hirschprung disease
Jackson-Weiss syndrome
multiple endocrine neoplasia type 2
nonsyndromic deafness
nonsyndromic deafness, autosomal recessive
Pfeiffer syndrome
porphyria
tetrahydrobiopterin deficiency
Thiel-Behnke corneal dystrophy
Usher syndrome
Usher syndrome type I
Wolman syndrome

References

^ "Table 2.3: Human chromosome groups". Human Molecular Genetics (2nd ed.). Garland Science. 1999.
^ Chromosome 10 - Genetics Home Reference

Deloukas P, Earthrowl ME, Grafham DV, Rubenfield M, French L, Steward CA, Sims SK, Jones MC, Searle S, Scott C, Howe K, Hunt SE, Andrews TD, Gilbert JG, Swarbreck D, Ashurst JL, Taylor A, Battles J, Bird CP, Ainscough R, Almeida JP, Ashwell RI, Ambrose KD, Babbage AK, Bagguley CL, Bailey J, Banerjee R, Bates K, Beasley H, Bray-Allen S, Brown AJ, Brown JY, Burford DC, Burrill W, Burton J, Cahill P, Camire D, Carter NP, Chapman JC, Clark SY, Clarke G, Clee CM, Clegg S, Corby N, Coulson A, Dhami P, Dutta I, Dunn M, Faulkner L, Frankish A, Frankland JA, Garner P, Garnett J, Gribble S, Griffiths C, Grocock R, Gustafson E, Hammond S, Harley JL, Hart E, Heath PD, Ho TP, Hopkins B, Horne J, Howden PJ, Huckle E, Hynds C, Johnson C, Johnson D, Kana A, Kay M, Kimberley AM, Kershaw JK, Kokkinaki M, Laird GK, Lawlor S, Lee HM, Leongamornlert DA, Laird G, Lloyd C, Lloyd DM, Loveland J, Lovell J, McLaren S, McLay KE, McMurray A, Mashreghi-Mohammadi M, Matthews L, Milne S, Nickerson T, Nguyen M, Overton-Larty E, Palmer SA, Pearce AV, Peck AI, Pelan S, Phillimore B, Porter K, Rice CM, Rogosin A, Ross MT, Sarafidou T, Sehra HK, Shownkeen R, Skuce CD, Smith M, Standring L, Sycamore N, Tester J, Thorpe A, Torcasso W, Tracey A, Tromans A, Tsolas J, Wall M, Walsh J, Wang H, Weinstock K, West AP, Willey DL, Whitehead SL, Wilming L, Wray PW, Young L, Chen Y, Lovering RC, Moschonas NK, Siebert R, Fechtel K, Bentley D, Durbin R, Hubbard T, Doucette-Stamm L, Beck S, Smith DR, Rogers J (2004). "The DNA sequence and comparative analysis of human chromosome 10". Nature 429 (6990): 375–81. doi:10.1038/nature02462. PMID 15164054.
Deloukas P, French L, Meitinger T, Moschonas NK (2000). "Report of the third international workshop on human chromosome 10 mapping and sequencing 1999". Cytogenet Cell Genet 90 (1–2): 1–12. doi:10.1159/000015653. PMID 11060438.
Gilbert F (2001). "Chromosome 10". Genet Test 5 (1): 69–82. doi:10.1089/109065701750168824. PMID 11336406.

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UpToDate Contents

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1. 先天性の細胞遺伝学的異常 congenital cytogenetic abnormalities
2. 骨髄異形成症候群における細胞遺伝学および分子遺伝学 cytogenetics and molecular genetics of myelodysplastic syndromes
3. 性染色体異常 sex chromosome abnormalities
4. Peeling skin syndrome
5. 慢性骨髄性白血病の分子遺伝学 molecular genetics of chronic myeloid leukemia

English Journal

Lymphocyte-mediated macrophage apoptosis during IL-12 stimulation.

