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出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2013/10/06 01:43:33」(JST)

Chlorothen is an antihistamine and anticholinergic.^[1]

References[edit]

^ Daniel Bovet (April 1950). "Introduction to antihistamine agents and antergan derivatives". Annals of the New York Academy of Sciences 50: 1089–1126. doi:10.1111/j.1749-6632.1950.tb39905.x.

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Carcinogenicity studies of some analogs of the carcinogen methapyrilene in F344 rats.

Lijinsky W, Kovatch RM.AbstractFour antihistaminic drugs similar in structure to the rat liver carcinogen methapyrilene were administered to comparable groups of male and female F344 rats in their drinking water for most of their lifetime (80-108 weeks). The concentrations were 0.1% or 0.05% and the total doses received by the animals were comparable with that of methapyrilene which induced 100% incidence of liver neoplasms. No increase in incidence of liver neoplasms was observed after treatment with any of the four compounds, thenyldiamine, chlorothen, methafurylene, or methaphenilene, although each differed structurally from methapyrilene only in one atom or one position of substitution. There were a few animals with neoplasms not usually found in untreated F344 rats, but none of these was found in statistically significant numbers. These results suggest that none of the four analogs of methapyrilene was carcinogenic under the conditions of this study, and that the property of inducing liver neoplasms in rats was confined to the intact methapyrilene molecule.
Journal of cancer research and clinical oncology.J Cancer Res Clin Oncol.1986;112(1):57-60.
Four antihistaminic drugs similar in structure to the rat liver carcinogen methapyrilene were administered to comparable groups of male and female F344 rats in their drinking water for most of their lifetime (80-108 weeks). The concentrations were 0.1% or 0.05% and the total doses received by the an
PMID 2874146

Andrews AW, Lijinsky W, Snyder SW.Abstract8 drugs that are amines or amides and that interact with nitrous acid to form potentially carcinogenic and mutagenic N-nitroso derivatives were tested for mutagenicity to Salmonella typhimurium. None of the compounds was mutagenic alone, with or without liver S9 activation. After reaction with nitrite in acetic acid solution, the products of 4 of the compounds were mutagenic. Diphenhydramine and hydrochlorothiazide gave products mutagenic with or without activation, but only to strain TA98. Methaphenilene gave products mutagenic to TA1538, TA98 and TA100 without microsomal activation. Dimethyldodecylamine-N-oxide after nitrosation was mutagenic with S9 activation to TA1535 indicating a response to the nitrosomethyldodecylamine formed. Allantoin, pyrilamine, chlorothen, methafurylene and thenyldiamine were not mutagenic alone or after nitrosation.
Mutation research.Mutat Res.1984 Feb;135(2):105-8.
8 drugs that are amines or amides and that interact with nitrous acid to form potentially carcinogenic and mutagenic N-nitroso derivatives were tested for mutagenicity to Salmonella typhimurium. None of the compounds was mutagenic alone, with or without liver S9 activation. After reaction with nitri
PMID 6363913

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リンク元

Chlorothen
Systematic (IUPAC) name
	N-[(5-chloro-2-thienyl)methyl]-N',N'-dimethyl-N-(2-pyridyl)ethane-1,2-diamine
Clinical data
Pregnancy cat.	?
Legal status	?
Routes	Oral
Identifiers
CAS number	148-65-2
ATC code	?
PubChem	CID 8993
ChemSpider	8645
UNII	Y6068K376I
Chemical data
Formula	C14H18ClN3S
Mol. mass	295.83 g/mol
	SMILES Clc1sc(cc1)CN(c2ncccc2)CCN(C)C;


Systematic (IUPAC) name
N-[(5-chloro-2-thienyl)methyl]-N',N'-dimethyl-N-(2-pyridyl)ethane-1,2-diamine
Clinical data
Pregnancy cat.	?
Legal status	?
Routes	Oral
Identifiers
CAS number	148-65-2
ATC code	?
PubChem	CID 8993
ChemSpider	8645
UNII	Y6068K376I
Chemical data
Formula	C₁₄H₁₈ClN₃S
Mol. mass	295.83 g/mol
SMILES Clc1sc(cc1)CN(c2ncccc2)CCN(C)C