関: glycerylphosphorylcholine

WordNet

a B-complex vitamin that is a constituent of lecithin; essential in the metabolism of fat

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出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2012/10/22 14:57:18」(JST)

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L-Alpha Glycerylphosphorylcholine (Alpha GPC, choline alfoscerate) is a natural choline compound found in the brain and in milk. It is also a parasympathomimetic acetylcholine precursor^[1] which may have potential for the treatment of Alzheimer's disease and is used as a nootropic dietary supplement to enhance memory and cognition.

Alpha GPC rapidly delivers choline to the brain across the blood–brain barrier and is a biosynthetic precursor of the acetylcholine neurotransmitter.^[2] Alpha GPC is derived from highly purified soy lecithin by companies like Lipoid, VAV Life Sciences, Chemi SPA etc.

Studies have investigated its efficacy for cognitive disorders including stroke and Alzheimer’s Disease. An Italian multicentre clinical trial on 2,044 patients suffering from recent stroke were supplied alpha-GPC in doses of 1,000 mg/day for 28 days and 400 mg three times per day for the five ensuing months. The trial confirmed the therapeutic role of alpha-GPC on the cognitive recovery of patients based on four measurement scales, three of which reached statistical significance.^[3]

Commonly used doses are 300-1,200 mg daily.^{[citation needed]}

References

^ De Jesus Moreno Moreno M (January 2003). "Cognitive improvement in mild to moderate Alzheimer's dementia after treatment with the acetylcholine precursor choline alfoscerate: a multicenter, double-blind, randomized, placebo-controlled trial". Clin Ther 25 (1): 178–93. doi:10.1016/S0149-2918(03)90023-3. PMID 12637119. http://linkinghub.elsevier.com/retrieve/pii/S0149291803900233.
^ Parnetti, Lucilla; et al. (2007). "Cholinergic precursors in the treatment of cognitive impairment of vascular origin: Ineffective approaches or need for re-evaluation?". Journal of the Neurological Sciences 257 (1–2): 264–9. doi:10.1016/j.jns.2007.01.043. PMID 17331541.
^ Barbagallo Sangiorgi G, et al. "Alpha-Glycerophosphocholine in the mental recovery of cerebral ischemic attacks." An Italian multicenter clinical trial. Ann NY Acad Sci 1994; 717:253-69.

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English Journal

Methane biogenesis during sodium azide-induced chemical hypoxia in rats.

Tuboly E, Szabó A, Garab D, Bartha G, Janovszky A, Eros G, Szabó A, Mohácsi A, Szabó G, Kaszaki J, Ghyczy M, Boros M.SourceInstitute of Surgical Research, Univ. of Szeged, P. O. Box 427, H-6701 Szeged, Hungary. boros.mihaly@med.u-szeged.hu.
American journal of physiology. Cell physiology.Am J Physiol Cell Physiol.2013 Jan;304(2):C207-14. doi: 10.1152/ajpcell.00300.2012. Epub 2012 Nov 21.
Previous studies demonstrated methane generation in aerobic cells. Our aims were to investigate the methanogenic features of sodium azide (NaN(3))-induced chemical hypoxia in the whole animal and to study the effects of l-α-glycerylphosphorylcholine (GPC) on endogenous methane production and inflam
PMID 23174561

Lipid fingerprinting in women with early-onset preeclampsia: a first look.

De Oliveira L, Câmara NO, Bonetti T, Lo Turco EG, Bertolla RP, Moron AF, Sass N, Da Silva ID.SourceObstetrics Department, Universidade Federal de São Paulo, Brazil. Leminas@ig.com.br
Clinical biochemistry.Clin Biochem.2012 Jul;45(10-11):852-5. doi: 10.1016/j.clinbiochem.2012.04.012. Epub 2012 Apr 21.
OBJECTIVES: The aim of this preliminary study was to characterize the plasma lipid profiling of women with preeclampsia.DESIGN AND METHODS: Plasma samples of 8 pregnant women with early-onset preeclampsia and 8 normal pregnant women were evaluated. Lipids were extracted from plasma using the Bligh-D
PMID 22548912

Investigation of microbore UPLC and nontraditional mobile phase compositions for bioanalytical LC-MS/MS.

Rainville PD, Simeone JL, McCarthy SM, Smith NW, Cowan D, Plumb RS.SourceKing's College London, London, UK. paul_rainville@waters.com
Bioanalysis.Bioanalysis.2012 Jun;4(11):1287-97. doi: 10.4155/bio.12.78.
BACKGROUND: The movement towards environmentally friendly or green chemistry solutions has gained more prominence recently in the scientific community. One way in which scientists can address this issue is to limit the use of hazardous chemicals in their everyday processes. Therefore, the focus of t
PMID 22720648

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★リンクテーブル★

リンク元	「コリンアルホスセラート」「glycerylphosphorylcholine」

「コリンアルホスセラート」

Alpha-GPC
Systematic (IUPAC) name
	[(2S)-2,3-dihydroxypropyl] 2-trimethylazaniumylethyl phosphate
Clinical data
Pregnancy cat.	?
Legal status	OTC
Identifiers
CAS number	28319-77-9
ATC code	N07AX02
PubChem	CID 71920
ChemSpider	571409
ChEBI	CHEBI:55397
ChEMBL	CHEMBL1567463
Chemical data
Formula	C8H20NO6P
Mol. mass	257.221 g/mol
	SMILES [O-]P(=O)(OC[C@H](O)CO)OCC[N+](C)(C)C;
	InChI InChI=1S/C8H20NO6P/c1-9(2,3)4-5-14-16(12,13)15-7-8(11)6-10/h8,10-11H,4-7H2,1-3H3/t8-/m1/s1 ; Key:SUHOQUVVVLNYQR-MRVPVSSYSA-N ;
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