Yim JY, Yang SJ, Yim JM, Song MY, Rho HW, Yim SK, Han YH, Jeon SY, Kim HS, Yhim HY, Lee NR, Song EK, Kwak JY, Sohn MH, Yim CY.SourceDepartment of Internal Medicine, Chonbuk National University Medical School, Jeonju, Jeonbuk 561-180, Republic of Korea; Biomedical Research Institute, Chonbuk National University Hospital, Jeonju, Jeonbuk 561-712, Republic of Korea; Advanced Research Center for Cancer, Chonbuk National University Hospital, Jeonju, Jeonbuk 561-712, Republic of Korea.
Cytokine.Cytokine.2013 Oct;64(1):62-70. doi: 10.1016/j.cyto.2013.07.027. Epub 2013 Aug 15.
In contrast to the well known immunostimulatory roles of IL-12, little has been known about its immunosuppressive roles. In the present study, IL-12-activated lymphocyte-mediated macrophage apoptosis was investigated by employing murine lymphocyte/macrophage cocultures. IL-12-activated lymphocytes a
PMID 23953854

Associations of the PTEN -9C>G polymorphism with insulin sensitivity and central obesity in Chinese.

Yang Q, Cao H, Xie S, Tong Y, Zhu Q, Zhang F, Lü Q, Yang Y, Li D, Chen M, Yu C, Jin W, Yuan Y, Tong N.SourceDivision of Endocrinology and Metabolism, West China Hospital of Sichuan University, Chengdu, Sichuan, China.
Gene.Gene.2013 Sep 25;527(2):545-52. doi: 10.1016/j.gene.2013.06.026. Epub 2013 Jun 21.
BACKGROUND: Phosphatase and tensin homolog on chromosome 10 gene (PTEN) is known as a tumor-suppressor gene. Previous studies demonstrated that PTEN dysfunction affects the function of insulin. However, investigations of PTEN single nucleotide polymorphisms (SNPs) and IR-related disease associations
PMID 23796801

Troglitazone upregulates PTEN expression and induces the apoptosis of pulmonary artery smooth muscle cells under hypoxic conditions.

Pi WF, Guo XJ, Su LP, Xu WG.SourceDepartment of Respiratory Medicine, Xinhua Hospital, School of Medicine, Shanghai Jiaotong University, Shanghai, P.R. China.
International journal of molecular medicine.Int J Mol Med.2013 Sep 11. doi: 10.3892/ijmm.2013.1487. [Epub ahead of print]
The increased proliferation and decreased apoptosis of pulmonary artery smooth muscle cells (PASMCs) are the main causes of hypoxic pulmonary hypertension. In this study, we investigated the role of troglitazone [peroxisome proliferator-activated receptor γ (PPARγ) agonist] in the regulation of p
PMID 24026200

Japanese Journal

2)流産における免疫学的機序の解明 : 免疫グロブリン治療は流産抑止に有効か(シンポジウム1「流産の原因と対策」,第63回日本産科婦人科学会・学術講演会)

島田茂樹
日本産科婦人科學會雜誌 63(12), 2153-2166, 2011-12-01
… C: In the decidua, no significant differences in NK cell or NKT cell percentages were found among miscarriage (MS) with normal chromosome karyotype (MSNK), MS with abnormal chromosome karyotype (MSAK) and induced abortion (IA). … The overall live birth rate was 91% among 46 women, excluding 10 MSAK cases. … Administration of high-dose intact human immunoglobulin (IH-Ig) significantly reduced the fetal resorption rate from 55% to 10%. …
NAID 110008799035

DYRK1A binds to an evolutionarily conserved WD40-repeat protein WDR68 and induces its nuclear translocation.

Miyata Yoshihiko,Nishida Eisuke
Biochimica et biophysica acta 1813(10
… DYRK1A is encoded in the Down's syndrome critical region on human chromosome 21, and plays an important role in the functional and developmental regulation of many types of cells, including neuronal cells. …
NAID 80021957231

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リンク元	「10番染色体」「第10染色体」「第10番染色体」

「10番染色体」

Chromosome 10 (human)
Features
Length (bp)	133,797,422 bp
Number of genes	1,607
Type	Autosome
Centromere position	Submetacentric
Identifiers
RefSeq	NC_000010
GenBank	CM000672