α3β4 nicotinic receptors in the medial habenula and substance P transmission in the interpeduncular nucleus modulate nicotine sensitization.
Eggan BL1, McCallum SE2.
Behavioural brain research.Behav Brain Res.2017 Jan 1;316:94-103. doi: 10.1016/j.bbr.2016.08.028. Epub 2016 Aug 13.
The medial habenula-interpeduncular nucleus (MHb-IPN) pathway has recently been shown to modulate multiple effects nicotine in vivo, however it remains unclear which receptor subtypes in this pathway are critical for mediating these responses. To identify MHb and IPN receptors that play a role in ni
Dopamine (DA) and acetylcholine (ACh) signals converge onto protein kinase A (PKA) in medium spiny neurons of the striatum to control cellular and synaptic activities of these neurons, although underlying molecular mechanisms are less clear. Here we measured phosphorylation of the α-amino-3-hydroxy
Anti-cholinergic and Ca2+-antagonist mechanisms explain the pharmacological basis for folkloric use of Sisymbrium irio Linn. in gastrointestinal, airways and vascular system ailments.
Journal of ethnopharmacology.J Ethnopharmacol.2016 Dec 4;193:474-480. doi: 10.1016/j.jep.2016.09.028. Epub 2016 Sep 30.
ETHNOPHARMACOLOGICAL RELEVANCE: Seeds of Sisymbrium irio Linn has been used traditionally in different regions of Pakistan for the treatment of gastrointestinal, airways and vascular system ailments. To insight the pharmacological basis, in vitro study was conducted in order to validate its folklori
Like the nicotinic cholinoceptor, it is a pentameric structure and modern techniques of genetic engineering (in particular the production of "knock-out" and "knock-in" mice) have been employed to determine the influences of those five ...