chondrocytic

English Journal

Iterative design of peptide-based hydrogels and the effect of network electrostatics on primary chondrocyte behavior.

Sinthuvanich C, Haines-Butterick LA, Nagy KJ, Schneider JP.SourceChemical Biology Laboratory, National Cancer Institute, Frederick National Laboratory for Cancer Research, Frederick, MD 21702, USA; Department of Chemistry and Biochemistry, University of Delaware, Newark, DE 19716, USA.
Biomaterials.Biomaterials.2012 Oct;33(30):7478-88. Epub 2012 Jul 28.
Iterative peptide design was used to generate two peptide-based hydrogels to study the effect of network electrostatics on primary chondrocyte behavior. MAX8 and HLT2 peptides have formal charge states of +7 and +5 per monomer, respectively. These peptides undergo triggered folding and self-assemb
PMID 22841922

Chondroprotective and anti-inflammatory role of melanocortin peptides in TNF-α activated human C-20/A4 chondrocytes.

Kaneva MK, Kerrigan MJ, Grieco P, Curley GP, Locke IC, Getting SJ.SourceSchool of Life Sciences, University of Westminster, London, UK School of Science, University of Greenwich, Chatham, UK Department of Chemistry, University of Naples, Naples, Italy.
British journal of pharmacology.Br J Pharmacol.2012 Sep;167(1):67-79. doi: 10.1111/j.1476-5381.2012.01968.x.
BACKGROUND AND PURPOSE: Melanocortin MC(1) and MC(3 ) receptors, mediate the anti-inflammatory effects of melanocortin peptides. Targeting these receptors could therefore lead to development of novel anti-inflammatory therapeutic agents. We investigated the expression of MC(1) and MC(3) receptors
PMID 22471953

Adenoviral vector expressing IGF-1 protects murine chondrogenic ATDC5 cells against hydrogen peroxide-induced mitochondrial dysfunction and apoptosis