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1. 変形性関節症の初回薬物療法 initial pharmacologic therapy of osteoarthritis
2. 尿素サイクル障害：管理 urea cycle disorders management
3. 尿素サイクル障害：臨床的特徴および診断 urea cycle disorders clinical features and diagnosis
4. 初期薬物療法に反応しない変形性関節症の治療 treatment of osteoarthritis resistant to initial pharmacologic therapy
5. 正常な副腎皮質性第二次性徴 normal adrenarche

English Journal

The ovine newborn and human foetal intervertebral disc contain perlecan and aggrecan variably substituted with native 7D4 CS sulphation motif: spatiotemporal immunolocalisation and co-distribution with Notch-1 in the human foetal disc.

Shu C, Hughes C, Smith SM, Smith MM, Hayes A, Caterson B, Little CB, Melrose J.SourceRaymond Purves Bone and Joint Research Laboratories, Kolling Institute of Medical Research, Royal North Shore Hospital and University of Sydney, St. Leonards, NSW, 2065, Australia.
Glycoconjugate journal.Glycoconj J.2013 Oct;30(7):717-25. doi: 10.1007/s10719-013-9475-9. Epub 2013 Jun 13.
Composite agarose (1.2 %) polyacrylamide (0.6 %) gel electrophoresis was used to separate discrete populations of native aggrecan and perlecan in newborn to 10 year old ovine intervertebral discs (IVDs). Semi-dry immunoblotting using core-protein and glycosaminoglycan (GAG) side chain specific mo
PMID 23756834

Chondroitinase from baculovirus Bombyx mori nucleopolyhedrovirus and chondroitin sulfate from silkworm Bombyx mori.

Sugiura N, Ikeda M, Shioiri T, Yoshimura M, Kobayashi M, Watanabe H.SourceInstitute for Molecular Science of Medicine, Aichi Medical University, Nagakute, Aichi 480-1195.
Glycobiology.Glycobiology.2013 Sep 18. [Epub ahead of print]
Chondroitin sulfate is a linear polysaccharide, composed of repeating disaccharide units of glucuronic acid (GlcUA) and N-acetyl-D-galactosamine (GalNAc) with sulfate groups at various positions. Baculovirus is an insect-pathogenic virus that infects Lepidoptera larvae. Recently, we found that the o
PMID 24052236

Surface glycosaminoglycans mediate adherence between HeLa cells and Lactobacillus salivarius Lv72.

Martín R, Martín C, Escobedo S, Suárez JE, Quirós LM.AbstractBACKGROUND: The adhesion of lactobacilli to the vaginal surface is of paramount importance to develop their probiotic functions. For this reason, the role of HeLa cell surface proteoglycans in the attachment of Lactobacillus salivarius Lv72, a mutualistic strain of vaginal origin, was investigated.
BMC microbiology.BMC Microbiol.2013 Sep 17;13(1):210. [Epub ahead of print]
BACKGROUND: The adhesion of lactobacilli to the vaginal surface is of paramount importance to develop their probiotic functions. For this reason, the role of HeLa cell surface proteoglycans in the attachment of Lactobacillus salivarius Lv72, a mutualistic strain of vaginal origin, was investigated.R
PMID 24044741

Identification of human hyaluronidase-4 as a novel chondroitin sulfate hydrolase that preferentially cleaves the galactosaminidic linkage in the trisulfated tetrasaccharide sequence

KANEIWA T.
Glycobiology 20(3), 300-309, 2010-03
… Human hyaluronidases have been considered to be the enzymes acting at the initial step in the catabolism of chondroitin sulfate (CS) in vivo. … We have identified a chondroitin hydrolase in Caenorhabditis elegans, which effectively degrades chondroitin but depolymerizes HA to a much lesser extent (Kaneiwa T, Yamada S, Mizumoto S, Montaño AM, Mitani S, Sugahara K. …
NAID 80020938579

Characterization of Chondroitin/Dermatan Sulfate Proteoglycans Synthesized by Bovine Retinal Pericytes in Culture(Highlighted paper selected by Editor-in-chief)(Biochemistry/Molecular Biology)

Kaji Toshiyuki,Sakurai Shigeru,Yamamoto Chika [他],FUJIWARA Yasuyuki,YAMAGISHI Sho-ichi,YAMAMOTO Hiroshi,KINSELLA Michael G.,WIGHT Thomas N.
Biological & pharmaceutical bulletin 27(11), 1763-1768, 2004-11-01
… Separated proteoglycans were digested with papain, heparitinase or chondroitin ABC lyase and the GAGs characterized by Sepharose CL-6B chromatography. … Proteoglycans were also assessed by sodium dodecyl sulfate polyacrylamide gel electrophoresis before and after digestion with chondroitin ABC lyase. …
NAID 110003608693

REGULATION OF BIGLYCAN AND DECORIN SYNTHESIS BY CONNECTIVE TISSUE GROWTH FACTOR IN CULTURED BOVINE AORTIC ENDOTHELIAL CELLS

Yamamoto Chika,Oh-i Mami,Fujiwara Yasuyuki,Kaji Toshiyuki,Nishida Takashi,Nakanishi Tohru,Takigawa Masaharu,Kinsella Michael G.,Wight Thomas N.
Connective tissue 34(1), 50, 2002-04
… The glycosaminoglycan (GAGs) M_r and composition were analyzed by Sepharose CL-6B chromatography, and the core protein M_r was analyzed by SDS-polyacrylamide gel electrophoresis, before and after digestion with papain, heparitinase or chondroitin ABC lyase. … However, neither the hydrodynamic size nor the GAG chain length of these two small chondroitin/dermatan sulfate proteoglycans was changed by the growth factor. …
NAID 110004002464