English Journal

Sandwich-cultured rat hepatocytes as an in vitro model to study canalicular transport alterations in cholestasis.

Miszczuk GS1, Barosso IR, Zucchetti AE, Boaglio AC, Pellegrino JM, Sánchez Pozzi EJ, Roma MG, Crocenzi FA.
Archives of toxicology.Arch Toxicol.2014 Jun 10. [Epub ahead of print]
At present, it has not been systematically evaluated whether the functional alterations induced by cholestatic compounds in canalicular transporters involved in bile formation can be reproduced in sandwich-cultured rat hepatocytes (SCRHs). Here, we focused on two clinically relevant cholestatic agen
PMID 24912783

Prednisolone increases enterohepatic cycling of bile acids by induction of Asbt and promotes reverse cholesterol transport.

Out C1, Dikkers A2, Laskewitz A2, Boverhof R2, van der Ley C3, Kema IP3, Wolters H2, Havinga R2, Verkade HJ2, Kuipers F4, Tietge UJ2, Groen AK4.
Journal of hepatology.J Hepatol.2014 Mar 26. pii: S0168-8278(14)00206-2. doi: 10.1016/j.jhep.2014.03.025. [Epub ahead of print]
BACKGROUND & AIMS: Glucocorticoids, produced by the adrenal gland under control of the hypothalamic-pituitary-adrenal axis, exert their metabolic actions largely via activation of the glucocorticoid receptor (GR). Synthetic glucocorticoids are widely used as anti-inflammatory and immunosuppressi
PMID 24681341

Endothelin-1 and -3 induce choleresis in the rat through ETB receptors coupled to nitric oxide and vagovagal reflexes.

Rodriguez MR1, Soria LR, Ventimiglia MS, Najenson AC, Di María A, Dabas P, Fellet A, Marinelli RA, Vatta MS, Bianciotti LG.
Clinical science (London, England : 1979).Clin Sci (Lond).2013 Dec;125(11):521-32. doi: 10.1042/CS20120633.
We have reported previously that centrally applied ET (endothelin)-1 and ET-3 induce either choleresis or cholestasis depending on the dose. In the present study, we sought to establish the role of these endothelins in the short-term peripheral regulation of bile secretion in the rat. Intravenously
PMID 23642207

Japanese Journal

Tauroursodeoxycholate-induced choleresis involves p38 (MAPK) activation and translocation of bile salt export pump in rats

KAWAMURA Ikuo,TAKESHITA Shigeru,FUSHIMI Mariko,MABUCHI Miyuki,SEKI Jiro,TOMOI Masaaki,GOTO Toshio
Endocrine journal 47(3), 249-255, 2000-06
NAID 10006176193