関: chondroitinase

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English Journal

Impact of treatment duration and lesion size on effectiveness of chondroitinase treatment post-SCI.

Mondello SE1, Jefferson SC1, Tester NJ1, Howland DR2.
Experimental neurology.Exp Neurol.2015 May;267:64-77. doi: 10.1016/j.expneurol.2015.02.028. Epub 2015 Feb 26.
The effects of 2weeks of intralesional chondroitinase abc (ch'abc) treatment on anatomical plasticity and behavioral recovery are examined in adult cats and compared to results achieved with 4weeks of treatment following tightly controlled lateral hemisection injuries. Analyses also were completed u
PMID 25725355

Perineuronal net digestion with chondroitinase restores memory in mice with tau pathology.

Yang S1, Cacquevel M2, Saksida LM3, Bussey TJ3, Schneider BL2, Aebischer P2, Melani R4, Pizzorusso T5, Fawcett JW1, Spillantini MG6.
Experimental neurology.Exp Neurol.2015 Mar;265:48-58. doi: 10.1016/j.expneurol.2014.11.013. Epub 2014 Dec 4.
Alzheimer's disease is the most prevalent tauopathy and cause of dementia. We investigate the hypothesis that reactivation of plasticity can restore function in the presence of neuronal damage resulting from tauopathy. We investigated two models with tau hyperphosphorylation, aggregation and neurode
PMID 25483398

Role for chondroitin sulfate glycosaminoglycan in NEDD9-mediated breast cancer cell growth.

Iida J1, Dorchak J2, Clancy R2, Slavik J2, Ellsworth R3, Katagiri Y4, Pugacheva EN5, van Kuppevelt TH6, Mural RJ2, Cutler ML7, Shriver CD8.
Experimental cell research.Exp Cell Res.2015 Jan 15;330(2):358-70. doi: 10.1016/j.yexcr.2014.11.002. Epub 2014 Nov 13.
There are lines of evidence demonstrating that NEDD9 (Cas-L, HEF-1) plays a key role in the development, progression, and metastasis of breast cancer cells. We previously reported that NEDD9 plays a critical role for promoting migration and growth of MDA-MB-231. In order to further characterize the
PMID 25445787

Japanese Journal

Sulfation of chondroitin sulfate secreted by baby hamster kidney cells and their polyoma virus-transformed counterparts.

SUGAHARA Kazuyuki,FUKUI Shigeyuki,YAMASHINA Ikuo
The Journal of Biochemistry 98(4), 875-885, 1985
… Sulfation of glycosaminoglycans (GAGs) secreted by baby hamster kidney (BHK) cells and the polyoma virus-transformants (PY-BHK) was investigated. … It has been reported that chondroitin sulfate (CS) of cell membranes from PY-BHK cells is undersulfated compared to that from BHK cells (Cancer Res. … In the first series of experiments of the present study, cells were incubated with [3 H] glucosamine and [35 S] sulfate, and GAGs isolated from the culture medium were examined. …
NAID 130003543458

Multiple forms of chondroitinase AC from Arthrobacter aurescens.

HIYAMA Keiichiro,OKADA Shigetaka
Agricultural and
… While the isolated soil bacterium, Arthrobacter aurescens, had been found to secrete a chondroitinase AC into the culture medium, it was recognized that the chondroitinase preparation obtained from the broth of the strain cultured in a jar fermentor contained at least three electrophoretically separable components of the enzyme. …
NAID 130003525765